Annotations for this protein have been verified by the authors of the corresponding papers



DP00505: T-cell surface glycoprotein CD3 delta chainFASTA viewXML view

General information
DisProt:DP00505
Name:T-cell surface glycoprotein CD3 delta chain
Synonym(s):CD3D_HUMAN
T-cell receptor T3 delta chain
Antigen CD3d
First appeared in release:Release 3.2 (05/26/2006)
UniProt:P04234
UniGene:Hs.504048
SwissProt: CD3D_HUMAN
TrEMBL:  
NCBI (GI): 115985
Source organism:Homo sapiens (Human)
Sequence length:171
Percent disordered:26%
Homologues: 


Native sequence

        10         20         30         40         50         60
         |          |          |          |          |          |
MEHSTFLSGL VLATLLSQVS PFKIPIEELE DRVFVNCNTS ITWVEGTVGT LLSDITRLDL - 60
GKRILDPRGI YRCNGTDIYK DKESTVQVHY RMCQSCVELD PATVAGIIVT DVIATLLLAL - 120
GVFCFAGHET GRLSGAADTQ ALLRNDQVYQ PLRDRDDAQY SHLGGNWARN K



Functional narrative    

The CD3 complex mediates signal transduction.

Region 1: 127-171

Map of ordered and disordered regions







Note: 'Mouse' over a region to see the start and stop residues. Click on a region to see detailed information.


Region 1
Type:Disordered
Name:Cytoplasmic domain of the CD3 delta chain
Location:127 - 171
Length:45
Region sequence:

GHETGRLSGAADTQALLRNDQVYQPLRDRDDAQYSHLGGNWARNK

Modification type: Fragment
Native
PDB:  
Structural/functional type: Function arises from the disordered state
Functional classes: Molecular recognition effectors
Molecular assembly
Functional subclasses: Polymerization
Phosphorylation
Protein-protein binding
Detection methods:
  1. Circular dichroism (CD) spectroscopy, far-UV (298 K; pH: 7.4; )

References:
  1. Sigalov A, Aivazian D, Stern L. "Homooligomerization of the cytoplasmic domain of the T cell receptor zeta chain and of other proteins containing the immunoreceptor tyrosine-based activation motif." Biochemistry. 2004; 43(7): 2049-61. PubMed: 14967045

Comments:
 



References

  1. Tunnacliffe A, Sims JE, Rabbitts TH. "T3 delta pre-mRNA is transcribed from a non-TATA promoter and is alternatively spliced in human T cells." Embo J. 1986; 5(6): 1245-52. PubMed: 3488209


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