| General information | | DisProt: | DP00310 | | Name: | Eukaryotic peptide chain release factor subunit 1 | | Synonym(s): | ERF1_HUMAN
Eukaryotic release factor 1
eRF1
TB3-1
Protein Cl1
| | First appeared in release: | Release 3.0 (02/17/2006) | | UniProt: | P62495 | | UniGene: | Hs.483494 | | SwissProt: | ERF1_HUMAN | | TrEMBL: | | | NCBI (GI): | 50402099 | | Source organism: | Homo sapiens (Human) | | Sequence length: | 437 | | Percent disordered: | 9% | | Homologues: | |
| Native sequence |
10 20 30 40 50 60
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MADDPSAADR NVEIWKIKKL IKSLEAARGN GTSMISLIIP PKDQISRVAK MLADEFGTAS - 60
NIKSRVNRLS VLGAITSVQQ RLKLYNKVPP NGLVVYCGTI VTEEGKEKKV NIDFEPFKPI - 120
NTSLYLCDNK FHTEALTALL SDDSKFGFIV IDGSGALFGT LQGNTREVLH KFTVDLPKKH - 180
GRGGQSALRF ARLRMEKRHN YVRKVAETAV QLFISGDKVN VAGLVLAGSA DFKTELSQSD - 240
MFDQRLQSKV LKLVDISYGG ENGFNQAIEL STEVLSNVKF IQEKKLIGRY FDEISQDTGK - 300
YCFGVEDTLK ALEMGAVEIL IVYENLDIMR YVLHCQGTEE EKILYLTPEQ EKDKSHFTDK - 360
ETGQEHELIE SMPLLEWFAN NYKKFGATLE IVTDKSQEGS QFVKGFGGIG GILRYRVDFQ - 420
GMEYQGGDDE FFDLDDY
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| Functional narrative |
Directs the termination of nascent peptide synthesis (translation) in response to the termination codons UAA, UAG and UGA.
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| Map of ordered and disordered regions |
Note: 'Mouse' over a region to see the start and stop residues. Click on a region to see detailed information.
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| Region 1 | | Type: | Disordered | | Name: | | | Location: | 1 - 4 | | Length: | 4 | | Region sequence: |
MADD | | Modification type: | | | PDB: | 1DT9:A | | Structural/functional type: | | | Functional classes: | | | Functional subclasses: | | Detection methods:
| References:
- Song H, Mugnier P, Das AK, Webb HM, Evans DR, Tuite MF, Hemmings BA, Barford D. "The crystal structure of human eukaryotic release factor eRF1--mechanism of stop codon recognition and peptidyl-tRNA hydrolysis." Cell. 2000; 100(3): 311-21. PubMed: 10676813
| Comments:
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| Region 2 | | Type: | Disordered | | Name: | | | Location: | 334 - 342 | | Length: | 9 | | Region sequence: |
HCQGTEEEK | | Modification type: | | | PDB: | 1DT9:A | | Structural/functional type: | | | Functional classes: | | | Functional subclasses: | | Detection methods:
| References:
- Song H, Mugnier P, Das AK, Webb HM, Evans DR, Tuite MF, Hemmings BA, Barford D. "The crystal structure of human eukaryotic release factor eRF1--mechanism of stop codon recognition and peptidyl-tRNA hydrolysis." Cell. 2000; 100(3): 311-21. PubMed: 10676813
| Comments:
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| Region 3 | | Type: | Disordered | | Name: | | | Location: | 359 - 369 | | Length: | 11 | | Region sequence: |
DKETGQEHELI | | Modification type: | | | PDB: | 1DT9:A | | Structural/functional type: | | | Functional classes: | | | Functional subclasses: | | Detection methods:
| References:
- Song H, Mugnier P, Das AK, Webb HM, Evans DR, Tuite MF, Hemmings BA, Barford D. "The crystal structure of human eukaryotic release factor eRF1--mechanism of stop codon recognition and peptidyl-tRNA hydrolysis." Cell. 2000; 100(3): 311-21. PubMed: 10676813
| Comments:
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| Region 4 | | Type: | Disordered | | Name: | | | Location: | 423 - 437 | | Length: | 15 | | Region sequence: |
EYQGGDDEFFDLDDY | | Modification type: | | | PDB: | 1DT9:A | | Structural/functional type: | | | Functional classes: | | | Functional subclasses: | | Detection methods:
| References:
- Song H, Mugnier P, Das AK, Webb HM, Evans DR, Tuite MF, Hemmings BA, Barford D. "The crystal structure of human eukaryotic release factor eRF1--mechanism of stop codon recognition and peptidyl-tRNA hydrolysis." Cell. 2000; 100(3): 311-21. PubMed: 10676813
| Comments:
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| Comments |
This disordered protein entry is based solely on missing electron density in the Protein Data Bank.
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| If you have any comments or wish to provide additional references to this protein or its disordered region(s), please click here to e-mail us. |
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