| General information | | DisProt: | DP00410 | | Name: | Gag-Pol polyprotein | | Synonym(s): | POL_HV1N5
Pr160Gag-Pol
1. Matrix protein p17 [cleavage prod]
2. Capsid protein p24 [cleavage prod]
3. Spacer peptide p2 [cleavage prod]
4. Nucleocapsid protein p7 [cleavage prod]
5. Transframe peptide [cleavage prod]
6. p6-pol [cleavage prod]
7. Protease [cleavage prod]
8. Reverse transcriptase/ribonuclease H [cleavage prod]
9. p51 RT [cleavage prod]
10. p15 [cleavage prod]
11. Integrase [cleavage prod]
Add'l names for cleavage products: 1. MA, 2. CA, 4. NC, 5. TF, 6. p6*, 7. Retropepsin, 7. PR, 8. p66 RT, 11. IN
| | First appeared in release: | Release 1.0 (08/01/2003) | | UniProt: | P12497 | | UniGene: | | | SwissProt: | POL_HV1N5 | | TrEMBL: | | | NCBI (GI): | 6006964 | | Source organism: | Human immunodeficiency virus 1 | | Sequence length: | 1435 | | Percent disordered: | -1% | | Homologues: | |
| Native sequence |
10 20 30 40 50 60
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MGARASVLSG GELDKWEKIR LRPGGKKQYK LKHIVWASRE LERFAVNPGL LETSEGCRQI - 60
LGQLQPSLQT GSEELRSLYN TIAVLYCVHQ RIDVKDTKEA LDKIEEEQNK SKKKAQQAAA - 120
DTGNNSQVSQ NYPIVQNLQG QMVHQAISPR TLNAWVKVVE EKAFSPEVIP MFSALSEGAT - 180
PQDLNTMLNT VGGHQAAMQM LKETINEEAA EWDRLHPVHA GPIAPGQMRE PRGSDIAGTT - 240
STLQEQIGWM THNPPIPVGE IYKRWIILGL NKIVRMYSPT SILDIRQGPK EPFRDYVDRF - 300
YKTLRAEQAS QEVKNWMTET LLVQNANPDC KTILKALGPG ATLEEMMTAC QGVGGPGHKA - 360
RVLAEAMSQV TNPATIMIQK GNFRNQRKTV KCFNCGKEGH IAKNCRAPRK KGCWKCGKEG - 420
HQMKDCTERQ ANFLREDLAF PQGKAREFSS EQTRANSPTR RELQVWGRDN NSLSEAGADR - 480
QGTVSFSFPQ ITLWQRPLVT IKIGGQLKEA LLDTGADDTV LEEMNLPGRW KPKMIGGIGG - 540
FIKVGQYDQI LIEICGHKAI GTVLVGPTPV NIIGRNLLTQ IGCTLNFPIS PIETVPVKLK - 600
PGMDGPKVKQ WPLTEEKIKA LVEICTEMEK EGKISKIGPE NPYNTPVFAI KKKDSTKWRK - 660
LVDFRELNKR TQDFWEVQLG IPHPAGLKQK KSVTVLDVGD AYFSVPLDKD FRKYTAFTIP - 720
SINNETPGIR YQYNVLPQGW KGSPAIFQCS MTKILEPFRK QNPDIVIYQY MDDLYVGSDL - 780
EIGQHRTKIE ELRQHLLRWG FTTPDKKHQK EPPFLWMGYE LHPDKWTVQP IVLPEKDSWT - 840
VNDIQKLVGK LNWASQIYAG IKVRQLCKLL RGTKALTEVV PLTEEAELEL AENREILKEP - 900
VHGVYYDPSK DLIAEIQKQG QGQWTYQIYQ EPFKNLKTGK YARMKGAHTN DVKQLTEAVQ - 960
KIATESIVIW GKTPKFKLPI QKETWEAWWT EYWQATWIPE WEFVNTPPLV KLWYQLEKEP - 1020
IIGAETFYVD GAANRETKLG KAGYVTDRGR QKVVPLTDTT NQKTELQAIH LALQDSGLEV - 1080
NIVTDSQYAL GIIQAQPDKS ESELVSQIIE QLIKKEKVYL AWVPAHKGIG GNEQVDGLVS - 1140
AGIRKVLFLD GIDKAQEEHE KYHSNWRAMA SDFNLPPVVA KEIVASCDKC QLKGEAMHGQ - 1200
VDCSPGIWQL DCTHLEGKVI LVAVHVASGY IEAEVIPAET GQETAYFLLK LAGRWPVKTV - 1260
HTDNGSNFTS TTVKAACWWA GIKQEFGIPY NPQSQGVIES MNKELKKIIG QVRDQAEHLK - 1320
TAVQMAVFIH NFKRKGGIGG YSAGERIVDI IATDIQTKEL QKQITKIQNF RVYYRDSRDP - 1380
VWKGPAKLLW KGEGAVVIQD NSDIKVVPRR KAKIIRDYGK QMAGDDCVAS RQDED
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| Functional narrative |
Gag-Pol polyprotein and Gag polyprotein may regulate their own translation, by binding genomic RNA in the 5'-UTR. At low concentration, Gag-Pol and Gag would promote translation, whereas at high concentration, the polyproteins encapsidate genomic RNA and then shut off translation. (UniProt)
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| Map of ordered and disordered regions |
Note: 'Mouse' over a region to see the start and stop residues. Click on a region to see detailed information.
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| Comments |
Previous entry DP00410 has been split into polyprotein (DP00410) and cleavage product
DP00410_C011. Disorder is characterized on the cleavage product.
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