| General information | | DisProt: | DP00491 | | Name: | Dystroglycan | | Synonym(s): | DAG1_MOUSE
Dystrophin-associated glycoprotein 1
1. Alpha-dystroglycan [cleavage product]
Alpha-DG
2. Beta-dystroglycan [cleavage product]
Beta-DG
| | First appeared in release: | Release 5.4 (10/14/2010) | | UniProt: | Q62165 | | UniGene: | | | SwissProt: | DAG1_MOUSE | | TrEMBL: | | | NCBI (GI): | | | Source organism: | Mus musculus (Mouse) | | Sequence length: | 893 | | Percent disordered: | -1% | | Homologues: | |
| Native sequence |
10 20 30 40 50 60
| | | | | |
MSVDNWLLHP LWGQTFLLLL SVAVAQAHWP SEPSEAVRDW KNQLEASMHS VLSDFQEAVP - 60
TVVGIPDGTA VVGRSFRVSI PTDLIASSGE IIKVSAAGKE ALPSWLHWDP HSHILEGLPL - 120
DTDKGVHYIS VSAARLGANG SHVPQTSSVF SIEVYPEDHN EPQSVRAASS DPGEVVPSAC - 180
AADEPVTVLT VILDADLTKM TPKQRIDLLN RMQSFSEVEL HNMKLVPVVN NRLFDMSAFM - 240
AGPGNAKKVV ENGALLSWKL GCSLNQNSVP DIRGVETPAR EGAMSAQLGY PVVGWHIANK - 300
KPTLPKRLRR QIHATPTPVT AIGPPTTAIQ EPPSRIVPTP TSPAIAPPTE TMAPPVRDPV - 360
PGKPTVTIRT RGAIIQTPTL GPIQPTRVSE AGTTVPGQIR PTLTIPGYVE PTAVITPPTT - 420
TTKKPRVSTP KPATPSTDSS TTTTRRPTKK PRTPRPVPRV TTKAPITRLE TASPPTRIRT - 480
TTSGVPRGGE PNQRPELKNH IDRVDAWVGT YFEVKIPSDT FYDNEDTTTD KLKLTLKLRE - 540
QQLVGEKSWV QFNSNSQLMY GLPDSSHVGK HEYFMHATDK GGLSAVDAFE IHVHKRPQGD - 600
KAPARFKARL AGDPAPVVND IHKKIALVKK LAFAFGDRNC SSITLQNITR GSIVVEWTNN - 660
TLPLEPCPKE QIIGLSRRIA DENGKPRPAF SNALEPDFKA LSIAVTGSGS CRHLQFIPVA - 720
PPSPGSSAAP ATEVPDRDPE KSSEDDVYLH TVIPAVVVAA ILLIAGIIAM ICYRKKRKGK - 780
LTLEDQATFI KKGVPIIFAD ELDDSKPPPS SSMPLILQEE KAPLPPPEYP NQSMPETTPL - 840
NQDTVGEYTP LRDEDPNAPP YQPPPPFTAP MEGKGSRPKN MTPYRSPPPY VPP
|
| Functional narrative |
Function: Forms part of the dystrophin-associated protein complex (DAPC) which may link the cytoskeleton to the extracellular matrix.
SUBUNIT: Interacts with AGR2 and AGR3 (By similarity). Interacts with SGCD.
Subcellular Location: Alpha-dystroglycan: Secreted, extracellular space.
Subcellular Location: Beta-dystroglycan: Cell membrane; Single- pass type I membrane protein. Cytoplasm, cytoskeleton.
TISSUE SPECIFICITY: Expressed in a variety of tissues. In brain, expressed in the hippocampal formation, the olfactory bulb, the cerebellum and the thalamus.
DEVELOPMENTAL STAGE: Broadly expressed in late embryonic and early postnatal cerebellar neurons, including premigratory granule neurons of the external granule cell layer, but expression is largely down-regulated. Weak expression in Purkinje cells throughout development. Alpha- and beta-DG proteins are also present on the Bergmann glial scaffolds used by granule cells during early postnatal radial migration.
PTM: Thr-377 is glycosylated by a trisaccharide with the structure 2-(N-acetylamido)-2-deoxygalactosyl-beta-1,3-2-(N-acetylamido)-2- deoxyglucosyl-beta-1,4-6-phosphomannose (By similarity).
SIMILARITY: Contains 1 peptidase S72 domain.
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| Map of ordered and disordered regions |
Note: 'Mouse' over a region to see the start and stop residues. Click on a region to see detailed information.
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| Comments |
Previous entry DP00491 has been split into polyprotein (DP00491) and cleavage product
DP00491_C002. Disorder is characterized on the cleavage product.
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