| General information | | DisProt: | DP00372 | | Name: | Uncharacterized protein C8orf4 | | Synonym(s): | CH004_HUMAN
Thyroid cancer protein 1
TC-1
| | First appeared in release: | Release 3.0 (02/17/2006) | | UniProt: | Q9NR00 | | UniGene: | Hs.591849 | | SwissProt: | CH004_HUMAN | | TrEMBL: | | | NCBI (GI): | 71152395 | | Source organism: | Homo sapiens (Human) | | Sequence length: | 106 | | Percent disordered: | 100% | | Homologues: | |
| Native sequence |
10 20 30 40 50 60
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MKAKRSHQAI IMSTSLRVSP SIHGYHFDTA SRKKAVGNIF ENTDQESLER LFRNSGDKKA - 60
EERAKIIFAI DQDVEEKTRA LMALKKRTKD KLFQFLKLRK YSIKVH
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| Functional narrative |
The thyroid cancer 1 (TC-1) gene is overexpressed in thyroid cancer. The protein is monomeric and predominantly unstructured under conditions of physiologic salt and pH. It is possible that overexpression of TC-1 may be important in thyroid carcinogenesis. May decrease apoptosis.
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| Map of ordered and disordered regions |
Note: 'Mouse' over a region to see the start and stop residues. Click on a region to see detailed information.
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| Region 1 | | Type: | Disordered | | Name: | | | Location: | 1 - 106 | | Length: | 106 | | Region sequence: |
MKAKRSHQAIIMSTSLRVSPSIHGYHFDTASRKKAVGNIFENTDQESLERLFRNSGDKKA
EERAKIIFAIDQDVEEKTRALMALKKRTKDKLFQFLKLRKYSIKVH | | Modification type: | Native
| | PDB: | | | Structural/functional type: | Relationship to function unknown
| | Functional classes: | | | Functional subclasses: | | Detection methods:
- Circular dichroism (CD) spectroscopy, far-UV (pH: 6.8; Sodium acetate 10 mM)
- Nuclear magnetic resonance (NMR) (293 K; pH: 6.8; NaCl 150 mM; Sodium acetate 10 mM)
| References:
- Sunde M, McGrath KC, Young L, Matthews JM, Chua EL, Mackay JP, Death AK. "TC-1 is a novel tumorigenic and natively disordered protein associated with thyroid cancer." Cancer Res. 2004; 64(8): 2766-73. PubMed: 15087392
| Comments:
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| References |
- Gall C, Xu H, Brickenden A, Ai X, Choy WY. "The intrinsically disordered TC-1 interacts with Chibby via regions with high helical propensity." Protein Sci. 2007; 16(11): 2510-8. PubMed: 17905836
- Sunde M, McGrath KC, Young L, Matthews JM, Chua EL, Mackay JP, Death AK. "TC-1 is a novel tumorigenic and natively disordered protein associated with thyroid cancer." Cancer Res. 2004; 64(8): 2766-73. PubMed: 15087392
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