Annotation for this protein is in progress - please check future releases for more complete information


DP00321: Protein-arginine deiminase type-4FASTA viewXML view

General information
DisProt:DP00321
Name:Protein-arginine deiminase type-4
Synonym(s):PADI4_HUMAN
EC 3.5.3.15
Protein-arginine deiminase type IV
Peptidylarginine deiminase IV
HL-60 PAD
First appeared in release:Release 3.0 (02/17/2006)
UniProt:Q9UM07
UniGene:Hs.522969
SwissProt: PADI4_HUMAN
TrEMBL:  
NCBI (GI): 12230488
Source organism:Homo sapiens (Human)
Sequence length:663
Percent disordered:19%
Homologues: 


Native sequence

        10         20         30         40         50         60
         |          |          |          |          |          |
MAQGTLIRVT PEQPTHAVCV LGTLTQLDIC SSAPEDCTSF SINASPGVVV DIAHSPPAKK - 60
KSTGSSTWPL DPGVEVTLTM KAASGSTGDQ KVQISYYGPK TPPVKALLYL TAVEISLCAD - 120
ITRTGKVKPT RAVKDQRTWT WGPCGQGAIL LVNCDRDNLE SSAMDCEDDE VLDSEDLQDM - 180
SLMTLSTKTP KDFFTNHTLV LHVARSEMDK VRVFQATRGK LSSKCSVVLG PKWPSHYLMV - 240
PGGKHNMDFY VEALAFPDTD FPGLITLTIS LLDTSNLELP EAVVFQDSVV FRVAPWIMTP - 300
NTQPPQEVYA CSIFENEDFL KSVTTLAMKA KCKLTICPEE ENMDDQWMQD EMEIGYIQAP - 360
HKTLPVVFDS PRNRGLKEFP IKRVMGPDFG YVTRGPQTGG ISGLDSFGNL EVSPPVTVRG - 420
KEYPLGRILF GDSCYPSNDS RQMHQALQDF LSAQQVQAPV KLYSDWLSVG HVDEFLSFVP - 480
APDRKGFRLL LASPRSCYKL FQEQQNEGHG EALLFEGIKK KKQQKIKNIL SNKTLREHNS - 540
FVERCIDWNR ELLKRELGLA ESDIIDIPQL FKLKEFSKAE AFFPNMVNML VLGKHLGIPK - 600
PFGPVINGRC CLEEKVCSLL EPLGLQCTFI NDFFTYHIRH GEVHCGTNVR RKPFSFKWWN - 660
MVP



Functional narrative    

Catalyzes the citrullination/deimination of arginine residues of proteins. Citrullinates histone H3 at 'Arg-8' and/or 'Arg-17' and histone H4 at 'Arg-3', which prevents their methylation by CARM1 and HRMT1L2/PRMT1 and represses transcription. Citrullinates EP300/P300 at 'Arg-2142', which favors its interaction with NCOA2/GRIP1.

Region 1: 1-1 Region 2: 33-65 Region 3: 129-135 Region 4: 158-171 Region 5: 219-223 Region 6: 313-319 Region 7: 338-348 Region 8: 371-402 Region 9: 516-521 Region 10: 633-644

Map of ordered and disordered regions







Note: 'Mouse' over a region to see the start and stop residues. Click on a region to see detailed information.


Region 1
Type:Disordered
Name: 
Location:1 - 1
Length:1
Region sequence:

M

Modification type:  
PDB: 1WD8:A
Structural/functional type:  
Functional classes:  
Functional subclasses:  
Detection methods:
 
References:
  1. Arita K, Hashimoto H, Shimizu T, Nakashima K, Yamada M, Sato M. "Structural basis for Ca(2+)-induced activation of human PAD4." Nat Struct Mol Biol. 2004; 11(8): 777-83. PubMed: 15247907
Comments:
According to the PDB fle, this region had an additional 7 amino acid tag on the N-terminal end consisting of GPLGSPQ.


Region 2
Type:Disordered
Name: 
Location:33 - 65
Length:33
Region sequence:

APEDCTSFSINASPGVVVDIAHSPPAKKKSTGS

Modification type:  
PDB: 1WD8:A
Structural/functional type:  
Functional classes:  
Functional subclasses:  
Detection methods:
 
References:
  1. Arita K, Hashimoto H, Shimizu T, Nakashima K, Yamada M, Sato M. "Structural basis for Ca(2+)-induced activation of human PAD4." Nat Struct Mol Biol. 2004; 11(8): 777-83. PubMed: 15247907
Comments:
 



Region 3
Type:Disordered
Name: 
Location:129 - 135
Length:7
Region sequence:

PTRAVKD

Modification type:  
PDB: 1WD8:A
Structural/functional type:  
Functional classes:  
Functional subclasses:  
Detection methods:
 
References:
  1. Arita K, Hashimoto H, Shimizu T, Nakashima K, Yamada M, Sato M. "Structural basis for Ca(2+)-induced activation of human PAD4." Nat Struct Mol Biol. 2004; 11(8): 777-83. PubMed: 15247907
Comments:
 



Region 4
Type:Disordered
Name: 
Location:158 - 171
Length:14
Region sequence:

NLESSAMDCEDDEV

Modification type:  
PDB: 1WD8:A
Structural/functional type:  
Functional classes:  
Functional subclasses:  
Detection methods:
 
References:
  1. Arita K, Hashimoto H, Shimizu T, Nakashima K, Yamada M, Sato M. "Structural basis for Ca(2+)-induced activation of human PAD4." Nat Struct Mol Biol. 2004; 11(8): 777-83. PubMed: 15247907
Comments:
 



Region 5
Type:Disordered
Name: 
Location:219 - 223
Length:5
Region sequence:

GKLSS

Modification type:  
PDB: 1WD8:A
Structural/functional type:  
Functional classes:  
Functional subclasses:  
Detection methods:
 
References:
  1. Arita K, Hashimoto H, Shimizu T, Nakashima K, Yamada M, Sato M. "Structural basis for Ca(2+)-induced activation of human PAD4." Nat Struct Mol Biol. 2004; 11(8): 777-83. PubMed: 15247907
Comments:
 



Region 6
Type:Disordered
Name: 
Location:313 - 319
Length:7
Region sequence:

IFENEDF

Modification type:  
PDB: 1WD8:A
Structural/functional type:  
Functional classes:  
Functional subclasses:  
Detection methods:
 
References:
  1. Arita K, Hashimoto H, Shimizu T, Nakashima K, Yamada M, Sato M. "Structural basis for Ca(2+)-induced activation of human PAD4." Nat Struct Mol Biol. 2004; 11(8): 777-83. PubMed: 15247907
Comments:
 



Region 7
Type:Disordered
Name: 
Location:338 - 348
Length:11
Region sequence:

PEEENMDDQWM

Modification type:  
PDB: 1WD8:A
Structural/functional type:  
Functional classes:  
Functional subclasses:  
Detection methods:
 
References:
  1. Arita K, Hashimoto H, Shimizu T, Nakashima K, Yamada M, Sato M. "Structural basis for Ca(2+)-induced activation of human PAD4." Nat Struct Mol Biol. 2004; 11(8): 777-83. PubMed: 15247907
Comments:
 



Region 8
Type:Disordered
Name: 
Location:371 - 402
Length:32
Region sequence:

PRNRGLKEFPIKRVMGPDFGYVTRGPQTGGIS

Modification type:  
PDB: 1WD8:A
Structural/functional type:  
Functional classes:  
Functional subclasses:  
Detection methods:
 
References:
  1. Arita K, Hashimoto H, Shimizu T, Nakashima K, Yamada M, Sato M. "Structural basis for Ca(2+)-induced activation of human PAD4." Nat Struct Mol Biol. 2004; 11(8): 777-83. PubMed: 15247907
Comments:
 



Region 9
Type:Disordered
Name: 
Location:516 - 521
Length:6
Region sequence:

EGIKKK

Modification type:  
PDB: 1WD8:A
Structural/functional type:  
Functional classes:  
Functional subclasses:  
Detection methods:
 
References:
  1. Arita K, Hashimoto H, Shimizu T, Nakashima K, Yamada M, Sato M. "Structural basis for Ca(2+)-induced activation of human PAD4." Nat Struct Mol Biol. 2004; 11(8): 777-83. PubMed: 15247907
Comments:
 



Region 10
Type:Disordered
Name: 
Location:633 - 644
Length:12
Region sequence:

FFTYHIRHGEVH

Modification type:  
PDB: 1WD8:A
Structural/functional type:  
Functional classes:  
Functional subclasses:  
Detection methods:
 
References:
  1. Arita K, Hashimoto H, Shimizu T, Nakashima K, Yamada M, Sato M. "Structural basis for Ca(2+)-induced activation of human PAD4." Nat Struct Mol Biol. 2004; 11(8): 777-83. PubMed: 15247907
Comments:
 



Comments


This disordered protein entry is based solely on missing electron density in the Protein Data Bank.


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