| General information | | DisProt: | DP00512 | | Name: | 50S ribosomal protein L11 | | Synonym(s): | RL11_BACST
| | First appeared in release: | Release 3.3 (06/23/2006) | | UniProt: | P56210 | | UniGene: | | | SwissProt: | RL11_BACST | | TrEMBL: | | | NCBI (GI): | 2829479 | | Source organism: | Bacillus stearothermophilus (Geobacillus stearothermophilus) | | Sequence length: | 133 | | Percent disordered: | 9% | | Homologues: | |
| Native sequence |
10 20 30 40 50 60
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MKLQIPAGKA NPAPPVGPAL GQAGVNIMAF CKEFNARTAD QAGLIIPVEI TVFEDRSFTF - 60
ITKTPPAAVL LKKAAGIESG SGEPNRNKVA TIKRDKVREI AELKMPDLNA ASIEAAMRMI - 120
EGTARSMGIV VED
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| Functional narrative |
This protein binds directly to 23S ribosomal RNA.
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| Map of ordered and disordered regions |
Note: 'Mouse' over a region to see the start and stop residues. Click on a region to see detailed information.
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| Region 1 | | Type: | Disordered | | Name: | loop between helix alpha 1 and strand beta 1 | | Location: | 78 - 89 | | Length: | 12 | | Region sequence: |
ESGSGEPNRNKV | | Modification type: | Fragment
| | PDB: | 1ACI:A, 1FOW:A, 1FOX:A, 1FOY:A, 2FOW:A | | Structural/functional type: | Function arises via a disorder to order transition
| | Functional classes: | Molecular recognition effectors
| | Functional subclasses: | Protein-genomic RNA binding
| Detection methods:
- Nuclear magnetic resonance (NMR) (298 K; pH: 6.1; K2HPO4 10 mM; KCl 25 mM; MgCl2 2 mM)
| References:
- Hinck AP, Markus MA, Huang S, Grzesiek S, Kustonovich I, Draper DE, Torchia DA. "The RNA binding domain of ribosomal protein L11: three-dimensional structure of the RNA-bound form of the protein and its interaction with 23 S rRNA." J Mol Biol. 1997; 274(1): 101-13. PubMed: 9398519
- Markus MA, Hinck AP, Huang S, Draper DE, Torchia DA. "High resolution solution structure of ribosomal protein L11-C76, a helical protein with a flexible loop that becomes structured upon binding to RNA." Nat Struct Biol. 1997; 4(1): 70-7. PubMed: 8989327
| Comments:Experimentally characterized region 1 was studied in the context of the C-terminal domain of the protein, 76 amino acids total length.
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| References |
- Liljas A. "Comparative biochemistry and biophysics of ribosomal proteins." Int Rev Cytol. 1991; 124: 103-36. PubMed: 2001915
- Xing Y, Draper DE. "Stabilization of a ribosomal RNA tertiary structure by ribosomal protein L11." J Mol Biol. 1995; 249(2): 319-31. PubMed: 7783196
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