| General information | | DisProt: | DP00320 | | Name: | Plasminogen activator inhibitor 1 | | Synonym(s): | PAI1_HUMAN
PAI-1
PAI
Endothelial plasminogen activator inhibitor
| | First appeared in release: | Release 3.0 (02/17/2006) | | UniProt: | P05121 | | UniGene: | Hs.414795 | | SwissProt: | PAI1_HUMAN | | TrEMBL: | | | NCBI (GI): | 129576 | | Source organism: | Homo sapiens (Human) | | Sequence length: | 402 | | Percent disordered: | 6% | | Homologues: | |
| Native sequence |
10 20 30 40 50 60
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MQMSPALTCL VLGLALVFGE GSAVHHPPSY VAHLASDFGV RVFQQVAQAS KDRNVVFSPY - 60
GVASVLAMLQ LTTGGETQQQ IQAAMGFKID DKGMAPALRH LYKELMGPWN KDEISTTDAI - 120
FVQRDLKLVQ GFMPHFFRLF RSTVKQVDFS EVERARFIIN DWVKTHTKGM ISNLLGKGAV - 180
DQLTRLVLVN ALYFNGQWKT PFPDSSTHRR LFHKSDGSTV SVPMMAQTNK FNYTEFTTPD - 240
GHYYDILELP YHGDTLSMFI AAPYEKEVPL SALTNILSAQ LISHWKGNMT RLPRLLVLPK - 300
FSLETEVDLR KPLENLGMTD MFRQFQADFT SLSDQEPLHV AQALQKVKIE VNESGTVASS - 360
STAVIVSARM APEEIIMDRP FLFVVRHNPT GTVLFMGQVM EP
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| Functional narrative |
This inhibitor acts as 'bait' for tissue plasminogen activator, urokinase, and protein C. Its rapid interaction with TPA may function as a major control point in the regulation of fibrinolysis.
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| Map of ordered and disordered regions |
Note: 'Mouse' over a region to see the start and stop residues. Click on a region to see detailed information.
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| Region 1 | | Type: | Disordered | | Name: | | | Location: | 1 - 23 | | Length: | 23 | | Region sequence: |
MQMSPALTCLVLGLALVFGEGSA | | Modification type: | | | PDB: | 1C5G:A | | Structural/functional type: | | | Functional classes: | | | Functional subclasses: | | Detection methods:
| References:
- Tucker HM, Mottonen J, Goldsmith EJ, Gerard RD. "Engineering of plasminogen activator inhibitor-1 to reduce the rate of latency transition." Nat Struct Biol. 1995; 2(6): 442-5. PubMed: 7664104
| Comments:
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| Comments |
This disordered protein entry is based solely on missing electron density in the Protein Data Bank.
Additional UniGene ID: Hs.713079
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