General information | DisProt: | DP00503 | Name: | B-cell antigen receptor complex-associated protein beta chain [Isoform Long] | Synonym(s): | CD79B_HUMAN
Ig-beta
B-cell-specific glycoprotein B29
Immunoglobulin-associated B29 protein
Antigen CD79b
| First appeared in release: | Release 3.2 (05/26/2006) | UniProt: | P40259-1 | UniGene: | Hs.89575 | SwissProt: | CD79B_HUMAN | TrEMBL: | | NCBI (GI): | 728994 | Source organism: | Homo sapiens (Human) | Sequence length: | 229 | Percent disordered: | 21% | Homologues: | |
Native sequence |
10 20 30 40 50 60 | | | | | | MARLALSPVP SHWMVALLLL LSAEPVPAAR SEDRYRNPKG SACSRIWQSP RFIARKRGFT - 60 VKMHCYMNSA SGNVSWLWKQ EMDENPQQLK LEKGRMEESQ NESLATLTIQ GIRFEDNGIY - 120 FCQQKCNNTS EVYQGCGTEL RVMGFSTLAQ LKQRNTLKDG IIMIQTLLII LFIIVPIFLL - 180 LDKDDSKAGM EEDHTYEGLD IDQTATYEDI VTLRTGEVKW SVGEHPGQE
|
Functional narrative |
The B cell antigen receptor (BCR) consissts of the membrane-bound immunoglobulin molecule as the antigen-binding subunit and the Ig-alpha/Ig-beta disulfide-linked heterodimer as the signaling subunit. The BCR Ig alpha chain is involved in transmembrane signal transduction. The Ig alpha chain is a membrane, single pass type I membrane protein. This protein was characterized by the analysis of a recombinant soluble fragment of this subunit, corresponding to the cytoplasmic domain of the molecule and containing residues 181-229. Required in cooperation with CD79A for initiation of the signal transduction cascade activated by the B-cell antigen receptor complex (BCR) which leads to internalization of the complex, trafficking to late endosomes and antigen presentation. Enhances phosphorylation of CD79A, possibly by recruiting kinases which phosphorylate CD79A or by recruiting proteins which bind to CD79A and protect it from dephosphorylation.
|
Map of ordered and disordered regions |
Note: 'Mouse' over a region to see the start and stop residues. Click on a region to see detailed information.
|
Region 1 | Type: | Disordered | Name: | Cytoplasmic domain of the BCR Ig beta chain | Location: | 181 - 229 | Length: | 49 | Region sequence: |
LDKDDSKAGMEEDHTYEGLDIDQTATYEDIVTLRTGEVKWSVGEHPGQE | Modification type: | Fragment
Native
| PDB: | | Structural/functional type: | Function arises from the disordered state | Functional classes: | Molecular recognition effectors
Molecular recognition scavengers
| Functional subclasses: | Polymerization
Phosphorylation
Protein-protein binding
| Detection methods:
- Fluorescence polarization/anisotropy (298 K; PBS (pH 7.0))
| References:
- Sigalov A, Aivazian D, Stern L. "Homooligomerization of the cytoplasmic domain of the T cell receptor zeta chain and of other proteins containing the immunoreceptor tyrosine-based activation motif." Biochemistry. 2004; 43(7): 2049-61. PubMed: 14967045
| Comments:
|
References |
- Hashimoto S, Gregersen PK, Chiorazzi N. "The human Ig-beta cDNA sequence, a homologue of murine B29, is identical in B cell and plasma cell lines producing all the human Ig isotypes." J Immunol. 1993; 150(2): 491-8. PubMed: 8419481
|
If you have any comments or wish to provide additional references to this protein or its disordered region(s), please click here to e-mail us. |
Disprot-footer
|