| General information | | DisProt: | DP00319 | | Name: | Tumor protein p73 [Isoform Alpha] | | Synonym(s): | P73_HUMAN
p53-like transcription factor
p53-related protein
| | First appeared in release: | Release 3.0 (02/17/2006) | | UniProt: | O15350-1 | | UniGene: | Hs.697294 | | SwissProt: | P73_HUMAN | | TrEMBL: | | | NCBI (GI): | 8928244 | | Source organism: | Homo sapiens (Human) | | Sequence length: | 636 | | Percent disordered: | 3% | | Homologues: | |
| Native sequence |
10 20 30 40 50 60
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MAQSTATSPD GGTTFEHLWS SLEPDSTYFD LPQSSRGNNE VVGGTDSSMD VFHLEGMTTS - 60
VMAQFNLLSS TMDQMSSRAA SASPYTPEHA ASVPTHSPYA QPSSTFDTMS PAPVIPSNTD - 120
YPGPHHFEVT FQQSSTAKSA TWTYSPLLKK LYCQIAKTCP IQIKVSTPPP PGTAIRAMPV - 180
YKKAEHVTDV VKRCPNHELG RDFNEGQSAP ASHLIRVEGN NLSQYVDDPV TGRQSVVVPY - 240
EPPQVGTEFT TILYNFMCNS SCVGGMNRRP ILIIITLEMR DGQVLGRRSF EGRICACPGR - 300
DRKADEDHYR EQQALNESSA KNGAASKRAF KQSPPAVPAL GAGVKKRRHG DEDTYYLQVR - 360
GRENFEILMK LKESLELMEL VPQPLVDSYR QQQQLLQRPS HLQPPSYGPV LSPMNKVHGG - 420
MNKLPSVNQL VGQPPPHSSA ATPNLGPVGP GMLNNHGHAV PANGEMSSSH SAQSMVSGSH - 480
CTPPPPYHAD PSLVSFLTGL GCPNCIEYFT SQGLQSIYHL QNLTIEDLGA LKIPEQYRMT - 540
IWRGLQDLKQ GHDYSTAQQL LRSSNAATIS IGGSGELQRQ RVMEAVHFRV RHTITIPNRG - 600
GPGGGPDEWA DFGFDLPDCK ARKQPIKEEF TEAEIH
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| Functional narrative |
Participates in the apoptotic response to DNA damage. Isoforms containing the transactivation domain are pro-apoptotic, isoforms lacking the domain are anti-apoptotic and block the function of p53 and transactivating p73 isoforms. May be a tumor suppressor protein.
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| Map of ordered and disordered regions |
Note: 'Mouse' over a region to see the start and stop residues. Click on a region to see detailed information.
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| Region 1 | | Type: | Disordered | | Name: | | | Location: | 487 - 491 | | Length: | 5 | | Region sequence: |
YHADP | | Modification type: | | | PDB: | 1DXS:A | | Structural/functional type: | | | Functional classes: | | | Functional subclasses: | | Detection methods:
| References:
- Wang WK, Bycroft M, Foster NW, Buckle AM, Fersht AR, Chen YW. "Structure of the C-terminal sterile alpha-motif (SAM) domain of human p73 alpha." Acta Crystallogr D Biol Crystallogr. 2001; 57(Pt 4): 545-51. PubMed: 11264583
| Comments:
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| Region 2 | | Type: | Disordered | | Name: | | | Location: | 549 - 564 | | Length: | 16 | | Region sequence: |
KQGHDYSTAQQLLRSS | | Modification type: | | | PDB: | 1DXS:A | | Structural/functional type: | | | Functional classes: | | | Functional subclasses: | | Detection methods:
| References:
- Wang WK, Bycroft M, Foster NW, Buckle AM, Fersht AR, Chen YW. "Structure of the C-terminal sterile alpha-motif (SAM) domain of human p73 alpha." Acta Crystallogr D Biol Crystallogr. 2001; 57(Pt 4): 545-51. PubMed: 11264583
| Comments:
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| Comments |
This disordered protein entry is based solely on missing electron density in the Protein Data Bank.
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| If you have any comments or wish to provide additional references to this protein or its disordered region(s), please click here to e-mail us. |
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