Annotations for this protein have been verified by the authors of the corresponding papers


DP00381: Aryl hydrocarbon receptorFASTA viewXML view

General information
DisProt:DP00381
Name:Aryl hydrocarbon receptor
Synonym(s):AHR_HUMAN
Ah receptor
AhR
Class E basic helix-loop-helix protein 76
bHLHe76
First appeared in release:Release 3.0 (02/17/2006)
UniProt:P35869
UniGene:Hs.171189
SwissProt: AHR_HUMAN
TrEMBL:  
NCBI (GI): 3041653
Source organism:Homo sapiens (Human)
Sequence length:848
Percent disordered:20%
Homologues: 


Native sequence

        10         20         30         40         50         60
         |          |          |          |          |          |
MNSSSANITY ASRKRRKPVQ KTVKPIPAEG IKSNPSKRHR DRLNTELDRL ASLLPFPQDV - 60
INKLDKLSVL RLSVSYLRAK SFFDVALKSS PTERNGGQDN CRAANFREGL NLQEGEFLLQ - 120
ALNGFVLVVT TDALVFYASS TIQDYLGFQQ SDVIHQSVYE LIHTEDRAEF QRQLHWALNP - 180
SQCTESGQGI EEATGLPQTV VCYNPDQIPP ENSPLMERCF ICRLRCLLDN SSGFLAMNFQ - 240
GKLKYLHGQK KKGKDGSILP PQLALFAIAT PLQPPSILEI RTKNFIFRTK HKLDFTPIGC - 300
DAKGRIVLGY TEAELCTRGS GYQFIHAADM LYCAESHIRM IKTGESGMIV FRLLTKNNRW - 360
TWVQSNARLL YKNGRPDYII VTQRPLTDEE GTEHLRKRNT KLPFMFTTGE AVLYEATNPF - 420
PAIMDPLPLR TKNGTSGKDS ATTSTLSKDS LNPSSLLAAM MQQDESIYLY PASSTSSTAP - 480
FENNFFNESM NECRNWQDNT APMGNDTILK HEQIDQPQDV NSFAGGHPGL FQDSKNSDLY - 540
SIMKNLGIDF EDIRHMQNEK FFRNDFSGEV DFRDIDLTDE ILTYVQDSLS KSPFIPSDYQ - 600
QQQSLALNSS CMVQEHLHLE QQQQHHQKQV VVEPQQQLCQ KMKHMQVNGM FENWNSNQFV - 660
PFNCPQQDPQ QYNVFTDLHG ISQEFPYKSE MDSMPYTQNF ISCNQPVLPQ HSKCTELDYP - 720
MGSFEPSPYP TTSSLEDFVT CLQLPENQKH GLNPQSAIIT PQTCYAGAVS MYQCQPEPQH - 780
THVGQMQYNP VLPGQQAFLN KFQNGVLNET YPAELNNINN TQTTTHLQPL HHPSEARPFP - 840
DLTSSGFL



Functional narrative    

Ligand-activated transcriptional activator. Binds to the XRE promoter region of genes it activates. Activates the expression of multiple phase I and II xenobiotic chemical metabolizing enzyme genes (such as the CYP1A1 gene). Mediates biochemical and toxic effects of halogenated aromatic hydrocarbons. Involved in cell-cycle regulation. Likely to play an important role in the development and maturation of many tissues.

Region 1: 545-713

Map of ordered and disordered regions







Note: 'Mouse' over a region to see the start and stop residues. Click on a region to see detailed information.


Region 1
Type:Disordered
Name:Transactivation domain
Location:545 - 713
Length:169
Region sequence:

NLGIDFEDIRHMQNEKFFRNDFSGEVDFRDIDLTDEILTYVQDSLSKSPFIPSDYQQQQS
LALNSSCMVQEHLHLEQQQQHHQKQVVVEPQQQLCQKMKHMQVNGMFENWNSNQFVPFNC
PQQDPQQYNVFTDLHGISQEFPYKSEMDSMPYTQNFISCNQPVLPQHSK

Modification type: Engineered
Fragment
Monomeric
Native
PDB:  
Structural/functional type: Function arises via a disorder to order transition
Functional classes: Modification site
Molecular recognition effectors
Molecular assembly
Functional subclasses: Transactivation (transcriptional activation)
Protein-protein binding
Detection methods:
  1. Circular dichroism (CD) spectroscopy, far-UV (293 K; pH: 7; DTT 1 mM; Sodium phosphate (dibasic) 6 mM; Sodium phosphate (monobasic) 4 mM; Sodium sulfate 100 mM)

  2. Sensitivity to proteolysis

  3. Fourier transform infrared spectroscopy (FTIR), aka infrared spectroscopy)

  4. Fluorescence, intrinsic
References:
  1. Watt K, Jess TJ, Kelly SM, Price NC, McEwan IJ. "Induced alpha-helix structure in the aryl hydrocarbon receptor transactivation domain modulates protein-protein interactions." Biochemistry. 2005; 44(2): 734-43. PubMed: 15641800
Comments:
 



References

  1. Hankinson O. "The aryl hydrocarbon receptor complex." Annu Rev Pharmacol Toxicol. 1995; 35: 307-40. PubMed: 7598497


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