| General information | | DisProt: | DP00312 | | Name: | FL cytokine receptor | | Synonym(s): | FLT3_HUMAN
EC=2.7.10.1
Tyrosine-protein kinase receptor FLT3
Stem cell tyrosine kinase 1
STK-1
Antigen CD135
| | First appeared in release: | Release 3.0 (02/17/2006) | | UniProt: | P36888 | | UniGene: | Hs.507590 | | SwissProt: | FLT3_HUMAN | | TrEMBL: | | | NCBI (GI): | 156630887 | | Source organism: | Homo sapiens (Human) | | Sequence length: | 993 | | Percent disordered: | 5% | | Homologues: | |
| Native sequence |
10 20 30 40 50 60
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MPALARDAGT VPLLVVFSAM IFGTITNQDL PVIKCVLINH KNNDSSVGKS SSYPMVSESP - 60
EDLGCALRPQ SSGTVYEAAA VEVDVSASIT LQVLVDAPGN ISCLWVFKHS SLNCQPHFDL - 120
QNRGVVSMVI LKMTETQAGE YLLFIQSEAT NYTILFTVSI RNTLLYTLRR PYFRKMENQD - 180
ALVCISESVP EPIVEWVLCD SQGESCKEES PAVVKKEEKV LHELFGTDIR CCARNELGRE - 240
CTRLFTIDLN QTPQTTLPQL FLKVGEPLWI RCKAVHVNHG FGLTWELENK ALEEGNYFEM - 300
STYSTNRTMI RILFAFVSSV ARNDTGYYTC SSSKHPSQSA LVTIVGKGFI NATNSSEDYE - 360
IDQYEEFCFS VRFKAYPQIR CTWTFSRKSF PCEQKGLDNG YSISKFCNHK HQPGEYIFHA - 420
ENDDAQFTKM FTLNIRRKPQ VLAEASASQA SCFSDGYPLP SWTWKKCSDK SPNCTEEITE - 480
GVWNRKANRK VFGQWVSSST LNMSEAIKGF LVKCCAYNSL GTSCETILLN SPGPFPFIQD - 540
NISFYATIGV CLLFIVVLTL LICHKYKKQF RYESQLQMVQ VTGSSDNEYF YVDFREYEYD - 600
LKWEFPRENL EFGKVLGSGA FGKVMNATAY GISKTGVSIQ VAVKMLKEKA DSSEREALMS - 660
ELKMMTQLGS HENIVNLLGA CTLSGPIYLI FEYCCYGDLL NYLRSKREKF HRTWTEIFKE - 720
HNFSFYPTFQ SHPNSSMPGS REVQIHPDSD QISGLHGNSF HSEDEIEYEN QKRLEEEEDL - 780
NVLTFEDLLC FAYQVAKGME FLEFKSCVHR DLAARNVLVT HGKVVKICDF GLARDIMSDS - 840
NYVVRGNARL PVKWMAPESL FEGIYTIKSD VWSYGILLWE IFSLGVNPYP GIPVDANFYK - 900
LIQNGFKMDQ PFYATEEIYI IMQSCWAFDS RKRPSFPNLT SFLGCQLADA EEAMYQNVDG - 960
RVSECPHTYQ NRRPFSREMD LGLLSPQAQV EDS
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| Functional narrative |
Receptor for the FL cytokine. Has a tyrosine-protein kinase activity.
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| Map of ordered and disordered regions |
Note: 'Mouse' over a region to see the start and stop residues. Click on a region to see detailed information.
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| Region 1 | | Type: | Disordered | | Name: | | | Location: | 564 - 571 | | Length: | 8 | | Region sequence: |
HKYKKQFR | | Modification type: | | | PDB: | 1RJB:A | | Structural/functional type: | | | Functional classes: | | | Functional subclasses: | | Detection methods:
| References:
- Griffith J, Black J, Faerman C, Swenson L, Wynn M, Lu F, Lippke J, Saxena K. "The structural basis for autoinhibition of FLT3 by the juxtamembrane domain." Mol Cell. 2004; 13(2): 169-78. PubMed: 14759363
| Comments:
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| Region 2 | | Type: | Disordered | | Name: | | | Location: | 649 - 654 | | Length: | 6 | | Region sequence: |
KADSSE | | Modification type: | | | PDB: | 1RJB:A | | Structural/functional type: | | | Functional classes: | | | Functional subclasses: | | Detection methods:
| References:
- Griffith J, Black J, Faerman C, Swenson L, Wynn M, Lu F, Lippke J, Saxena K. "The structural basis for autoinhibition of FLT3 by the juxtamembrane domain." Mol Cell. 2004; 13(2): 169-78. PubMed: 14759363
| Comments:
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| Region 3 | | Type: | Disordered | | Name: | | | Location: | 762 - 782 | | Length: | 21 | | Region sequence: |
SEDEIEYENQKRLEEEEDLNV | | Modification type: | | | PDB: | 1RJB:A | | Structural/functional type: | | | Functional classes: | | | Functional subclasses: | | Detection methods:
| References:
- Griffith J, Black J, Faerman C, Swenson L, Wynn M, Lu F, Lippke J, Saxena K. "The structural basis for autoinhibition of FLT3 by the juxtamembrane domain." Mol Cell. 2004; 13(2): 169-78. PubMed: 14759363
| Comments:
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| Region 4 | | Type: | Disordered | | Name: | | | Location: | 948 - 958 | | Length: | 11 | | Region sequence: |
ADAEEAMYQNV | | Modification type: | | | PDB: | 1RJB:A | | Structural/functional type: | | | Functional classes: | | | Functional subclasses: | | Detection methods:
| References:
- Griffith J, Black J, Faerman C, Swenson L, Wynn M, Lu F, Lippke J, Saxena K. "The structural basis for autoinhibition of FLT3 by the juxtamembrane domain." Mol Cell. 2004; 13(2): 169-78. PubMed: 14759363
| Comments:
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| Comments |
This disordered protein entry is based solely on missing electron density in the Protein Data Bank.
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| If you have any comments or wish to provide additional references to this protein or its disordered region(s), please click here to e-mail us. |
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