| General information | | DisProt: | DP00397 | | Name: | Exostosin-like 2 | | Synonym(s): | EXTL2_MOUSE
EC 2.4.1.223
Glucuronyl-galactosyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase
Alpha-1,4-N-acetylhexosaminyltransferase EXTL2
Alpha-GalNAcT EXTL2
EXT-related protein 2
| | First appeared in release: | Release 3.0 (02/17/2006) | | UniProt: | Q9ES89 | | UniGene: | Mm.41739 | | SwissProt: | EXTL2_MOUSE | | TrEMBL: | | | NCBI (GI): | 20138337 | | Source organism: | Mus musculus (Mouse) | | Sequence length: | 330 | | Percent disordered: | 4% | | Homologues: | |
| Native sequence |
10 20 30 40 50 60
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MMRGCHICKL PGRVMGIRVL RFSLVVILVL LLVAGALTNL LPNIKEDKML TLRREIKSPS - 60
KSALDSFTLI MQTYNRTDLL LRLLNHYQAV PSLHKVIVVW NNVGEKGPEE LWNSLGPHPI - 120
PVIFKPQTAN KMRNRLQVFP EVETNAVLMV DDDTLISAQD LVFAFSIWQQ FPDQIIGFVP - 180
RKHVSTSSGI YSYGGFELQT PGPGNGDQYS MVLIGASFFN SKYLELFQKQ PAAVHALIDE - 240
TQNCDDIAMN FLVTRHTGKP SGIFVKPINM VNLEKETNGY SGMWHRAEHF LQRSYCINKL - 300
VNIYDGMPLK YSNIMISQFG FPYANHKSKM
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| Functional narrative |
Glycosyltransferase required for the biosynthesis of heparan-sulfate and responsible for the alternating addition of beta-1-4-linked glucuronic acid (GlcA) and alpha-1-4-linked N-acetylglucosamine (GlcNAc) units to nascent heparan sulfate chains.
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| Map of ordered and disordered regions |
Note: 'Mouse' over a region to see the start and stop residues. Click on a region to see detailed information.
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| Region 1 | | Type: | Disordered | | Name: | | | Location: | 275 - 288 | | Length: | 14 | | Region sequence: |
KETNGYSGMWHRAE | | Modification type: | Fragment
| | PDB: | | | Structural/functional type: | Function arises via a disorder to order transition
| | Functional classes: | Modification site
Molecular assembly
| | Functional subclasses: | Substrate/ligand binding
| Detection methods:
- X-ray crystallography (HEPES (pH 7.5) 25 mM; MgCl2 200 mM; NaCl 100 mM; PEG 3000 (10-12%); Sodium cacodylate (pH 7.5) 0.1 M)
| References:
- Pedersen LC, Dong J, Taniguchi F, Kitagawa H, Krahn JM, Pedersen LG, Sugahara K, Negishi M. "Crystal structure of an alpha 1,4-N-acetylhexosaminyltransferase (EXTL2), a member of the exostosin gene family involved in heparan sulfate biosynthesis." J Biol Chem. 2003; 278(16): 14420-8. PubMed: 12562774
| Comments:The fragment used to determine the crystal structure consisted of residues 63-327.
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