Annotations for this protein have been verified by the authors of the corresponding papers


DP00509: High affinity immunoglobulin epsilon receptor subunit gammaFASTA viewXML view

General information
DisProt:DP00509
Name:High affinity immunoglobulin epsilon receptor subunit gamma
Synonym(s):FCERG_HUMAN
IgE Fc receptor subunit gamma
FceRI gamma
Fc-epsilon RI-gamma
First appeared in release:Release 3.2 (05/26/2006)
UniProt:P30273
UniGene:Hs.433300
SwissProt: FCERG_HUMAN
TrEMBL:  
NCBI (GI): 232085
Source organism:Homo sapiens (Human)
Sequence length:86
Percent disordered:49%
Homologues: 


Native sequence

        10         20         30         40         50         60
         |          |          |          |          |          |
MIPAVVLLLL LLVEQAAALG EPQLCYILDA ILFLYGIVLT LLYCRLKIQV RKAAITSYEK - 60
SDGVYTGLST RNQETYETLK HEKPPQ



Functional narrative    

Associates with a variety of FcR alpha chains to form a functional signaling complex. Regulates several aspects of the immune response. The gamma subunit has a critical role in allowing the IgE Fc receptor to reach the cell surface.

Region 1: 45-86

Map of ordered and disordered regions







Note: 'Mouse' over a region to see the start and stop residues. Click on a region to see detailed information.


Region 1
Type:Disordered
Name:Cytoplasmic domain
Location:45 - 86
Length:42
Region sequence:

RLKIQVRKAAITSYEKSDGVYTGLSTRNQETYETLKHEKPPQ

Modification type: Fragment
Native
PDB:  
Structural/functional type: Function arises from the disordered state
Functional classes: Molecular recognition effectors
Molecular assembly
Functional subclasses: Polymerization
Phosphorylation
Protein-protein binding
Detection methods:
  1. Circular dichroism (CD) spectroscopy, far-UV (298 K; pH: 7.4; )
References:
  1. Sigalov A, Aivazian D, Stern L. "Homooligomerization of the cytoplasmic domain of the T cell receptor zeta chain and of other proteins containing the immunoreceptor tyrosine-based activation motif." Biochemistry. 2004; 43(7): 2049-61. PubMed: 14967045
Comments:
 



References

  1. Kuster H, Thompson H, Kinet JP. "Characterization and expression of the gene for the human Fc receptor gamma subunit. Definition of a new gene family." J Biol Chem. 1990; 265(11): 6448-52. PubMed: 2138619


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