Annotation for this protein is in progress - please check future releases for more complete information


DP00314: ADP-ribosylation factor-binding protein GGA1 [Isoform 1]FASTA viewXML view

General information
DisProt:DP00314
Name:ADP-ribosylation factor-binding protein GGA1 [Isoform 1]
Synonym(s):GGA1_HUMAN
Golgi-localized, gamma ear-containing, ARF-binding protein 1
Gamma-adaptin-related protein 1
First appeared in release:Release 3.0 (02/17/2006)
UniProt:Q9UJY5-1
UniGene:Hs.499158
SwissProt: GGA1_HUMAN
TrEMBL:  
NCBI (GI): 14548066
Source organism:Homo sapiens (Human)
Sequence length:639
Percent disordered:13%
Homologues: 


Native sequence

        10         20         30         40         50         60
         |          |          |          |          |          |
MEPAMEPETL EARINRATNP LNKELDWASI NGFCEQLNED FEGPPLATRL LAHKIQSPQE - 60
WEAIQALTVL ETCMKSCGKR FHDEVGKFRF LNELIKVVSP KYLGSRTSEK VKNKILELLY - 120
SWTVGLPEEV KIAEAYQMLK KQGIVKSDPK LPDDTTFPLP PPRPKNVIFE DEEKSKMLAR - 180
LLKSSHPEDL RAANKLIKEM VQEDQKRMEK ISKRVNAIEE VNNNVKLLTE MVMSHSQGGA - 240
AAGSSEDLMK ELYQRCERMR PTLFRLASDT EDNDEALAEI LQANDNLTQV INLYKQLVRG - 300
EEVNGDATAG SIPGSTSALL DLSGLDLPPA GTTYPAMPTR PGEQASPEQP SASVSLLDDE - 360
LMSLGLSDPT PPSGPSLDGT GWNSFQSSDA TEPPAPALAQ APSMESRPPA QTSLPASSGL - 420
DDLDLLGKTL LQQSLPPESQ QVRWEKQQPT PRLTLRDLQN KSSSCSSPSS SATSLLHTVS - 480
PEPPRPPQQP VPTELSLASI TVPLESIKPS NILPVTVYDQ HGFRILFHFA RDPLPGRSDV - 540
LVVVVSMLST APQPIRNIVF QSAVPKVMKV KLQPPSGTEL PAFNPIVHPS AITQVLLLAN - 600
PQKEKVRLRY KLTFTMGDQT YNEMGDVDQF PPPETWGSL



Functional narrative    

Plays a role in protein sorting and trafficking between the trans-Golgi network (TGN) and endosomes. Mediates the ARF-dependent recruitment of clathrin to the TGN and binds ubiquitinated proteins and membrane cargo molecules with a cytosolic acidic cluster-dileucine (AC-LL) motif.

Region 6: 141-170 Region 1: 166-189 Region 4: 166-191 Region 2: 237-243 Region 3: 302-302 Region 5: 304-305 Region 7: 303-326

Map of ordered and disordered regions







Note: 'Mouse' over a region to see the start and stop residues. Click on a region to see detailed information.


Region 1
Type:Disordered
Name: 
Location:166 - 189
Length:24
Region sequence:

NVIFEDEEKSKMLARLLKSSHPED

Modification type:  
PDB: 1NWM:A
Structural/functional type:  
Functional classes:  
Functional subclasses:  
Detection methods:
 
References:
  1. Suer S, Misra S, Saidi LF, Hurley JH. "Structure of the GAT domain of human GGA1: a syntaxin amino-terminal domain fold in an endosomal trafficking adaptor." Proc Natl Acad Sci U S A. 2003; 100(8): 4451-6. PubMed: 12668765
Comments:
The PDB file contains an additional 5 amino acid insert consisting of GAMGS at the N-terminus of this region.


Region 2
Type:Disordered
Name: 
Location:237 - 243
Length:7
Region sequence:

QGGAAAG

Modification type:  
PDB: 1NWM:A
Structural/functional type:  
Functional classes:  
Functional subclasses:  
Detection methods:
 
References:
  1. Suer S, Misra S, Saidi LF, Hurley JH. "Structure of the GAT domain of human GGA1: a syntaxin amino-terminal domain fold in an endosomal trafficking adaptor." Proc Natl Acad Sci U S A. 2003; 100(8): 4451-6. PubMed: 12668765
Comments:
 



Region 3
Type:Disordered
Name: 
Location:302 - 302
Length:1
Region sequence:

E

Modification type:  
PDB: 1NWM:A
Structural/functional type:  
Functional classes:  
Functional subclasses:  
Detection methods:
 
References:
  1. Suer S, Misra S, Saidi LF, Hurley JH. "Structure of the GAT domain of human GGA1: a syntaxin amino-terminal domain fold in an endosomal trafficking adaptor." Proc Natl Acad Sci U S A. 2003; 100(8): 4451-6. PubMed: 12668765
Comments:
 



Region 4
Type:Disordered
Name: 
Location:166 - 191
Length:26
Region sequence:

NVIFEDEEKSKMLARLLKSSHPEDLR

Modification type:  
PDB: 1O3X:A
Structural/functional type:  
Functional classes:  
Functional subclasses:  
Detection methods:
 
References:
  1. Shiba T, Kawasaki M, Takatsu H, Nogi T, Matsugaki N, Igarashi N, Suzuki M, Kato R, Nakayama K, Wakatsuki S. "Molecular mechanism of membrane recruitment of GGA by ARF in lysosomal protein transport." Nat Struct Biol. 2003; 10(5): 386-93. PubMed: 12679809
Comments:
 



Region 5
Type:Disordered
Name: 
Location:304 - 305
Length:2
Region sequence:

NG

Modification type:  
PDB: 1O3X:A
Structural/functional type:  
Functional classes:  
Functional subclasses:  
Detection methods:
 
References:
  1. Shiba T, Kawasaki M, Takatsu H, Nogi T, Matsugaki N, Igarashi N, Suzuki M, Kato R, Nakayama K, Wakatsuki S. "Molecular mechanism of membrane recruitment of GGA by ARF in lysosomal protein transport." Nat Struct Biol. 2003; 10(5): 386-93. PubMed: 12679809
Comments:
 



Region 6
Type:Disordered
Name: 
Location:141 - 170
Length:30
Region sequence:

KQGIVKSDPKLPDDTTFPLPPPRPKNVIFE

Modification type:  
PDB: 1OXZ:A
Structural/functional type:  
Functional classes:  
Functional subclasses:  
Detection methods:
 
References:
  1. Zhu G, Zhai P, He X, Terzyan S, Zhang R, Joachimiak A, Tang J, Zhang XC. "Crystal structure of the human GGA1 GAT domain." Biochemistry. 2003; 42(21): 6392-9. PubMed: 12767220
Comments:
 



Region 7
Type:Disordered
Name: 
Location:303 - 326
Length:24
Region sequence:

VNGDATAGSIPGSTSALLDLSGLD

Modification type:  
PDB: 1OXZ:A
Structural/functional type:  
Functional classes:  
Functional subclasses:  
Detection methods:
 
References:
  1. Zhu G, Zhai P, He X, Terzyan S, Zhang R, Joachimiak A, Tang J, Zhang XC. "Crystal structure of the human GGA1 GAT domain." Biochemistry. 2003; 42(21): 6392-9. PubMed: 12767220
Comments:
 



Comments


This disordered protein entry is based solely on missing electron density in the Protein Data Bank.


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