General information | DisProt: | DP00309 | Name: | Epidermal growth factor receptor [Isoform 1] | Synonym(s): | EGFR_HUMAN
Receptor tyrosine-protein kinase ErbB-1
EC=2.7.10.1
p170
| First appeared in release: | Release 3.0 (02/17/2006) | UniProt: | P00533-1 | UniGene: | Hs.488293 | SwissProt: | EGFR_HUMAN | TrEMBL: | | NCBI (GI): | 2811086 | Source organism: | Homo sapiens (Human) | Sequence length: | 1210 | Percent disordered: | 2% | Homologues: | |
Native sequence |
10 20 30 40 50 60 | | | | | | MRPSGTAGAA LLALLAALCP ASRALEEKKV CQGTSNKLTQ LGTFEDHFLS LQRMFNNCEV - 60 VLGNLEITYV QRNYDLSFLK TIQEVAGYVL IALNTVERIP LENLQIIRGN MYYENSYALA - 120 VLSNYDANKT GLKELPMRNL QEILHGAVRF SNNPALCNVE SIQWRDIVSS DFLSNMSMDF - 180 QNHLGSCQKC DPSCPNGSCW GAGEENCQKL TKIICAQQCS GRCRGKSPSD CCHNQCAAGC - 240 TGPRESDCLV CRKFRDEATC KDTCPPLMLY NPTTYQMDVN PEGKYSFGAT CVKKCPRNYV - 300 VTDHGSCVRA CGADSYEMEE DGVRKCKKCE GPCRKVCNGI GIGEFKDSLS INATNIKHFK - 360 NCTSISGDLH ILPVAFRGDS FTHTPPLDPQ ELDILKTVKE ITGFLLIQAW PENRTDLHAF - 420 ENLEIIRGRT KQHGQFSLAV VSLNITSLGL RSLKEISDGD VIISGNKNLC YANTINWKKL - 480 FGTSGQKTKI ISNRGENSCK ATGQVCHALC SPEGCWGPEP RDCVSCRNVS RGRECVDKCN - 540 LLEGEPREFV ENSECIQCHP ECLPQAMNIT CTGRGPDNCI QCAHYIDGPH CVKTCPAGVM - 600 GENNTLVWKY ADAGHVCHLC HPNCTYGCTG PGLEGCPTNG PKIPSIATGM VGALLLLLVV - 660 ALGIGLFMRR RHIVRKRTLR RLLQERELVE PLTPSGEAPN QALLRILKET EFKKIKVLGS - 720 GAFGTVYKGL WIPEGEKVKI PVAIKELREA TSPKANKEIL DEAYVMASVD NPHVCRLLGI - 780 CLTSTVQLIT QLMPFGCLLD YVREHKDNIG SQYLLNWCVQ IAKGMNYLED RRLVHRDLAA - 840 RNVLVKTPQH VKITDFGLAK LLGAEEKEYH AEGGKVPIKW MALESILHRI YTHQSDVWSY - 900 GVTVWELMTF GSKPYDGIPA SEISSILEKG ERLPQPPICT IDVYMIMVKC WMIDADSRPK - 960 FRELIIEFSK MARDPQRYLV IQGDERMHLP SPTDSNFYRA LMDEEDMDDV VDADEYLIPQ - 1020 QGFFSSPSTS RTPLLSSLSA TSNNSTVACI DRNGLQSCPI KEDSFLQRYS SDPTGALTED - 1080 SIDDTFLPVP EYINQSVPKR PAGSVQNPVY HNQPLNPAPS RDPHYQDPHS TAVGNPEYLN - 1140 TVQPTCVNST FDSPAHWAQK GSHQISLDNP DYQQDFFPKE AKPNGIFKGS TAENAEYLRV - 1200 APQSSEFIGA
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Functional narrative |
Receptor for EGF, but also for other members of the EGF family, as TGF-alpha, amphiregulin, betacellulin, heparin-binding EGF-like growth factor, GP30 and vaccinia virus growth factor. Is involved in the control of cell growth and differentiation. Phosphorylates MUC1 in breast cancer cells and increases the interaction of MUC1 with SRC and CTNNB1/beta-catenin.
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Map of ordered and disordered regions |
Note: 'Mouse' over a region to see the start and stop residues. Click on a region to see detailed information.
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Region 1 | Type: | Disordered | Name: | | Location: | 666 - 671 | Length: | 6 | Region sequence: |
LFMRRR | Modification type: | | PDB: | 1M14:A | Structural/functional type: | | Functional classes: | | Functional subclasses: | | Detection methods: | References:
- Stamos J, Sliwkowski MX, Eigenbrot C. "Structure of the epidermal growth factor receptor kinase domain alone and in complex with a 4-anilinoquinazoline inhibitor." J Biol Chem. 2002; 277(48): 46265-72. PubMed: 12196540
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Region 2 | Type: | Disordered | Name: | | Location: | 961 - 978 | Length: | 18 | Region sequence: |
FRELIIEFSKMARDPQRY | Modification type: | | PDB: | 1M14:A | Structural/functional type: | | Functional classes: | | Functional subclasses: | | Detection methods: | References:
- Stamos J, Sliwkowski MX, Eigenbrot C. "Structure of the epidermal growth factor receptor kinase domain alone and in complex with a 4-anilinoquinazoline inhibitor." J Biol Chem. 2002; 277(48): 46265-72. PubMed: 12196540
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Region 3 | Type: | Disordered | Name: | | Location: | 997 - 998 | Length: | 2 | Region sequence: |
FY | Modification type: | | PDB: | | Structural/functional type: | | Functional classes: | | Functional subclasses: | | Detection methods: | References:
- Stamos J, Sliwkowski MX, Eigenbrot C. "Structure of the epidermal growth factor receptor kinase domain alone and in complex with a 4-anilinoquinazoline inhibitor." J Biol Chem. 2002; 277(48): 46265-72. PubMed: 12196540
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Comments |
This disordered protein entry is based solely on missing electron density in the Protein Data Bank.
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If you have any comments or wish to provide additional references to this protein or its disordered region(s), please click here to e-mail us. |
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