| General information | | DisProt: | DP00364 | | Name: | GTP-binding protein Rheb | | Synonym(s): | RHEB_HUMAN
Ras homolog enriched in brain
| | First appeared in release: | Release 3.0 (02/17/2006) | | UniProt: | Q15382 | | UniGene: | Hs.283521 | | SwissProt: | RHEB_HUMAN | | TrEMBL: | | | NCBI (GI): | 6919957 | | Source organism: | Homo sapiens (Human) | | Sequence length: | 184 | | Percent disordered: | 5% | | Homologues: | |
| Native sequence |
10 20 30 40 50 60
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MPQSKSRKIA ILGYRSVGKS SLTIQFVEGQ FVDSYDPTIE NTFTKLITVN GQEYHLQLVD - 60
TAGQDEYSIF PQTYSIDING YILVYSVTSI KSFEVIKVIH GKLLDMVGKV QIPIMLVGNK - 120
KDLHMERVIS YEEGKALAES WNAAFLESSA KENQTAVDVF RRIILEAEKM DGAASQGKSS - 180
CSVM
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| Functional narrative |
Stimulates the phosphorylation of S6K1 and EIF4EBP1 through activation of mTORC1 signaling. Activates the protein kinase activity of mTORC1. Has low intrinsic GTPase activity.
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| Map of ordered and disordered regions |
Note: 'Mouse' over a region to see the start and stop residues. Click on a region to see detailed information.
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| Region 1 | | Type: | Disordered | | Name: | switch I | | Location: | 33 - 41 | | Length: | 9 | | Region sequence: |
DSYDPTIEN | | Modification type: | Fragment
| | PDB: | | | Structural/functional type: | Function arises via a disorder to order transition
| | Functional classes: | Unknown
| | Functional subclasses: | Unknown
| Detection methods:
- X-ray crystallography
| References:
- Yu Y, Li S, Xu X, Li Y, Guan K, Arnold E, Ding J. "Structural basis for the unique biological function of small GTPase RHEB." J Biol Chem. 2005; 280(17): 17093-100. PubMed: 15728574
| Comments:
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| Comments |
Additional UniGene ID: Hs.568850, Hs.647068
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| If you have any comments or wish to provide additional references to this protein or its disordered region(s), please click here to e-mail us. |
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