Annotations for this protein have been verified by the authors of the corresponding papers



DP00503: B-cell antigen receptor complex-associated protein beta chain [Isoform Long]FASTA viewXML view

General information
DisProt:DP00503
Name:B-cell antigen receptor complex-associated protein beta chain [Isoform Long]
Synonym(s):CD79B_HUMAN
Ig-beta
B-cell-specific glycoprotein B29
Immunoglobulin-associated B29 protein
Antigen CD79b
First appeared in release:Release 3.2 (05/26/2006)
UniProt:P40259-1
UniGene:Hs.89575
SwissProt: CD79B_HUMAN
TrEMBL:  
NCBI (GI): 728994
Source organism:Homo sapiens (Human)
Sequence length:229
Percent disordered:21%
Homologues: 


Native sequence

        10         20         30         40         50         60
         |          |          |          |          |          |
MARLALSPVP SHWMVALLLL LSAEPVPAAR SEDRYRNPKG SACSRIWQSP RFIARKRGFT - 60
VKMHCYMNSA SGNVSWLWKQ EMDENPQQLK LEKGRMEESQ NESLATLTIQ GIRFEDNGIY - 120
FCQQKCNNTS EVYQGCGTEL RVMGFSTLAQ LKQRNTLKDG IIMIQTLLII LFIIVPIFLL - 180
LDKDDSKAGM EEDHTYEGLD IDQTATYEDI VTLRTGEVKW SVGEHPGQE



Functional narrative    

The B cell antigen receptor (BCR) consissts of the membrane-bound immunoglobulin molecule as the antigen-binding subunit and the Ig-alpha/Ig-beta disulfide-linked heterodimer as the signaling subunit. The BCR Ig alpha chain is involved in transmembrane signal transduction. The Ig alpha chain is a membrane, single pass type I membrane protein. This protein was characterized by the analysis of a recombinant soluble fragment of this subunit, corresponding to the cytoplasmic domain of the molecule and containing residues 181-229. Required in cooperation with CD79A for initiation of the signal transduction cascade activated by the B-cell antigen receptor complex (BCR) which leads to internalization of the complex, trafficking to late endosomes and antigen presentation. Enhances phosphorylation of CD79A, possibly by recruiting kinases which phosphorylate CD79A or by recruiting proteins which bind to CD79A and protect it from dephosphorylation.

Region 1: 181-229

Map of ordered and disordered regions







Note: 'Mouse' over a region to see the start and stop residues. Click on a region to see detailed information.


Region 1
Type:Disordered
Name:Cytoplasmic domain of the BCR Ig beta chain
Location:181 - 229
Length:49
Region sequence:

LDKDDSKAGMEEDHTYEGLDIDQTATYEDIVTLRTGEVKWSVGEHPGQE

Modification type: Fragment
Native
PDB:  
Structural/functional type: Function arises from the disordered state
Functional classes: Molecular recognition effectors
Molecular recognition scavengers
Functional subclasses: Polymerization
Phosphorylation
Protein-protein binding
Detection methods:
  1. Fluorescence polarization/anisotropy (298 K; PBS (pH 7.0))

References:
  1. Sigalov A, Aivazian D, Stern L. "Homooligomerization of the cytoplasmic domain of the T cell receptor zeta chain and of other proteins containing the immunoreceptor tyrosine-based activation motif." Biochemistry. 2004; 43(7): 2049-61. PubMed: 14967045

Comments:
 



References

  1. Hashimoto S, Gregersen PK, Chiorazzi N. "The human Ig-beta cDNA sequence, a homologue of murine B29, is identical in B cell and plasma cell lines producing all the human Ig isotypes." J Immunol. 1993; 150(2): 491-8. PubMed: 8419481


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