Annotation for this protein is in progress - please check future releases for more complete information


DP00362: Neurofilament medium polypeptideFASTA viewXML view

General information
DisProt:DP00362
Name:Neurofilament medium polypeptide
Synonym(s):NFM_MOUSE
NF-M
Neurofilament triplet M protein
160 kDa neurofilament protein
Neurofilament 3
First appeared in release:Release 1.0 (08/01/2003)
UniProt:P08553
UniGene:Mm.242832
SwissProt: NFM_MOUSE
TrEMBL:  
NCBI (GI): 146345468
Source organism:Mus musculus (Mouse)
Sequence length:849
Percent disordered:52%
Homologues: 


Native sequence

        10         20         30         40         50         60
         |          |          |          |          |          |
MSYTLDSLGN PSAYRRVPTE TRSSFSRVSG SPSSGFRSQS WSRGSPSTVS SSYTRSAVAP - 60
RLAYSSAMLS SAESSLDFSQ SSSLLNGGSG GDYKLSRSNE KEQLQGLNDR FAGYIEKVHY - 120
LEQQNKEIEA EIQALRQKQA SHAQLGDAYD QEIRELRATL EMVNHEKAQV QLDSDHLEED - 180
IHRLKERFEE EARLRDDTEA AIRALRKDIE ESSMVKVELD KKVQSLQDEV AFLRRNHEEE - 240
VADLLAQIQA SHITVERKDY LKTDISTALK EIRSQLECHS DQNMHQAEEW FKCRYAKLTE - 300
AAEQNKEAIR SAKEEIAEYR RQLQSKSIEL ESVRGTKESL ERQLSDIEER HNHDLSSYQD - 360
TIQQLENELR GTKWEMARHL REYQDLLNVK MALDIEIAAY RKLLEGEETR FSTFSGSITG - 420
PLYTHRQPSV TISSKIQKTK VEAPKLKVQH KFVEEIIEET KVEDEKSEME ETLTAIAEEL - 480
AASAKEEKEE AEEKEEEPEA EKSPVKSPEA KEEEEEGEKE EEEEGQEEEE EEDEGVKSDQ - 540
AEEGGSEKEG SSEKDEGEQE EEEGETEAEG EGEEAEAKEE KKIEGKVEEV AVKEEIKVEK - 600
PEKAKSPMPK SPVEEVKPKP EAKAGKGEQK EEEKVEEEKK EVTKESPKEE KVEKKEEKPK - 660
DVADKKKAES PVKEKAVEEV ITISKSVKVS LEKDTKEEKP QPQEKVKEKA EEEGGSEEEG - 720
SDRSPQESKK EDIAINGEVE GKEEEEQETQ EKGSGREEEK GVVTNGLDVS PAEEKKGEDS - 780
SDDKVVVTKK VEKITSEGGD GATKYITKSV TVTQKVEEHE ETFEEKLVST KKVEKVTSHA - 840
IVKEVTQGD



Functional narrative    

Neurofilaments usually contain three intermediate filament proteins: L, M, and H which are involved in the maintenance of neuronal caliber.

Region 1: 411-848

Map of ordered and disordered regions







Note: 'Mouse' over a region to see the start and stop residues. Click on a region to see detailed information.


Region 1
Type:Disordered
Name: 
Location:411 - 848
Length:438
Region sequence:

STFSGSITGPLYTHRQPSVTISSKIQKTKVEAPKLKVQHKFVEEIIEETKVEDEKSEMEE
TLTAIAEELAASAKEEKEEAEEKEEEPEAEKSPVKSPEAKEEEEEGEKEEEEEGQEEEEE
EDEGVKSDQAEEGGSEKEGSSEKDEGEQEEEEGETEAEGEGEEAEAKEEKKIEGKVEEVA
VKEEIKVEKPEKAKSPMPKSPVEEVKPKPEAKAGKGEQKEEEKVEEEKKEVTKESPKEEK
VEKKEEKPKDVADKKKAESPVKEKAVEEVITISKSVKVSLEKDTKEEKPQPQEKVKEKAE
EEGGSEEEGSDRSPQESKKEDIAINGEVEGKEEEEQETQEKGSGREEEKGVVTNGLDVSP
AEEKKGEDSSDDKVVVTKKVEKITSEGGDGATKYITKSVTVTQKVEEHEETFEEKLVSTK
KVEKVTSHAIVKEVTQGD

Modification type:  
PDB:  
Structural/functional type:  
Functional classes:  
Functional subclasses:  
Detection methods:
 
References:
There are no documents referencing this region.
Comments:
 



Comments


Additional UniGene ID: Mm.390700


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