Annotation for this protein is in progress - please check future releases for more complete information



DP00516: Undecaprenyl pyrophosphate synthetaseFASTA viewXML view

General information
DisProt:DP00516
Name:Undecaprenyl pyrophosphate synthetase
Synonym(s):UPPS_ECOLI
UPP synthetase
EC=2.5.1.31
Di-trans,poly-cis-decaprenylcistransferase
Undecaprenyl diphosphate synthase
UDS
First appeared in release:Release 3.5 (12/22/2006)
UniProt:P60472
UniGene: 
SwissProt: UPPS_ECOLI
TrEMBL:  
NCBI (GI): 42560512
Source organism:Escherichia coli (Strain K12)
Sequence length:253
Percent disordered:5%
Homologues: 


Native sequence

        10         20         30         40         50         60
         |          |          |          |          |          |
MMLSATQPLS EKLPAHGCRH VAIIMDGNGR WAKKQGKIRA FGHKAGAKSV RRAVSFAANN - 60
GIEALTLYAF SSENWNRPAQ EVSALMELFV WALDSEVKSL HRHNVRLRII GDTSRFNSRL - 120
QERIRKSEAL TAGNTGLTLN IAANYGGRWD IVQGVRQLAE KVQQGNLQPD QIDEEMLNQH - 180
VCMHELAPVD LVIRTGGEHR ISNFLLWQIA YAELYFTDVL WPDFDEQDFE GALNAFANRE - 240
RRFGGTEPGD ETA



Functional narrative    

Generates undecaprenyl pyrophosphate (UPP) from isopentenyl pyrophosphate (IPP). UPP is the precursor of glycosyl carrier lipid in the biosynthesis of bacterial cell wall polysaccharide components such as peptidoglycan and lipopolysaccharide.

Region 1: 72-83

Map of ordered and disordered regions







Note: 'Mouse' over a region to see the start and stop residues. Click on a region to see detailed information.


Region 1
Type:Disordered
Name:flexible loop
Location:72 - 83
Length:12
Region sequence:

SENWNRPAQEVS

Modification type:  
PDB:  
Structural/functional type:  
Functional classes: Unknown
Functional subclasses: Flexible linkers/spacers
Detection methods:
  1. X-ray crystallography

References:
  1. Ko TP, Chen YK, Robinson H, Tsai PC, Gao YG, Chen AP, Wang AH, Liang PH. "Mechanism of product chain length determination and the role of a flexible loop in Escherichia coli undecaprenyl-pyrophosphate synthase catalysis." J Biol Chem. 2001; 276(50): 47474-82. PubMed: 11581264

Comments:
 


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