| General information | | DisProt: | DP00324 | | Name: | Heterogeneous nuclear ribonucleoprotein A1 [Isoform A1-B] | | Synonym(s): | ROA1_HUMAN
hnRNP core protein A1
Helix-destabilizing protein
Single-strand binding protein
| | First appeared in release: | Release 3.0 (02/17/2006) | | UniProt: | P09651-1 | | UniGene: | Hs.546261 | | SwissProt: | ROA1_HUMAN | | TrEMBL: | | | NCBI (GI): | 133254 | | Source organism: | Homo sapiens (Human) | | Sequence length: | 371 | | Percent disordered: | 9% | | Homologues: | |
| Native sequence |
10 20 30 40 50 60
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SKSESPKEPE QLRKLFIGGL SFETTDESLR SHFEQWGTLT DCVVMRDPNT KRSRGFGFVT - 60
YATVEEVDAA MNARPHKVDG RVVEPKRAVS REDSQRPGAH LTVKKIFVGG IKEDTEEHHL - 120
RDYFEQYGKI EVIEIMTDRG SGKKRGFAFV TFDDHDSVDK IVIQKYHTVN GHNCEVRKAL - 180
SKQEMASASS SQRGRSGSGN FGGGRGGGFG GNDNFGRGGN FSGRGGFGGS RGGGGYGGSG - 240
DGYNGFGNDG GYGGGGPGYS GGSRGYGSGG QGYGNQGSGY GGSGSYDSYN NGGGRGFGGG - 300
SGSNFGGGGS YNDFGNYNNQ SSNFGPMKGG NFGGRSSGPY GGGGQYFAKP RNQGGYGGSS - 360
SSSSYGSGRR F
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| Functional narrative |
Involved in the packaging of pre-mRNA into hnRNP particles, transport of poly(A) mRNA from the nucleus to the cytoplasm and may modulate splice site selection. May play a role in HCV RNA replication.
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| Map of ordered and disordered regions |
Note: 'Mouse' over a region to see the start and stop residues. Click on a region to see detailed information.
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| Region 1 | | Type: | Disordered | | Name: | | | Location: | 1 - 6 | | Length: | 6 | | Region sequence: |
SKSESP | | Modification type: | | | PDB: | 1L3K:A | | Structural/functional type: | | | Functional classes: | | | Functional subclasses: | | Detection methods:
| References:
- Vitali J, Ding J, Jiang J, Zhang Y, Krainer AR, Xu RM. "Correlated alternative side chain conformations in the RNA-recognition motif of heterogeneous nuclear ribonucleoprotein A1." Nucleic Acids Res. 2002; 30(7): 1531-8. PubMed: 11917013
| Comments:
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| Region 2 | | Type: | Disordered | | Name: | | | Location: | 91 - 101 | | Length: | 11 | | Region sequence: |
REDSQRPGAHL | | Modification type: | | | PDB: | 1L3K:A | | Structural/functional type: | | | Functional classes: | | | Functional subclasses: | | Detection methods:
| References:
- Vitali J, Ding J, Jiang J, Zhang Y, Krainer AR, Xu RM. "Correlated alternative side chain conformations in the RNA-recognition motif of heterogeneous nuclear ribonucleoprotein A1." Nucleic Acids Res. 2002; 30(7): 1531-8. PubMed: 11917013
| Comments:
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| Region 3 | | Type: | Disordered | | Name: | | | Location: | 181 - 195 | | Length: | 15 | | Region sequence: |
SKQEMASASSSQRGR | | Modification type: | | | PDB: | 1L3K:A | | Structural/functional type: | | | Functional classes: | | | Functional subclasses: | | Detection methods:
| References:
- Vitali J, Ding J, Jiang J, Zhang Y, Krainer AR, Xu RM. "Correlated alternative side chain conformations in the RNA-recognition motif of heterogeneous nuclear ribonucleoprotein A1." Nucleic Acids Res. 2002; 30(7): 1531-8. PubMed: 11917013
| Comments:
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| Comments |
This disordered protein entry is based solely on missing electron density in the Protein Data Bank.
Additional UniGene ID: Hs.655424
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