| General information | | DisProt: | DP00299 | | Name: | PemK-like protein 1 | | Synonym(s): | CHPA_ECOLI
Protein mazF
| | First appeared in release: | Release 3.0 (02/17/2006) | | UniProt: | P0AE70 | | UniGene: | | | SwissProt: | CHPA_ECOLI | | TrEMBL: | | | NCBI (GI): | 83286875 | | Source organism: | Escherichia coli | | Sequence length: | 111 | | Percent disordered: | 14% | | Homologues: | |
| Native sequence |
10 20 30 40 50 60
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MVSRYVPDMG DLIWVDFDPT KGSEQAGHRP AVVLSPFMYN NKTGMCLCVP CTTQSKGYPF - 60
EVVLSGQERD GVALADQVKS IAWRARGATK KGTVAPEELQ LIKAKINVLI G
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| Functional narrative |
May be involved in the regulation of cell growth. It acts as a growth inhibitor. Both chpR and chpA bind to the promoter region of the chpRA operon to autoregulate their synthesis.
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| Map of ordered and disordered regions |
Note: 'Mouse' over a region to see the start and stop residues. Click on a region to see detailed information.
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| Region 1 | | Type: | Disordered | | Name: | S1-S2 loop | | Location: | 20 - 26 | | Length: | 7 | | Region sequence: |
TKGSEQA | | Modification type: | Complex
| | PDB: | 1UB4:B | | Structural/functional type: | Function arises from the disordered state
| | Functional classes: | Molecular assembly
| | Functional subclasses: | Apoptosis Regulation
Protein-protein binding
| Detection methods:
- X-ray crystallography (277 K; pH: 4.5; DTT 10 mM; glycerol (v/v) 15 %; NaAcetate 100 mM; NaCl 2 M; protein complex (40 mg/ml))
| References:
- Kamada K, Hanaoka F, Burley SK. "Crystal structure of the MazE/MazF complex: molecular bases of antidote-toxin recognition." Mol Cell. 2003; 11(4): 875-84. PubMed: 12718874
| Comments:Molecule B
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| Region 2 | | Type: | Disordered | | Name: | S1-S2 loop | | Location: | 18 - 27 | | Length: | 10 | | Region sequence: |
DPTKGSEQAG | | Modification type: | Complex
| | PDB: | 1UB4:A | | Structural/functional type: | Function arises from the disordered state
| | Functional classes: | Molecular assembly
| | Functional subclasses: | Apoptosis Regulation
Protein-protein binding
| Detection methods:
- X-ray crystallography (277 K; pH: 4.5; DTT 10 mM; glycerol (v/v) 15 %; NaAcetate 100 mM; NaCl 2 M; protein complex (40 mg/ml))
| References:
- Kamada K, Hanaoka F, Burley SK. "Crystal structure of the MazE/MazF complex: molecular bases of antidote-toxin recognition." Mol Cell. 2003; 11(4): 875-84. PubMed: 12718874
| Comments:Molecule A
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| Region 3 | | Type: | Disordered | | Name: | | | Location: | 67 - 71 | | Length: | 5 | | Region sequence: |
QERDG | | Modification type: | Complex
| | PDB: | | | Structural/functional type: | Relationship to function unknown
| | Functional classes: | Unknown
| | Functional subclasses: | Unknown
| Detection methods:
- X-ray crystallography (277 K; pH: 4.5; DTT 10 mM; glycerol (v/v) 15 %; NaAcetate 100 mM; NaCl 2 M; protein complex (40 mg/ml))
| References:
- Kamada K, Hanaoka F, Burley SK. "Crystal structure of the MazE/MazF complex: molecular bases of antidote-toxin recognition." Mol Cell. 2003; 11(4): 875-84. PubMed: 12718874
| Comments:
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