Annotation for this protein is in progress - please check future releases for more complete information


DP00304: RAC-beta serine/threonine-protein kinaseFASTA viewXML view

General information
DisProt:DP00304
Name:RAC-beta serine/threonine-protein kinase
Synonym(s):AKT2_HUMAN
EC=2.7.11.1
RAC-PK-beta
Protein kinase Akt-2
Protein kinase B, beta
PKB beta
First appeared in release:Release 3.0 (02/17/2006)
UniProt:P31751
UniGene:Hs.631535
SwissProt: AKT2_HUMAN
TrEMBL:  
NCBI (GI): 1170703
Source organism:Homo sapiens (Human)
Sequence length:481
Percent disordered:16%
Homologues: 


Native sequence

        10         20         30         40         50         60
         |          |          |          |          |          |
MNEVSVIKEG WLHKRGEYIK TWRPRYFLLK SDGSFIGYKE RPEAPDQTLP PLNNFSVAEC - 60
QLMKTERPRP NTFVIRCLQW TTVIERTFHV DSPDEREEWM RAIQMVANSL KQRAPGEDPM - 120
DYKCGSPSDS STTEEMEVAV SKARAKVTMN DFDYLKLLGK GTFGKVILVR EKATGRYYAM - 180
KILRKEVIIA KDEVAHTVTE SRVLQNTRHP FLTALKYAFQ THDRLCFVME YANGGELFFH - 240
LSRERVFTEE RARFYGAEIV SALEYLHSRD VVYRDIKLEN LMLDKDGHIK ITDFGLCKEG - 300
ISDGATMKTF CGTPEYLAPE VLEDNDYGRA VDWWGLGVVM YEMMCGRLPF YNQDHERLFE - 360
LILMEEIRFP RTLSPEAKSL LAGLLKKDPK QRLGGGPSDA KEVMEHRFFL SINWQDVVQK - 420
KLLPPFKPQV TSEVDTRYFD DEFTAQSITI TPPDRYDSLG LLELDQRTHF PQFSYSASIR - 480
E



Functional narrative    

General protein kinase capable of phosphorylating several known proteins.

Region 9: 143-145 Region 5: 143-146 Region 1: 189-197 Region 10: 190-201 Region 6: 189-202 Region 11: 298-310 Region 2: 297-312 Region 7: 295-313 Region 3: 442-460 Region 4: 443-480 Region 8: 441-481

Map of ordered and disordered regions







Note: 'Mouse' over a region to see the start and stop residues. Click on a region to see detailed information.


Region 1
Type:Disordered
Name: 
Location:189 - 197
Length:9
Region sequence:

IAKDEVAHT

Modification type:  
PDB: 1GZK:A, 1GZN:A
Structural/functional type:  
Functional classes:  
Functional subclasses:  
Detection methods:
 
References:
  1. Yang J, Cron P, Thompson V, Good VM, Hess D, Hemmings BA, Barford D. "Molecular mechanism for the regulation of protein kinase B/Akt by hydrophobic motif phosphorylation." Mol Cell. 2002; 9(6): 1227-40. PubMed: 12086620
Comments:
 



Region 2
Type:Disordered
Name: 
Location:297 - 312
Length:16
Region sequence:

CKEGISDGATMKTFCG

Modification type:  
PDB: 1GZK:A, 1GZN:A
Structural/functional type:  
Functional classes:  
Functional subclasses:  
Detection methods:
 
References:
  1. Yang J, Cron P, Thompson V, Good VM, Hess D, Hemmings BA, Barford D. "Molecular mechanism for the regulation of protein kinase B/Akt by hydrophobic motif phosphorylation." Mol Cell. 2002; 9(6): 1227-40. PubMed: 12086620
Comments:
 



Region 3
Type:Disordered
Name: 
Location:442 - 460
Length:19
Region sequence:

EFTAQSITITPPDRYDSLG

Modification type:  
PDB: 1GZK:A
Structural/functional type:  
Functional classes:  
Functional subclasses:  
Detection methods:
 
References:
  1. Yang J, Cron P, Thompson V, Good VM, Hess D, Hemmings BA, Barford D. "Molecular mechanism for the regulation of protein kinase B/Akt by hydrophobic motif phosphorylation." Mol Cell. 2002; 9(6): 1227-40. PubMed: 12086620
Comments:
 



Region 4
Type:Disordered
Name: 
Location:443 - 480
Length:38
Region sequence:

FTAQSITITPPDRYDSLGLLELDQRTHFPQFSYSASIR

Modification type:  
PDB: 1GZN:A
Structural/functional type:  
Functional classes:  
Functional subclasses:  
Detection methods:
 
References:
  1. Yang J, Cron P, Thompson V, Good VM, Hess D, Hemmings BA, Barford D. "Molecular mechanism for the regulation of protein kinase B/Akt by hydrophobic motif phosphorylation." Mol Cell. 2002; 9(6): 1227-40. PubMed: 12086620
Comments:
 



Region 5
Type:Disordered
Name: 
Location:143 - 146
Length:4
Region sequence:

ARAK

Modification type:  
PDB: 1MRV:A
Structural/functional type:  
Functional classes:  
Functional subclasses:  
Detection methods:
 
References:
  1. Huang X, Begley M, Morgenstern KA, Gu Y, Rose P, Zhao H, Zhu X. "Crystal structure of an inactive Akt2 kinase domain." Structure. 2003; 11(1): 21-30. PubMed: 12517337
Comments:
 



Region 6
Type:Disordered
Name: 
Location:189 - 202
Length:14
Region sequence:

IAKDEVAHTVTESR

Modification type:  
PDB: 1MRV:A
Structural/functional type:  
Functional classes:  
Functional subclasses:  
Detection methods:
 
References:
  1. Huang X, Begley M, Morgenstern KA, Gu Y, Rose P, Zhao H, Zhu X. "Crystal structure of an inactive Akt2 kinase domain." Structure. 2003; 11(1): 21-30. PubMed: 12517337
Comments:
 



Region 7
Type:Disordered
Name: 
Location:295 - 313
Length:19
Region sequence:

GLCKEGISDGATMKTFCGT

Modification type:  
PDB: 1MRV:A
Structural/functional type:  
Functional classes:  
Functional subclasses:  
Detection methods:
 
References:
  1. Huang X, Begley M, Morgenstern KA, Gu Y, Rose P, Zhao H, Zhu X. "Crystal structure of an inactive Akt2 kinase domain." Structure. 2003; 11(1): 21-30. PubMed: 12517337
Comments:
 



Region 8
Type:Disordered
Name: 
Location:441 - 481
Length:41
Region sequence:

DEFTAQSITITPPDRYDSLGLLELDQRTHFPQFSYSASIRE

Modification type:  
PDB: 1MRV:A, 1MRY:A
Structural/functional type:  
Functional classes:  
Functional subclasses:  
Detection methods:
 
References:
  1. Huang X, Begley M, Morgenstern KA, Gu Y, Rose P, Zhao H, Zhu X. "Crystal structure of an inactive Akt2 kinase domain." Structure. 2003; 11(1): 21-30. PubMed: 12517337
Comments:
 



Region 9
Type:Disordered
Name: 
Location:143 - 145
Length:3
Region sequence:

ARA

Modification type:  
PDB: 1MRY:A
Structural/functional type:  
Functional classes:  
Functional subclasses:  
Detection methods:
 
References:
  1. Huang X, Begley M, Morgenstern KA, Gu Y, Rose P, Zhao H, Zhu X. "Crystal structure of an inactive Akt2 kinase domain." Structure. 2003; 11(1): 21-30. PubMed: 12517337
Comments:
 



Region 10
Type:Disordered
Name: 
Location:190 - 201
Length:12
Region sequence:

AKDEVAHTVTES

Modification type:  
PDB: 1MRY:A
Structural/functional type:  
Functional classes:  
Functional subclasses:  
Detection methods:
 
References:
  1. Huang X, Begley M, Morgenstern KA, Gu Y, Rose P, Zhao H, Zhu X. "Crystal structure of an inactive Akt2 kinase domain." Structure. 2003; 11(1): 21-30. PubMed: 12517337
Comments:
 



Region 11
Type:Disordered
Name: 
Location:298 - 310
Length:13
Region sequence:

KEGISDGATMKTF

Modification type:  
PDB: 1MRY:A
Structural/functional type:  
Functional classes:  
Functional subclasses:  
Detection methods:
 
References:
  1. Huang X, Begley M, Morgenstern KA, Gu Y, Rose P, Zhao H, Zhu X. "Crystal structure of an inactive Akt2 kinase domain." Structure. 2003; 11(1): 21-30. PubMed: 12517337
Comments:
 



Comments


This disordered protein entry is based solely on missing electron density in the Protein Data Bank.


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