Annotations for this protein have been verified by the authors of the corresponding papers



DP00506: T-cell surface glycoprotein CD3 epsilon chainFASTA viewXML view

General information
DisProt:DP00506
Name:T-cell surface glycoprotein CD3 epsilon chain
Synonym(s):CD3E_HUMAN
T-cell surface antigen T3/Leu-4 epsilon chain
Antigen CD3e
First appeared in release:Release 3.2 (05/26/2006)
UniProt:P07766
UniGene:Hs.3003
SwissProt: CD3E_HUMAN
TrEMBL:  
NCBI (GI): 1345708
Source organism:Homo sapiens (Human)
Sequence length:207
Percent disordered:27%
Homologues: 


Native sequence

        10         20         30         40         50         60
         |          |          |          |          |          |
MQSGTHWRVL GLCLLSVGVW GQDGNEEMGG ITQTPYKVSI SGTTVILTCP QYPGSEILWQ - 60
HNDKNIGGDE DDKNIGSDED HLSLKEFSEL EQSGYYVCYP RGSKPEDANF YLYLRARVCE - 120
NCMEMDVMSV ATIVIVDICI TGGLLLLVYY WSKNRKAKAK PVTRGAGAGG RQRGQNKERP - 180
PPVPNPDYEP IRKGQRDLYS GLNQRRI



Functional narrative    

The CD3 complex mediates signal transduction.

Region 1: 153-207

Map of ordered and disordered regions







Note: 'Mouse' over a region to see the start and stop residues. Click on a region to see detailed information.


Region 1
Type:Disordered
Name:Cytoplasmic domain
Location:153 - 207
Length:55
Region sequence:

KNRKAKAKPVTRGAGAGGRQRGQNKERPPPVPNPDYEPIRKGQRDLYSGLNQRRI

Modification type: Fragment
Native
PDB:  
Structural/functional type: Function arises from the disordered state
Functional classes: Molecular recognition effectors
Molecular assembly
Functional subclasses: Polymerization
Phosphorylation
Protein-protein binding
Detection methods:
  1. Circular dichroism (CD) spectroscopy, far-UV (298 K; pH: 7.4; )

References:
  1. Sigalov A, Aivazian D, Stern L. "Homooligomerization of the cytoplasmic domain of the T cell receptor zeta chain and of other proteins containing the immunoreceptor tyrosine-based activation motif." Biochemistry. 2004; 43(7): 2049-61. PubMed: 14967045

Comments:
 



References

  1. Clevers HC, Dunlap S, Wileman TE, Terhorst C. "Human CD3-epsilon gene contains three miniexons and is transcribed from a non-TATA promoter." Proc Natl Acad Sci U S A. 1988; 85(21): 8156-60. PubMed: 3267235


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