General information | DisProt: | DP00506 | Name: | T-cell surface glycoprotein CD3 epsilon chain | Synonym(s): | CD3E_HUMAN
T-cell surface antigen T3/Leu-4 epsilon chain
Antigen CD3e
| First appeared in release: | Release 3.2 (05/26/2006) | UniProt: | P07766 | UniGene: | Hs.3003 | SwissProt: | CD3E_HUMAN | TrEMBL: | | NCBI (GI): | 1345708 | Source organism: | Homo sapiens (Human) | Sequence length: | 207 | Percent disordered: | 27% | Homologues: | |
Native sequence |
10 20 30 40 50 60 | | | | | | MQSGTHWRVL GLCLLSVGVW GQDGNEEMGG ITQTPYKVSI SGTTVILTCP QYPGSEILWQ - 60 HNDKNIGGDE DDKNIGSDED HLSLKEFSEL EQSGYYVCYP RGSKPEDANF YLYLRARVCE - 120 NCMEMDVMSV ATIVIVDICI TGGLLLLVYY WSKNRKAKAK PVTRGAGAGG RQRGQNKERP - 180 PPVPNPDYEP IRKGQRDLYS GLNQRRI
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Functional narrative |
The CD3 complex mediates signal transduction.
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Map of ordered and disordered regions |
Note: 'Mouse' over a region to see the start and stop residues. Click on a region to see detailed information.
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Region 1 | Type: | Disordered | Name: | Cytoplasmic domain | Location: | 153 - 207 | Length: | 55 | Region sequence: |
KNRKAKAKPVTRGAGAGGRQRGQNKERPPPVPNPDYEPIRKGQRDLYSGLNQRRI | Modification type: | Fragment
Native
| PDB: | | Structural/functional type: | Function arises from the disordered state | Functional classes: | Molecular recognition effectors
Molecular assembly
| Functional subclasses: | Polymerization
Phosphorylation
Protein-protein binding
| Detection methods:
- Circular dichroism (CD) spectroscopy, far-UV (298 K; pH: 7.4; )
| References:
- Sigalov A, Aivazian D, Stern L. "Homooligomerization of the cytoplasmic domain of the T cell receptor zeta chain and of other proteins containing the immunoreceptor tyrosine-based activation motif." Biochemistry. 2004; 43(7): 2049-61. PubMed: 14967045
| Comments:
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References |
- Clevers HC, Dunlap S, Wileman TE, Terhorst C. "Human CD3-epsilon gene contains three miniexons and is transcribed from a non-TATA promoter." Proc Natl Acad Sci U S A. 1988; 85(21): 8156-60. PubMed: 3267235
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