| General information | | DisProt: | DP00378 | | Name: | Transcription factor Sp1 | | Synonym(s): | SP1_HUMAN
| | First appeared in release: | Release 3.0 (02/17/2006) | | UniProt: | P08047 | | UniGene: | Hs.620754 | | SwissProt: | SP1_HUMAN | | TrEMBL: | | | NCBI (GI): | 13638437 | | Source organism: | Homo sapiens (Human) | | Sequence length: | 785 | | Percent disordered: | 3% | | Homologues: | |
| Native sequence |
10 20 30 40 50 60
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MSDQDHSMDE MTAVVKIEKG VGGNNGGNGN GGGAFSQARS SSTGSSSSTG GGGQESQPSP - 60
LALLAATCSR IESPNENSNN SQGPSQSGGT GELDLTATQL SQGANGWQII SSSSGATPTS - 120
KEQSGSSTNG SNGSESSKNR TVSGGQYVVA AAPNLQNQQV LTGLPGVMPN IQYQVIPQFQ - 180
TVDGQQLQFA ATGAQVQQDG SGQIQIIPGA NQQIITNRGS GGNIIAAMPN LLQQAVPLQG - 240
LANNVLSGQT QYVTNVPVAL NGNITLLPVN SVSAATLTPS SQAVTISSSG SQESGSQPVT - 300
SGTTISSASL VSSQASSSSF FTNANSYSTT TTTSNMGIMN FTTSGSSGTN SQGQTPQRVS - 360
GLQGSDALNI QQNQTSGGSL QAGQQKEGEQ NQQTQQQQIL IQPQLVQGGQ ALQALQAAPL - 420
SGQTFTTQAI SQETLQNLQL QAVPNSGPII IRTPTVGPNG QVSWQTLQLQ NLQVQNPQAQ - 480
TITLAPMQGV SLGQTSSSNT TLTPIASAAS IPAGTVTVNA AQLSSMPGLQ TINLSALGTS - 540
GIQVHPIQGL PLAIANAPGD HGAQLGLHGA GGDGIHDDTA GGEEGENSPD AQPQAGRRTR - 600
REACTCPYCK DSEGRGSGDP GKKKQHICHI QGCGKVYGKT SHLRAHLRWH TGERPFMCTW - 660
SYCGKRFTRS DELQRHKRTH TGEKKFACPE CPKRFMRSDH LSKHIKTHQN KKGGPGVALS - 720
VGTLPLDSGA GSEGSGTATP SALITTNMVA MEAICPEGIA RLANSGINVM QVADLQSINI - 780
SGNGF
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| Functional narrative |
Transcription factor that can activate or repress transcription in response to physiological and pathological stimuli. Binds with high affinity to GC-rich motifs and regulates the expression of a large number of genes involved in a variety of processes such as cell growth, apoptosis, differentiation and immune responses. Highly regulated by post-translational modifications (phosphorylations, sumoylation, proteolytic cleavage, glycosylation and acetylation). Binds also the PDGFR-alpha G-box promoter. May have a role in modulating the cellular response to DNA damage. Implicated in chromatin remodeling.
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| Map of ordered and disordered regions |
Note: 'Mouse' over a region to see the start and stop residues. Click on a region to see detailed information.
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| Region 1 | | Type: | Disordered | | Name: | | | Location: | 619 - 625 | | Length: | 7 | | Region sequence: |
DPGKKKQ | | Modification type: | Fragment
| | PDB: | | | Structural/functional type: | Relationship to function unknown
| | Functional classes: | Unknown
| | Functional subclasses: | Unknown
| Detection methods:
- Nuclear magnetic resonance (NMR) (298 K; pH: 7.4; D2O 10 %; DTT 1 mM; NaCl 50 mM; Tris 10 mM)
| References:
- Oka S, Shiraishi Y, Yoshida T, Ohkubo T, Sugiura Y, Kobayashi Y. "NMR structure of transcription factor Sp1 DNA binding domain." Biochemistry. 2004; 43(51): 16027-35. PubMed: 15609997
| Comments:
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| Region 2 | | Type: | Disordered | | Name: | | | Location: | 651 - 655 | | Length: | 5 | | Region sequence: |
TGERP | | Modification type: | Fragment
| | PDB: | | | Structural/functional type: | Function arises via a disorder to order transition
| | Functional classes: | Molecular assembly
Entropic chain
| | Functional subclasses: | Flexible linkers/spacers
| Detection methods:
- Nuclear magnetic resonance (NMR) (298 K; pH: 7.4; D2O 10 %; DTT 1 mM; NaCl 50 mM; Tris 10 mM)
| References:
- Oka S, Shiraishi Y, Yoshida T, Ohkubo T, Sugiura Y, Kobayashi Y. "NMR structure of transcription factor Sp1 DNA binding domain." Biochemistry. 2004; 43(51): 16027-35. PubMed: 15609997
| Comments:
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| Region 3 | | Type: | Disordered | | Name: | | | Location: | 659 - 663 | | Length: | 5 | | Region sequence: |
TWSYC | | Modification type: | Fragment
| | PDB: | | | Structural/functional type: | Relationship to function unknown
| | Functional classes: | Unknown
| | Functional subclasses: | Unknown
| Detection methods:
- Nuclear magnetic resonance (NMR) (298 K; pH: 7.4; D2O 10 %; DTT 1 mM; NaCl 50 mM; Tris 10 mM)
| References:
- Oka S, Shiraishi Y, Yoshida T, Ohkubo T, Sugiura Y, Kobayashi Y. "NMR structure of transcription factor Sp1 DNA binding domain." Biochemistry. 2004; 43(51): 16027-35. PubMed: 15609997
| Comments:
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| Region 4 | | Type: | Disordered | | Name: | | | Location: | 681 - 685 | | Length: | 5 | | Region sequence: |
TGEKK | | Modification type: | Fragment
| | PDB: | | | Structural/functional type: | Function arises via a disorder to order transition
| | Functional classes: | Molecular assembly
Entropic chain
| | Functional subclasses: | Flexible linkers/spacers
| Detection methods:
- Nuclear magnetic resonance (NMR) (298 K; pH: 7.4; D2O 10 %; DTT 1 mM; NaCl 50 mM; Tris 10 mM)
| References:
- Oka S, Shiraishi Y, Yoshida T, Ohkubo T, Sugiura Y, Kobayashi Y. "NMR structure of transcription factor Sp1 DNA binding domain." Biochemistry. 2004; 43(51): 16027-35. PubMed: 15609997
| Comments:
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