Annotation for this protein is in progress - please check future releases for more complete information


DP00343: Nuclear receptor coactivator 3 [Isoform 3, variant]FASTA viewXML view

General information
DisProt:DP00343
Name:Nuclear receptor coactivator 3 [Isoform 3, variant]
Synonym(s):NCOA3_HUMAN
NCoA-3
EC=2.3.1.48
Thyroid hormone receptor activator molecule 1
TRAM-1
ACTR
Receptor-associated coactivator 3
RAC-3
Amplified in breast cancer-1 protein
AIB-1
Steroid receptor coactivator protein 3
SRC-3
CBP-interacting protein
pCIP
First appeared in release:Release 3.0 (02/17/2006)
UniProt:Q9Y6Q9-3
UniGene:Hs.592142
SwissProt: NCOA3_HUMAN
TrEMBL:  
NCBI (GI): 2707770
Source organism:Homo sapiens (Human)
Sequence length:1412
Percent disordered:5%
Homologues: 


Native sequence

        10         20         30         40         50         60
         |          |          |          |          |          |
MSGLGENLDP LASDSRKRKL PCDTPGQGLT CSGEKRRREQ ESKYIEELAE LISANLSDID - 60
NFNVKPDKCA ILKETVRQIR QIKEQGKTIS NDDDVQKADV SSTGQGVIDK DSLGPLLLQA - 120
LDGFLFVVNR DGNIVFVSEN VTQYLQYKQE DLVNTSVYNI LHEEDRKDFL KNLPKSTVNG - 180
VSWTNETQRQ KSHTFNCRML MKTPHDILED INASPEMRQR YETMQCFALS QPRAMMEEGE - 240
DLQSCMICVA RRITTGERTF PSNPESFITR HDLSGKVVNI DTNSLRSSMR PGFEDIIRRC - 300
IQRFFSLNDG QSWSQKRHYQ EVTSDGIFSP TAYLNGHAET PVYRFSLADG TIVTAQTKSK - 360
LFRNPVTNDR HGFVSTHFLQ REQNGYRPNP NPVGQGIRPP MAGCNSSVGG MSMSPNQGLQ - 420
MPSSRAYGLA DPSTTGQMSG ARYGGSSNIA SLTPGPGMQS PSSYQNNNYR LNMSSPPHGS - 480
PGLAPNQQNI MISPRNRGSP KIASHQFSPV AGVHSPMASS GNTGNHSFSS SSLSALQAIS - 540
EGVGTSLLST LSSPGPKLDN SPNMNITQPS KVSNQDSKSP LGFYCDQNPV ESSMCQSNSR - 600
DHLSDKESKE SSVEGAENQR GPLESKGHKK LLQLLTCSSD DRGHSSLTNS PLDSSCKESS - 660
VSVTSPSGVS SSTSGGVSST SNMHGSLLQE KHRILHKLLQ NGNSPAEVAK ITAEATGKDT - 720
SSITSCGDGN VVKQEQLSPK KKENNALLRY LLDRDDPSDA LSKELQPQVE GVDNKMSQCT - 780
SSTIPSSSQE KDPKIKTETS EEGSGDLDNL DAILGDLTSS DFYNNSISSN GSHLGTKQQV - 840
FQGTNSLGLK SSQSVQSIRP PYNRAVSLDS PVSVGSSPPV KNISAFPMLP KQPMLGGNPR - 900
MMDSQENYGS SMGDWGLPNS KAGRMEPMNS NSMGRPGGDY NTSLPRPALG GSIPTLPLRS - 960
NSIPGARPVL QQQQQMLQMR PGEIPMGMGA NPYGQAAASN QLGSWPDGML SMEQVSHGTQ - 1020
NRPLLRNSLD DLVGPPSNLE GQSDERALLD QLHTLLSNTD ATGLEEIDRA LGIPELVNQG - 1080
QALEPKQDAF QGQEAAVMMD QKAGLYGQTY PAQGPPMQGG FHLQGQSPSF NSMMNQMNQQ - 1140
GNFPLQGMHP RANIMRPRTN TPKQLRMQLQ QRLQGQQFLN QSRQALELKM ENPTAGGAAV - 1200
MRPMMQPQQG FLNAQMVAQR SRELLSHHFR QQRVAMMMQQ QQQQQQQQQQ QQQQQQQQQQ - 1260
QQQQTQAFSP PPNVTASPSM DGLLAGPTMP QAPPQQFPYQ PNYGMGQQPD PAFGRVSSPP - 1320
NAMMSSRMGP SQNPMMQHPQ AASIYQSSEM KGWPSGNLAR NSSFSQQQFA HQGNPAVYSM - 1380
VHMNGSSGHM GQMNMNPMPM SGMPMGPDQK YC



Functional narrative    

Nuclear receptor coactivator that directly binds nuclear receptors and stimulates the transcriptional activities in a hormone-dependent fashion. Plays a central role in creating a multisubunit coactivator complex, which probably acts via remodeling of chromatin. Involved in the coactivation of different nuclear receptors, such as for steroids (GR and ER), retinoids (RARs and RXRs), thyroid hormone (TRs), vitamin D3 (VDR) and prostanoids (PPARs). Displays histone acetyltransferase activity. Also involved in the coactivation of the NF-kappa-B pathway via its interaction with the NFKB1 subunit.

Region 2: 1018-1045 Region 1: 1018-1088 Region 3: 1084-1088

Map of ordered and disordered regions







Note: 'Mouse' over a region to see the start and stop residues. Click on a region to see detailed information.


Region 1
Type:Disordered
Name:CBP binding domain
Location:1018 - 1088
Length:71
Region sequence:

GTQNRPLLRNSLDDLVGPPSNLEGQSDERALLDQLHTLLSNTDATGLEEIDRALGIPELV
NQGQALEPKQD

Modification type: Engineered
Fragment
PDB:  
Structural/functional type: Function arises via a disorder to order transition
Functional classes: Molecular assembly
Functional subclasses: Protein-protein binding
Detection methods:
  1. Nuclear magnetic resonance (NMR) (304 K; d11-Tris (pH 6.6) 10 mM; NaCl 50 mM)
References:
  1. Demarest SJ, Martinez-Yamout M, Chung J, Chen H, Xu W, Dyson HJ, Evans RM, Wright PE. "Mutual synergistic folding in recruitment of CBP/p300 by p160 nuclear receptor coactivators." Nature. 2002; 415(6871): 549-53. PubMed: 11823864
Comments:
 



Region 2
Type:Disordered
Name: 
Location:1018 - 1045
Length:28
Region sequence:

GTQNRPLLRNSLDDLVGPPSNLEGQSDE

Modification type: Complex
Engineered
Fragment
PDB:  
Structural/functional type: Relationship to function unknown
Functional classes: Unknown
Functional subclasses: Unknown
Detection methods:
  1. Nuclear magnetic resonance (NMR) (304 K; d11-Tris (pH 6.6) 10 mM; NaCl 50 mM)
References:
  1. Demarest SJ, Martinez-Yamout M, Chung J, Chen H, Xu W, Dyson HJ, Evans RM, Wright PE. "Mutual synergistic folding in recruitment of CBP/p300 by p160 nuclear receptor coactivators." Nature. 2002; 415(6871): 549-53. PubMed: 11823864
Comments:
 



Region 3
Type:Disordered
Name: 
Location:1084 - 1088
Length:5
Region sequence:

EPKQD

Modification type: Complex
Engineered
Fragment
PDB:  
Structural/functional type: Relationship to function unknown
Functional classes: Unknown
Functional subclasses: Unknown
Detection methods:
  1. Nuclear magnetic resonance (NMR) (304 K; d11-Tris (pH 6.6) 10 mM; NaCl 50 mM)
References:
  1. Demarest SJ, Martinez-Yamout M, Chung J, Chen H, Xu W, Dyson HJ, Evans RM, Wright PE. "Mutual synergistic folding in recruitment of CBP/p300 by p160 nuclear receptor coactivators." Nature. 2002; 415(6871): 549-53. PubMed: 11823864
Comments:
 



References

  1. Chen H, Lin RJ, Schiltz RL, Chakravarti D, Nash A, Nagy L, Privalsky ML, Nakatani Y, Evans RM. "Nuclear receptor coactivator ACTR is a novel histone acetyltransferase and forms a multimeric activation complex with P/CAF and CBP/p300." Cell. 1997; 90(3): 569-80. PubMed: 9267036



Comments


The sequence provided by Chen is a natural variant of isoform 3. Residues 1248 - 1250 (Gln-Gln) are missing.


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