| General information | | DisProt: | DP00325 | | Name: | Protein phosphatase 1 regulatory subunit 1A | | Synonym(s): | PPR1A_RABIT
Protein phosphatase inhibitor 1
IPP-1
I-1
| | First appeared in release: | Release 3.0 (02/17/2006) | | UniProt: | P01099 | | UniGene: | | | SwissProt: | PPR1A_RABIT | | TrEMBL: | | | NCBI (GI): | 124834 | | Source organism: | Oryctolagus cuniculus (Rabbit) | | Sequence length: | 166 | | Percent disordered: | 100% | | Homologues: | |
| Native sequence |
10 20 30 40 50 60
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MEQDNSPRKI QFTVPLLEPH LDPEAAEQIR RRRPTPATLV LTSDQSSPEV DEDRIPNPLL - 60
KPSLAMSPRQ RKKMTRTTPT MKELQMMVEH HLGQQEQGEE PEGAAEGTGA QESQPPGTPG - 120
TGAESRLGPS ATAQKPAQPS PRAQERRGEE PSTAKTSQDS QGASAV
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| Functional narrative |
Inhibitor of protein-phosphatase 1. This protein may be important in hormonal control of glycogen metabolism. Hormones that elevate intracellular cAMP increase I-1 activity in many tissues. I-1 activation may impose cAMP control over proteins that are not directly phosphorylated by PKA. Following a rise in intracellular calcium, I-1 is inactivated by calcineurin (or PP2B). Does not inhibit type-2 phosphatases.
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| Map of ordered and disordered regions |
Note: 'Mouse' over a region to see the start and stop residues. Click on a region to see detailed information.
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| Region 1 | | Type: | Disordered | | Name: | | | Location: | 1 - 166 | | Length: | 166 | | Region sequence: |
MEQDNSPRKIQFTVPLLEPHLDPEAAEQIRRRRPTPATLVLTSDQSSPEVDEDRIPNPLL
KPSLAMSPRQRKKMTRTTPTMKELQMMVEHHLGQQEQGEEPEGAAEGTGAQESQPPGTPG
TGAESRLGPSATAQKPAQPSPRAQERRGEEPSTAKTSQDSQGASAV | | Modification type: | | | PDB: | | | Structural/functional type: | | | Functional classes: | | | Functional subclasses: | | Detection methods:
- Size exclusion/gel filtration chromatography (pH: 8.3; )
- Stability at thermal extremes (373 K; )
| References:
- Nimmo GA, Cohen P. "The regulation of glycogen metabolism. Purification and characterisation of protein phosphatase inhibitor-1 from rabbit skeletal muscle." Eur J Biochem. 1978; 87(2): 341-51. PubMed: 208844
| Comments:
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| References |
- Elbrecht A, DiRenzo J, Smith RG, Shenolikar S. "Molecular cloning of protein phosphatase inhibitor-1 and its expression in rat and rabbit tissues." J Biol Chem. 1990; 265(23): 13415-8. PubMed: 1696252
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