| General information | | DisProt: | DP00463 | | Name: | Gamma-aminobutyric acid type B receptor subunit 1 [Isoform 1E (1C)] | | Synonym(s): | GABR1_RAT
GABA-B receptor 1
GABA-B-R1
GABA-BR1
GABABR1
Gb1
| | First appeared in release: | Release 3.1 (03/31/2006) | | UniProt: | Q9Z0U4-1 | | UniGene: | Rn.30059 | | SwissProt: | GABR1_RAT | | TrEMBL: | | | NCBI (GI): | 12643494 | | Source organism: | Rattus norvegicus (Rat) | | Sequence length: | 991 | | Percent disordered: | 7% | | Homologues: | |
| Native sequence |
10 20 30 40 50 60
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MLLLLLVPLF LRPLGAGGAQ TPNATSEGCQ IIHPPWEGGI RYRGLTRDQV KAINFLPVDY - 60
EIEYVCRGER EVVGPKVRKC LANGSWTDMD TPSRCVRICS KSYLTLENGK VFLTGGDLPA - 120
LDGARVEFRC DPDFHLVGSS RSVCSQGQWS TPKPHCQVNR TPHSERRAVY IGALFPMSGG - 180
WPGGQACQPA VEMALEDVNS RRDILPDYEL KLIHHDSKCD PGQATKYLYE LLYNDPIKII - 240
LMPGCSSVST LVAEAARMWN LIVLSYGSSS PALSNRQRFP TFFRTHPSAT LHNPTRVKLF - 300
EKWGWKKIAT IQQTTEVFTS TLDDLEERVK EAGIEITFRQ SFFSDPAVPV KNLKRQDARI - 360
IVGLFYETEA RKVFCEVYKE RLFGKKYVWF LIGWYADNWF KTYDPSINCT VEEMTEAVEG - 420
HITTEIVMLN PANTRSISNM TSQEFVEKLT KRLKRHPEET GGFQEAPLAY DAIWALALAL - 480
NKTSGGGGRS GVRLEDFNYN NQTITDQIYR AMNSSSFEGV SGHVVFDASG SRMAWTLIEQ - 540
LQGGSYKKIG YYDSTKDDLS WSKTDKWIGG SPPADQTLVI KTFRFLSQKL FISVSVLSSL - 600
GIVLAVVCLS FNIYNSHVRY IQNSQPNLNN LTAVGCSLAL AAVFPLGLDG YHIGRSQFPF - 660
VCQARLWLLG LGFSLGYGSM FTKIWWVHTV FTKKEEKKEW RKTLEPWKLY ATVGLLVGMD - 720
VLTLAIWQIV DPLHRTIETF AKEEPKEDID VSILPQLEHC SSKKMNTWLG ELWSFAVSSD - 780
VQRRATVGGD SPICVWPAPE SIFYGYKGLL LLLGIFLAYE TKSVSTEKIN DHRAVGMAIY - 840
NVAVLCLITA PVTMILSSQQ DAAFAFASLA IVFSSYITLV VLFVPKMRRL ITRGEWQSET - 900
QDTMKTGSST NNNEEEKSRL LEKENRELEK IIAEKEERVS ELRHQLQSRQ QLRSRRHPPT - 960
PPDPSGGLPR GPSEPPDRLS CDGSRVHLLY K
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| Functional narrative |
Receptor for GABA. The activity of this receptor is mediated by G-proteins that inhibit adenylyl cyclase activity, stimulates phospholipase A2, activates potassium channels, inactivates voltage-dependent calcium-channels and modulates inositol phospholipids hydrolysis. Plays a critical role in the fine-tuning of inhibitory synaptic transmission. Pre-synaptic GABA-B-R inhibit neurotransmitter release by down-regulating high-voltage activated calcium channels, whereas postsynaptic GABA-B-R decrease neuronal excitability by activating a prominent inwardly rectifying potassium (Kir) conductance that underlies the late inhibitory postsynaptic potentials. Not only implicated in synaptic inhibition but also in hippocampal long-term potentiation, slow wave sleep, muscle relaxation and antinociception.
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| Map of ordered and disordered regions |
Note: 'Mouse' over a region to see the start and stop residues. Click on a region to see detailed information.
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| Region 1 | | Type: | Disordered - Molten Globule | | Name: | GABAB R1a - CCP1 | | Location: | 29 - 95 | | Length: | 67 | | Region sequence: |
CQIIHPPWEGGIRYRGLTRDQVKAINFLPVDYEIEYVCRGEREVVGPKVRKCLANGSWTD
MDTPSRC | | Modification type: | Fragment
| | PDB: | | | Structural/functional type: | Function arises from the disordered state
| | Functional classes: | Molecular recognition effectors
| | Functional subclasses: | Protein-protein binding
| Detection methods:
- Nuclear magnetic resonance (NMR) (298 K; H2O/D2O (90%/10%); sodium acetate (pH 4.0) 20 mM)
- Circular dichroism (CD) spectroscopy, far-UV (293 K; sodium phosphate (pH 7.5) 20 mM)
- Circular dichroism (CD) spectroscopy, near-UV (293 K; sodium phosphate (pH 7.5))
| References:
- Blein S, Ginham R, Uhrin D, Smith BO, Soares DC, Veltel S, McIlhinney RA, White JH, Barlow PN. "Structural analysis of the complement control protein (CCP) modules of GABA(B) receptor 1a: only one of the two CCP modules is compactly folded." J Biol Chem. 2004; 279(46): 48292-306. PubMed: 15304491
| Comments:This region corresponds to the N-terminal CCP-module like sequence.
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| References |
- Kaupmann K, Huggel K, Heid J, Flor PJ, Bischoff S, Mickel SJ, McMaster G, Angst C, Bittiger H, Froestl W, Bettler B. "Expression cloning of GABA(B) receptors uncovers similarity to metabotropic glutamate receptors." Nature. 1997; 386(6622): 239-46. PubMed: 9069281
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| Comments |
This is one of the subunits compromising the heterodimeric GABA B receptor.
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| If you have any comments or wish to provide additional references to this protein or its disordered region(s), please click here to e-mail us. |
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