| General information | | DisProt: | DP00373 | | Name: | Penaeidin-3a | | Synonym(s): | P3-a
PEN3A_LITVA
Pen-3a
| | First appeared in release: | Release 3.0 (02/17/2006) | | UniProt: | P81058 | | UniGene: | | | SwissProt: | PEN3A_LITVA | | TrEMBL: | | | NCBI (GI): | 3024416 | | Source organism: | Litopenaeus vannamei (Whiteleg shrimp) (Penaeus vannamei) | | Sequence length: | 82 | | Percent disordered: | 34% | | Homologues: | |
| Native sequence |
10 20 30 40 50 60
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MRLVVCLVFL ASFALVCQGQ VYKGGYTRPI PRPPPFVRPL PGGPIGPYNG CPVSCRGISF - 60
SQARSCCSRL GRCCHVGKGY SG
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| Functional narrative |
Antibacterial activity against M.luteus and E.coli bacteria. Antifungal activity against N.crassa and F.oxysporum. Presents chitin-binding activity.
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| Map of ordered and disordered regions |
Note: 'Mouse' over a region to see the start and stop residues. Click on a region to see detailed information.
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| Region 1 | | Type: | Disordered | | Name: | | | Location: | 20 - 47 | | Length: | 28 | | Region sequence: |
QVYKGGYTRPIPRPPPFVRPLPGGPIGP | | Modification type: | Engineered
Fragment
| | PDB: | | | Structural/functional type: | | | Functional classes: | Unknown
| | Functional subclasses: | | Detection methods:
- Nuclear magnetic resonance (NMR) (pH: 3.9; D2O 99.98 %; D2O:H2O (95:5))
| References:
- Yang Y, Poncet J, Garnier J, Zatylny C, Bachere E, Aumelas A. "Solution structure of the recombinant penaeidin-3, a shrimp antimicrobial peptide." J Biol Chem. 2003; 278(38): 36859-67. PubMed: 12842879
| Comments:The SwissProt sequence contained an additional 19 amino acids at the N-terminus of this protein that were not used in the Yang et al. paper.
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| References |
- Derbyshire DJ, Basu BP, Serpell LC, Joo WS, Date T, Iwabuchi K, Doherty AJ. "Crystal structure of human 53BP1 BRCT domains bound to p53 tumour suppressor." EMBO J. 2002; 21(14): 3863-72. PubMed: 12110597
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