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DP00317: Hepatocyte growth factor receptor [Isoform 1]FASTA viewXML view

General information
DisProt:DP00317
Name:Hepatocyte growth factor receptor [Isoform 1]
Synonym(s):MET_HUMAN
HGF receptor
EC=2.7.10.1
Scatter factor receptor
SF receptor
HGF/SF receptor
Met proto-oncogene tyrosine kinase
c-Met
First appeared in release:Release 3.0 (02/17/2006)
UniProt:P08581-1
UniGene:Hs.132966
SwissProt: MET_HUMAN
TrEMBL:  
NCBI (GI): 251757497
Source organism:Homo sapiens (Human)
Sequence length:1390
Percent disordered:6%
Homologues: 


Native sequence

        10         20         30         40         50         60
         |          |          |          |          |          |
MKAPAVLAPG ILVLLFTLVQ RSNGECKEAL AKSEMNVNMK YQLPNFTAET PIQNVILHEH - 60
HIFLGATNYI YVLNEEDLQK VAEYKTGPVL EHPDCFPCQD CSSKANLSGG VWKDNINMAL - 120
VVDTYYDDQL ISCGSVNRGT CQRHVFPHNH TADIQSEVHC IFSPQIEEPS QCPDCVVSAL - 180
GAKVLSSVKD RFINFFVGNT INSSYFPDHP LHSISVRRLK ETKDGFMFLT DQSYIDVLPE - 240
FRDSYPIKYV HAFESNNFIY FLTVQRETLD AQTFHTRIIR FCSINSGLHS YMEMPLECIL - 300
TEKRKKRSTK KEVFNILQAA YVSKPGAQLA RQIGASLNDD ILFGVFAQSK PDSAEPMDRS - 360
AMCAFPIKYV NDFFNKIVNK NNVRCLQHFY GPNHEHCFNR TLLRNSSGCE ARRDEYRTEF - 420
TTALQRVDLF MGQFSEVLLT SISTFIKGDL TIANLGTSEG RFMQVVVSRS GPSTPHVNFL - 480
LDSHPVSPEV IVEHTLNQNG YTLVITGKKI TKIPLNGLGC RHFQSCSQCL SAPPFVQCGW - 540
CHDKCVRSEE CLSGTWTQQI CLPAIYKVFP NSAPLEGGTR LTICGWDFGF RRNNKFDLKK - 600
TRVLLGNESC TLTLSESTMN TLKCTVGPAM NKHFNMSIII SNGHGTTQYS TFSYVDPVIT - 660
SISPKYGPMA GGTLLTLTGN YLNSGNSRHI SIGGKTCTLK SVSNSILECY TPAQTISTEF - 720
AVKLKIDLAN RETSIFSYRE DPIVYEIHPT KSFISGGSTI TGVGKNLNSV SVPRMVINVH - 780
EAGRNFTVAC QHRSNSEIIC CTTPSLQQLN LQLPLKTKAF FMLDGILSKY FDLIYVHNPV - 840
FKPFEKPVMI SMGNENVLEI KGNDIDPEAV KGEVLKVGNK SCENIHLHSE AVLCTVPNDL - 900
LKLNSELNIE WKQAISSTVL GKVIVQPDQN FTGLIAGVVS ISTALLLLLG FFLWLKKRKQ - 960
IKDLGSELVR YDARVHTPHL DRLVSARSVS PTTEMVSNES VDYRATFPED QFPNSSQNGS - 1020
CRQVQYPLTD MSPILTSGDS DISSPLLQNT VHIDLSALNP ELVQAVQHVV IGPSSLIVHF - 1080
NEVIGRGHFG CVYHGTLLDN DGKKIHCAVK SLNRITDIGE VSQFLTEGII MKDFSHPNVL - 1140
SLLGICLRSE GSPLVVLPYM KHGDLRNFIR NETHNPTVKD LIGFGLQVAK GMKYLASKKF - 1200
VHRDLAARNC MLDEKFTVKV ADFGLARDMY DKEYYSVHNK TGAKLPVKWM ALESLQTQKF - 1260
TTKSDVWSFG VVLWELMTRG APPYPDVNTF DITVYLLQGR RLLQPEYCPD PLYEVMLKCW - 1320
HPKAEMRPSF SELVSRISAI FSTFIGEHYV HVNATYVNVK CVAPYPSLLS SEDNADDEVD - 1380
TRPASFWETS



Functional narrative    

Receptor for hepatocyte growth factor and scatter factor. Has a tyrosine-protein kinase activity. Functions in cell proliferation, scattering, morphogenesis and survival.

Region 5: 25-39 Region 6: 302-310 Region 7: 378-381 Region 8: 401-413 Region 9: 565-575 Region 1: 1049-1049 Region 2: 1099-1103 Region 3: 1231-1244 Region 4: 1286-1290

Map of ordered and disordered regions







Note: 'Mouse' over a region to see the start and stop residues. Click on a region to see detailed information.


Region 1
Type:Disordered
Name: 
Location:1049 - 1049
Length:1
Region sequence:

N

Modification type:  
PDB: 1R1W:A
Structural/functional type:  
Functional classes:  
Functional subclasses:  
Detection methods:
 
References:
  1. Schiering N, Knapp S, Marconi M, Flocco MM, Cui J, Perego R, Rusconi L, Cristiani C. "Crystal structure of the tyrosine kinase domain of the hepatocyte growth factor receptor c-Met and its complex with the microbial alkaloid K-252a." Proc Natl Acad Sci U S A. 2003; 100(22): 12654-9. PubMed: 14559966

Comments:
 



Region 2
Type:Disordered
Name: 
Location:1099 - 1103
Length:5
Region sequence:

DNDGK

Modification type:  
PDB: 1R1W:A
Structural/functional type:  
Functional classes:  
Functional subclasses:  
Detection methods:
 
References:
  1. Schiering N, Knapp S, Marconi M, Flocco MM, Cui J, Perego R, Rusconi L, Cristiani C. "Crystal structure of the tyrosine kinase domain of the hepatocyte growth factor receptor c-Met and its complex with the microbial alkaloid K-252a." Proc Natl Acad Sci U S A. 2003; 100(22): 12654-9. PubMed: 14559966

Comments:
 



Region 3
Type:Disordered
Name: 
Location:1231 - 1244
Length:14
Region sequence:

DKEYYSVHNKTGAK

Modification type:  
PDB: 1R1W:A
Structural/functional type:  
Functional classes:  
Functional subclasses:  
Detection methods:
 
References:
  1. Schiering N, Knapp S, Marconi M, Flocco MM, Cui J, Perego R, Rusconi L, Cristiani C. "Crystal structure of the tyrosine kinase domain of the hepatocyte growth factor receptor c-Met and its complex with the microbial alkaloid K-252a." Proc Natl Acad Sci U S A. 2003; 100(22): 12654-9. PubMed: 14559966

Comments:
 



Region 4
Type:Disordered
Name: 
Location:1286 - 1290
Length:5
Region sequence:

DVNTF

Modification type:  
PDB: 1R1W:A
Structural/functional type:  
Functional classes:  
Functional subclasses:  
Detection methods:
 
References:
  1. Schiering N, Knapp S, Marconi M, Flocco MM, Cui J, Perego R, Rusconi L, Cristiani C. "Crystal structure of the tyrosine kinase domain of the hepatocyte growth factor receptor c-Met and its complex with the microbial alkaloid K-252a." Proc Natl Acad Sci U S A. 2003; 100(22): 12654-9. PubMed: 14559966

Comments:
 



Region 5
Type:Disordered
Name: 
Location:25 - 39
Length:15
Region sequence:

ECKEALAKSEMNVNM

Modification type: Engineered
Mutant
PDB: 1SHY:B
Structural/functional type:  
Functional classes:  
Functional subclasses:  
Detection methods:
 
References:
  1. Stamos J, Lazarus RA, Yao X, Kirchhofer D, Wiesmann C. "Crystal structure of the HGF beta-chain in complex with the Sema domain of the Met receptor." Embo J. 2004; 23(12): 2325-35. PubMed: 15167892

Comments:
 



Region 6
Type:Disordered
Name: 
Location:302 - 310
Length:9
Region sequence:

EKRKKRSTK

Modification type: Engineered
Mutant
PDB: 1SHY:B
Structural/functional type:  
Functional classes:  
Functional subclasses:  
Detection methods:
 
References:
  1. Stamos J, Lazarus RA, Yao X, Kirchhofer D, Wiesmann C. "Crystal structure of the HGF beta-chain in complex with the Sema domain of the Met receptor." Embo J. 2004; 23(12): 2325-35. PubMed: 15167892

Comments:
 



Region 7
Type:Disordered
Name: 
Location:378 - 381
Length:4
Region sequence:

VNKN

Modification type: Engineered
Mutant
PDB: 1SHY:B
Structural/functional type:  
Functional classes:  
Functional subclasses:  
Detection methods:
 
References:
  1. Stamos J, Lazarus RA, Yao X, Kirchhofer D, Wiesmann C. "Crystal structure of the HGF beta-chain in complex with the Sema domain of the Met receptor." Embo J. 2004; 23(12): 2325-35. PubMed: 15167892

Comments:
 



Region 8
Type:Disordered
Name: 
Location:401 - 413
Length:13
Region sequence:

TLLRNSSGCEARR

Modification type: Engineered
Mutant
PDB: 1SHY:B
Structural/functional type:  
Functional classes:  
Functional subclasses:  
Detection methods:
 
References:
  1. Stamos J, Lazarus RA, Yao X, Kirchhofer D, Wiesmann C. "Crystal structure of the HGF beta-chain in complex with the Sema domain of the Met receptor." Embo J. 2004; 23(12): 2325-35. PubMed: 15167892

Comments:
 



Region 9
Type:Disordered
Name: 
Location:565 - 575
Length:11
Region sequence:

IYKVFPNSAPL

Modification type: Engineered
Mutant
PDB: 1SHY:B
Structural/functional type:  
Functional classes:  
Functional subclasses:  
Detection methods:
 
References:
  1. Stamos J, Lazarus RA, Yao X, Kirchhofer D, Wiesmann C. "Crystal structure of the HGF beta-chain in complex with the Sema domain of the Met receptor." Embo J. 2004; 23(12): 2325-35. PubMed: 15167892

Comments:
 



Comments


This disordered protein entry is based solely on missing electron density in the Protein Data Bank.


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