| General information | | DisProt: | DP00374 | | Name: | Diphtheria toxin repressor | | Synonym(s): | DTXR_CORDI
Iron-dependent diphtheria tox regulatory element
Tox regulatory factor
DtxR
| | First appeared in release: | Release 3.0 (02/17/2006) | | UniProt: | P33120 | | UniGene: | | | SwissProt: | DTXR_CORDI | | TrEMBL: | | | NCBI (GI): | 144976 | | Source organism: | Corynebacterium diphtheriae (strain PW8) | | Sequence length: | 226 | | Percent disordered: | 8% | | Homologues: | |
| Native sequence |
10 20 30 40 50 60
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MKDLVDTTEM YLRTIYELEE EGVTPLRARI AERLEQSGPT VSQTVARMER DGLVVVASDR - 60
SLQMTPTGRT LATAVMRKHR LAERLLTDII GLDINKVHDE ACRWEHVMSD EVERRLVKVL - 120
KDVSRSPFGN PIPGLDELGV GNSDAAAPGT RVIDAATSMP RKVRIVQINE IFQVETDQFT - 180
QLLDADIRVG SEVEIVDRDG HITLSHNGKD VELLDDLAHT IRIEEL
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| Functional narrative |
Iron-binding repressor of the dipheteria toxin gene expression. May serve as a global regulator of gene expression. Represses ripA under iron excess.
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| Map of ordered and disordered regions |
Note: 'Mouse' over a region to see the start and stop residues. Click on a region to see detailed information.
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| Region 1 | | Type: | Disordered | | Name: | | | Location: | 130 - 146 | | Length: | 17 | | Region sequence: |
NPIPGLDELGVGNSDAA | | Modification type: | Engineered
Fragment
| | PDB: | 1DPR:A | | Structural/functional type: | Function arises from the disordered state
| | Functional classes: | Entropic chain
| | Functional subclasses: | Flexible linkers/spacers
| Detection methods:
- Nuclear magnetic resonance (NMR) (303 K; )
| References:
- Wang G, Wylie GP, Twigg PD, Caspar DL, Murphy JR, Logan TM. "Solution structure and peptide binding studies of the C-terminal src homology 3-like domain of the diphtheria toxin repressor protein." Proc Natl Acad Sci U S A. 1999; 96(11): 6119-24. PubMed: 10339551
| Comments:
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| Comments |
Natural variant, residues 147 and 214.
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