Annotation for this protein is in progress - please check future releases for more complete information


DP00361: XO lethal protein 1 [Isoform b]FASTA viewXML view

General information
DisProt:DP00361
Name:XO lethal protein 1 [Isoform b]
Synonym(s):XOL1_CAEEL
XOL-1 protein
Early switch protein xol-1 2.2k splice form
First appeared in release:Release 1.1 (12/01/2003)
UniProt:Q23229-1
UniGene:Cel.19778
SwissProt: XOL1_CAEEL
TrEMBL:  
NCBI (GI): 74966653
Source organism:Caenorhabditis elegans
Sequence length:417
Percent disordered:6%
Homologues: 


Native sequence

        10         20         30         40         50         60
         |          |          |          |          |          |
MQVEANSERR VKILGIDRSE NSPVLTYMET EDDPNFRNSK LAAAPHTVHM MDSGFLAINR - 60
QCLVKGKAIL AREPKSSNEH MIDDLPKHAH DQHTLSILRD FIDQLKLHNV YEINFYDPLD - 120
SSGKLAVIPM LIALWKCMLA SETDICDQEV LKSIMNSVIA KFELQIPCKN AVIDATLSGS - 180
REEVHIIAED GSLENSNGTT EHFNKKHDLV FVKTDLHPED FTPQMFPSQA KAKLLRDAFN - 240
NEEDEDTFPD ILVPAYMTAH SKNRVRQEDY TCLEVEFDSQ VALEKLMNEH EQVEGFEVQQ - 300
GGILVALKKD SFFDDELIEK IAIAIATESR QSVSSVSFDL LKLGPGASLV TLANSRRFEP - 360
ECRVVLQIEV KPVSPGETSS EGISDEHHYE EYDEDDIMEE EEAPSARQDD TYDEDEE



Functional narrative    

Acts as a primary sex-determining factor that promotes sexual differentiation. Absolutely required for proper sexual differentiation and male viability. High expression during gastrulation triggers male development, while low expression at that time triggers hermaphrodite development. Although related to GHMP kinase, its mode of action remains unclear.

Region 1: 1-7 Region 2: 29-38 Region 3: 190-195

Map of ordered and disordered regions







Note: 'Mouse' over a region to see the start and stop residues. Click on a region to see detailed information.


Region 1
Type:Disordered
Name: 
Location:1 - 7
Length:7
Region sequence:

MQVEANS

Modification type: Engineered
Fragment
Mutant
PDB:  
Structural/functional type: Relationship to function unknown
Functional classes: Unknown
Functional subclasses: Unknown
Detection methods:
  1. X-ray crystallography (277 K; HEPES (pH 7.8) 0.1 M; MgCl2 0.2 M; MPD (>5%); PEG400 17.5 %)
References:
  1. Luz JG, Hassig CA, Pickle C, Godzik A, Meyer BJ, Wilson IA. "XOL-1, primary determinant of sexual fate in C. elegans, is a GHMP kinase family member and a structural prototype for a class of developmental regulators." Genes Dev. 2003; 17(8): 977-90. PubMed: 12672694
Comments:
 



Region 2
Type:Disordered
Name: 
Location:29 - 38
Length:10
Region sequence:

ETEDDPNFRN

Modification type: Engineered
Fragment
Mutant
PDB:  
Structural/functional type: Relationship to function unknown
Functional classes: Unknown
Functional subclasses: Unknown
Detection methods:
  1. X-ray crystallography (277 K; HEPES (pH 7.8) 0.1 M; MgCl2 0.2 M; MPD (>5%); PEG400 17.5 %)
References:
  1. Luz JG, Hassig CA, Pickle C, Godzik A, Meyer BJ, Wilson IA. "XOL-1, primary determinant of sexual fate in C. elegans, is a GHMP kinase family member and a structural prototype for a class of developmental regulators." Genes Dev. 2003; 17(8): 977-90. PubMed: 12672694
Comments:
 



Region 3
Type:Disordered
Name: 
Location:190 - 195
Length:6
Region sequence:

DGSLEN

Modification type: Engineered
Fragment
Mutant
PDB:  
Structural/functional type: Relationship to function unknown
Functional classes: Unknown
Functional subclasses: Unknown
Detection methods:
  1. X-ray crystallography (277 K; HEPES (pH 7.8) 0.1 M; MgCl2 0.2 M; MPD (>5%); PEG400 17.5 %)
References:
  1. Luz JG, Hassig CA, Pickle C, Godzik A, Meyer BJ, Wilson IA. "XOL-1, primary determinant of sexual fate in C. elegans, is a GHMP kinase family member and a structural prototype for a class of developmental regulators." Genes Dev. 2003; 17(8): 977-90. PubMed: 12672694
Comments:
Electron density was not visible for residues 190-195 in monomer 1, and residues 190-194 in monomer 2.

If you have any comments or wish to provide additional references to this protein or its disordered region(s), please click here to e-mail us.


Disprot-footer
Contact us