General information | DisProt: | DP00317 | Name: | Hepatocyte growth factor receptor [Isoform 1] | Synonym(s): | MET_HUMAN
HGF receptor
EC=2.7.10.1
Scatter factor receptor
SF receptor
HGF/SF receptor
Met proto-oncogene tyrosine kinase
c-Met
| First appeared in release: | Release 3.0 (02/17/2006) | UniProt: | P08581-1 | UniGene: | Hs.132966 | SwissProt: | MET_HUMAN | TrEMBL: | | NCBI (GI): | 251757497 | Source organism: | Homo sapiens (Human) | Sequence length: | 1390 | Percent disordered: | 6% | Homologues: | |
Native sequence |
10 20 30 40 50 60 | | | | | | MKAPAVLAPG ILVLLFTLVQ RSNGECKEAL AKSEMNVNMK YQLPNFTAET PIQNVILHEH - 60 HIFLGATNYI YVLNEEDLQK VAEYKTGPVL EHPDCFPCQD CSSKANLSGG VWKDNINMAL - 120 VVDTYYDDQL ISCGSVNRGT CQRHVFPHNH TADIQSEVHC IFSPQIEEPS QCPDCVVSAL - 180 GAKVLSSVKD RFINFFVGNT INSSYFPDHP LHSISVRRLK ETKDGFMFLT DQSYIDVLPE - 240 FRDSYPIKYV HAFESNNFIY FLTVQRETLD AQTFHTRIIR FCSINSGLHS YMEMPLECIL - 300 TEKRKKRSTK KEVFNILQAA YVSKPGAQLA RQIGASLNDD ILFGVFAQSK PDSAEPMDRS - 360 AMCAFPIKYV NDFFNKIVNK NNVRCLQHFY GPNHEHCFNR TLLRNSSGCE ARRDEYRTEF - 420 TTALQRVDLF MGQFSEVLLT SISTFIKGDL TIANLGTSEG RFMQVVVSRS GPSTPHVNFL - 480 LDSHPVSPEV IVEHTLNQNG YTLVITGKKI TKIPLNGLGC RHFQSCSQCL SAPPFVQCGW - 540 CHDKCVRSEE CLSGTWTQQI CLPAIYKVFP NSAPLEGGTR LTICGWDFGF RRNNKFDLKK - 600 TRVLLGNESC TLTLSESTMN TLKCTVGPAM NKHFNMSIII SNGHGTTQYS TFSYVDPVIT - 660 SISPKYGPMA GGTLLTLTGN YLNSGNSRHI SIGGKTCTLK SVSNSILECY TPAQTISTEF - 720 AVKLKIDLAN RETSIFSYRE DPIVYEIHPT KSFISGGSTI TGVGKNLNSV SVPRMVINVH - 780 EAGRNFTVAC QHRSNSEIIC CTTPSLQQLN LQLPLKTKAF FMLDGILSKY FDLIYVHNPV - 840 FKPFEKPVMI SMGNENVLEI KGNDIDPEAV KGEVLKVGNK SCENIHLHSE AVLCTVPNDL - 900 LKLNSELNIE WKQAISSTVL GKVIVQPDQN FTGLIAGVVS ISTALLLLLG FFLWLKKRKQ - 960 IKDLGSELVR YDARVHTPHL DRLVSARSVS PTTEMVSNES VDYRATFPED QFPNSSQNGS - 1020 CRQVQYPLTD MSPILTSGDS DISSPLLQNT VHIDLSALNP ELVQAVQHVV IGPSSLIVHF - 1080 NEVIGRGHFG CVYHGTLLDN DGKKIHCAVK SLNRITDIGE VSQFLTEGII MKDFSHPNVL - 1140 SLLGICLRSE GSPLVVLPYM KHGDLRNFIR NETHNPTVKD LIGFGLQVAK GMKYLASKKF - 1200 VHRDLAARNC MLDEKFTVKV ADFGLARDMY DKEYYSVHNK TGAKLPVKWM ALESLQTQKF - 1260 TTKSDVWSFG VVLWELMTRG APPYPDVNTF DITVYLLQGR RLLQPEYCPD PLYEVMLKCW - 1320 HPKAEMRPSF SELVSRISAI FSTFIGEHYV HVNATYVNVK CVAPYPSLLS SEDNADDEVD - 1380 TRPASFWETS
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Functional narrative |
Receptor for hepatocyte growth factor and scatter factor. Has a tyrosine-protein kinase activity. Functions in cell proliferation, scattering, morphogenesis and survival.
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Map of ordered and disordered regions |
Note: 'Mouse' over a region to see the start and stop residues. Click on a region to see detailed information.
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Region 1 | Type: | Disordered | Name: | | Location: | 1049 - 1049 | Length: | 1 | Region sequence: |
N | Modification type: | | PDB: | 1R1W:A | Structural/functional type: | | Functional classes: | | Functional subclasses: | | Detection methods: | References:
- Schiering N, Knapp S, Marconi M, Flocco MM, Cui J, Perego R, Rusconi L, Cristiani C. "Crystal structure of the tyrosine kinase domain of the hepatocyte growth factor receptor c-Met and its complex with the microbial alkaloid K-252a." Proc Natl Acad Sci U S A. 2003; 100(22): 12654-9. PubMed: 14559966
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Region 2 | Type: | Disordered | Name: | | Location: | 1099 - 1103 | Length: | 5 | Region sequence: |
DNDGK | Modification type: | | PDB: | 1R1W:A | Structural/functional type: | | Functional classes: | | Functional subclasses: | | Detection methods: | References:
- Schiering N, Knapp S, Marconi M, Flocco MM, Cui J, Perego R, Rusconi L, Cristiani C. "Crystal structure of the tyrosine kinase domain of the hepatocyte growth factor receptor c-Met and its complex with the microbial alkaloid K-252a." Proc Natl Acad Sci U S A. 2003; 100(22): 12654-9. PubMed: 14559966
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Region 3 | Type: | Disordered | Name: | | Location: | 1231 - 1244 | Length: | 14 | Region sequence: |
DKEYYSVHNKTGAK | Modification type: | | PDB: | 1R1W:A | Structural/functional type: | | Functional classes: | | Functional subclasses: | | Detection methods: | References:
- Schiering N, Knapp S, Marconi M, Flocco MM, Cui J, Perego R, Rusconi L, Cristiani C. "Crystal structure of the tyrosine kinase domain of the hepatocyte growth factor receptor c-Met and its complex with the microbial alkaloid K-252a." Proc Natl Acad Sci U S A. 2003; 100(22): 12654-9. PubMed: 14559966
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Region 4 | Type: | Disordered | Name: | | Location: | 1286 - 1290 | Length: | 5 | Region sequence: |
DVNTF | Modification type: | | PDB: | 1R1W:A | Structural/functional type: | | Functional classes: | | Functional subclasses: | | Detection methods: | References:
- Schiering N, Knapp S, Marconi M, Flocco MM, Cui J, Perego R, Rusconi L, Cristiani C. "Crystal structure of the tyrosine kinase domain of the hepatocyte growth factor receptor c-Met and its complex with the microbial alkaloid K-252a." Proc Natl Acad Sci U S A. 2003; 100(22): 12654-9. PubMed: 14559966
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Region 5 | Type: | Disordered | Name: | | Location: | 25 - 39 | Length: | 15 | Region sequence: |
ECKEALAKSEMNVNM | Modification type: | Engineered
Mutant
| PDB: | 1SHY:B | Structural/functional type: | | Functional classes: | | Functional subclasses: | | Detection methods: | References:
- Stamos J, Lazarus RA, Yao X, Kirchhofer D, Wiesmann C. "Crystal structure of the HGF beta-chain in complex with the Sema domain of the Met receptor." Embo J. 2004; 23(12): 2325-35. PubMed: 15167892
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Region 6 | Type: | Disordered | Name: | | Location: | 302 - 310 | Length: | 9 | Region sequence: |
EKRKKRSTK | Modification type: | Engineered
Mutant
| PDB: | 1SHY:B | Structural/functional type: | | Functional classes: | | Functional subclasses: | | Detection methods: | References:
- Stamos J, Lazarus RA, Yao X, Kirchhofer D, Wiesmann C. "Crystal structure of the HGF beta-chain in complex with the Sema domain of the Met receptor." Embo J. 2004; 23(12): 2325-35. PubMed: 15167892
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Region 7 | Type: | Disordered | Name: | | Location: | 378 - 381 | Length: | 4 | Region sequence: |
VNKN | Modification type: | Engineered
Mutant
| PDB: | 1SHY:B | Structural/functional type: | | Functional classes: | | Functional subclasses: | | Detection methods: | References:
- Stamos J, Lazarus RA, Yao X, Kirchhofer D, Wiesmann C. "Crystal structure of the HGF beta-chain in complex with the Sema domain of the Met receptor." Embo J. 2004; 23(12): 2325-35. PubMed: 15167892
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Region 8 | Type: | Disordered | Name: | | Location: | 401 - 413 | Length: | 13 | Region sequence: |
TLLRNSSGCEARR | Modification type: | Engineered
Mutant
| PDB: | 1SHY:B | Structural/functional type: | | Functional classes: | | Functional subclasses: | | Detection methods: | References:
- Stamos J, Lazarus RA, Yao X, Kirchhofer D, Wiesmann C. "Crystal structure of the HGF beta-chain in complex with the Sema domain of the Met receptor." Embo J. 2004; 23(12): 2325-35. PubMed: 15167892
| Comments:
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Region 9 | Type: | Disordered | Name: | | Location: | 565 - 575 | Length: | 11 | Region sequence: |
IYKVFPNSAPL | Modification type: | Engineered
Mutant
| PDB: | 1SHY:B | Structural/functional type: | | Functional classes: | | Functional subclasses: | | Detection methods: | References:
- Stamos J, Lazarus RA, Yao X, Kirchhofer D, Wiesmann C. "Crystal structure of the HGF beta-chain in complex with the Sema domain of the Met receptor." Embo J. 2004; 23(12): 2325-35. PubMed: 15167892
| Comments:
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Comments |
This disordered protein entry is based solely on missing electron density in the Protein Data Bank.
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If you have any comments or wish to provide additional references to this protein or its disordered region(s), please click here to e-mail us. |
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