| General information | | DisProt: | DP00307 | | Name: | Cyclin-H | | Synonym(s): | CCNH_HUMAN
MO15-associated protein
p37
p34
| | First appeared in release: | Release 3.1 (03/31/2006) | | UniProt: | P51946 | | UniGene: | Hs.292524 | | SwissProt: | CCNH_HUMAN | | TrEMBL: | | | NCBI (GI): | 1706232 | | Source organism: | Homo sapiens (Human) | | Sequence length: | 323 | | Percent disordered: | 14% | | Homologues: | |
| Native sequence |
10 20 30 40 50 60
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MYHNSSQKRH WTFSSEEQLA RLRADANRKF RCKAVANGKV LPNDPVFLEP HEEMTLCKYY - 60
EKRLLEFCSV FKPAMPRSVV GTACMYFKRF YLNNSVMEYH PRIIMLTCAF LACKVDEFNV - 120
SSPQFVGNLR ESPLGQEKAL EQILEYELLL IQQLNFHLIV HNPYRPFEGF LIDLKTRYPI - 180
LENPEILRKT ADDFLNRIAL TDAYLLYTPS QIALTAILSS ASRAGITMES YLSESLMLKE - 240
NRTCLSQLLD IMKSMRNLVK KYEPPRSEEV AVLKQKLERC HSAELALNVI TKKRKGYEDD - 300
DYVSKKSKHE EEEWTDDDLV ESL
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| Functional narrative |
Regulates CDK7, the catalytic subunit of the CDK-activating kinase (CAK) enzymatic complex. CAK activates the cyclin-associated kinases CDC2/CDK1, CDK2, CDK4 and CDK6 by threonine phosphorylation. CAK complexed to the core-TFIIH basal transcription factor activates RNA polymerase II by serine phosphorylation of the repetitive C-terminus domain (CTD) of its large subunit (POLR2A), allowing its escape from the promoter and elongation of the transcripts. Involved in cell cycle control and in RNA transcription by RNA polymerase II. Its expression and activity are constant throughout the cell cycle.
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| Map of ordered and disordered regions |
Note: 'Mouse' over a region to see the start and stop residues. Click on a region to see detailed information.
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| Region 1 | | Type: | Disordered | | Name: | | | Location: | 1 - 10 | | Length: | 10 | | Region sequence: |
MYHNSSQKRH | | Modification type: | | | PDB: | | | Structural/functional type: | Relationship to function unknown
| | Functional classes: | Unknown
| | Functional subclasses: | Unknown
| Detection methods:
- X-ray crystallography (277 K; pH: 5.8; ammonium phosphate 1 M; beta-ME 10 mM; glycerol 2 %; sodium citrate 0.1 M)
| References:
- Andersen G, Poterszman A, Egly JM, Moras D, Thierry JC. "The crystal structure of human cyclin H." FEBS Lett. 1996; 397(1): 65-9. PubMed: 8941715
| Comments:
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| Region 2 | | Type: | Disordered | | Name: | | | Location: | 288 - 323 | | Length: | 36 | | Region sequence: |
NVITKKRKGYEDDDYVSKKSKHEEEEWTDDDLVESL | | Modification type: | | | PDB: | | | Structural/functional type: | Relationship to function unknown
| | Functional classes: | Unknown
| | Functional subclasses: | Unknown
| Detection methods:
- X-ray crystallography (277 K; pH: 5.8; ammonium phosphate 1 M; beta-ME 10 mM; glycerol 2 %; sodium citrate 0.1 M)
| References:
- Andersen G, Poterszman A, Egly JM, Moras D, Thierry JC. "The crystal structure of human cyclin H." FEBS Lett. 1996; 397(1): 65-9. PubMed: 8941715
| Comments:
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| If you have any comments or wish to provide additional references to this protein or its disordered region(s), please click here to e-mail us. |
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