| General information | | DisProt: | DP00322 | | Name: | Proto-oncogene serine/threonine-protein kinase Pim-1 [Isoform 2] | | Synonym(s): | PIM1_HUMAN
EC=2.7.11.1
| | First appeared in release: | Release 3.0 (02/17/2006) | | UniProt: | P11309-2 | | UniGene: | Hs.81170 | | SwissProt: | PIM1_HUMAN | | TrEMBL: | | | NCBI (GI): | 83305339 | | Source organism: | Homo sapiens (Human) | | Sequence length: | 313 | | Percent disordered: | 7% | | Homologues: | |
| Native sequence |
10 20 30 40 50 60
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MLLSKINSLA HLRAAPCNDL HATKLAPGKE KEPLESQYQV GPLLGSGGFG SVYSGIRVSD - 60
NLPVAIKHVE KDRISDWGEL PNGTRVPMEV VLLKKVSSGF SGVIRLLDWF ERPDSFVLIL - 120
ERPEPVQDLF DFITERGALQ EELARSFFWQ VLEAVRHCHN CGVLHRDIKD ENILIDLNRG - 180
ELKLIDFGSG ALLKDTVYTD FDGTRVYSPP EWIRYHRYHG RSAAVWSLGI LLYDMVCGDI - 240
PFEHDEEIIR GQVFFRQRVS SECQHLIRWC LALRPSDRPT FEEIQNHPWM QDVLLPQETA - 300
EIHLHSLSPG PSK
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| Functional narrative |
May affect the structure or silencing of chromatin by phosphorylating HP1 gamma/CBX3. Isoform 2 promotes the G1/S transition of the cell cycle via up-regulation of CDK2 activity and phosphorylation of CDKN1B, resulting in enhanced nuclear export and proteasome-dependent degradation of CDKN1B. Isoform 2 also represses CDKN1B transcription by phosphorylating and inactivating the transcription factor FOXO3. Plays a role in signal transduction in blood cells. Contributes to both cell proliferation and survival and thus provides a selective advantage in tumorigenesis.
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| Map of ordered and disordered regions |
Note: 'Mouse' over a region to see the start and stop residues. Click on a region to see detailed information.
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| Region 1 | | Type: | Disordered | | Name: | | | Location: | 14 - 31 | | Length: | 18 | | Region sequence: |
AAPCNDLHATKLAPGKEK | | Modification type: | | | PDB: | 1XQZ:A | | Structural/functional type: | | | Functional classes: | | | Functional subclasses: | | Detection methods:
| References:
- Qian KC, Wang L, Hickey ER, Studts J, Barringer K, Peng C, Kronkaitis A, Li J, White A, Mische S, Farmer B. "Structural basis of constitutive activity and a unique nucleotide binding mode of human Pim-1 kinase." J Biol Chem. 2005; 280(7): 6130-7. PubMed: 15525646
| Comments:
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| Region 2 | | Type: | Disordered | | Name: | | | Location: | 309 - 313 | | Length: | 5 | | Region sequence: |
PGPSK | | Modification type: | | | PDB: | 1XQZ:A | | Structural/functional type: | | | Functional classes: | | | Functional subclasses: | | Detection methods:
| References:
- Qian KC, Wang L, Hickey ER, Studts J, Barringer K, Peng C, Kronkaitis A, Li J, White A, Mische S, Farmer B. "Structural basis of constitutive activity and a unique nucleotide binding mode of human Pim-1 kinase." J Biol Chem. 2005; 280(7): 6130-7. PubMed: 15525646
| Comments:
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| Comments |
This disordered protein entry is based solely on missing electron density in the Protein Data Bank.
The Swiss Prot sequence is the full length unprossed precursor. The experiments in the PDB file used the 313 amino acid processed protein.
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