| General information | | DisProt: | DP00516 | | Name: | Undecaprenyl pyrophosphate synthetase | | Synonym(s): | UPPS_ECOLI
UPP synthetase
EC=2.5.1.31
Di-trans,poly-cis-decaprenylcistransferase
Undecaprenyl diphosphate synthase
UDS
| | First appeared in release: | Release 3.5 (12/22/2006) | | UniProt: | P60472 | | UniGene: | | | SwissProt: | UPPS_ECOLI | | TrEMBL: | | | NCBI (GI): | 42560512 | | Source organism: | Escherichia coli (Strain K12) | | Sequence length: | 253 | | Percent disordered: | 5% | | Homologues: | |
| Native sequence |
10 20 30 40 50 60
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MMLSATQPLS EKLPAHGCRH VAIIMDGNGR WAKKQGKIRA FGHKAGAKSV RRAVSFAANN - 60
GIEALTLYAF SSENWNRPAQ EVSALMELFV WALDSEVKSL HRHNVRLRII GDTSRFNSRL - 120
QERIRKSEAL TAGNTGLTLN IAANYGGRWD IVQGVRQLAE KVQQGNLQPD QIDEEMLNQH - 180
VCMHELAPVD LVIRTGGEHR ISNFLLWQIA YAELYFTDVL WPDFDEQDFE GALNAFANRE - 240
RRFGGTEPGD ETA
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| Functional narrative |
Generates undecaprenyl pyrophosphate (UPP) from isopentenyl pyrophosphate (IPP). UPP is the precursor of glycosyl carrier lipid in the biosynthesis of bacterial cell wall polysaccharide components such as peptidoglycan and lipopolysaccharide.
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| Map of ordered and disordered regions |
Note: 'Mouse' over a region to see the start and stop residues. Click on a region to see detailed information.
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| Region 1 | | Type: | Disordered | | Name: | flexible loop | | Location: | 72 - 83 | | Length: | 12 | | Region sequence: |
SENWNRPAQEVS | | Modification type: | | | PDB: | | | Structural/functional type: | | | Functional classes: | Unknown
| | Functional subclasses: | Flexible linkers/spacers
| Detection methods:
- X-ray crystallography
| References:
- Ko TP, Chen YK, Robinson H, Tsai PC, Gao YG, Chen AP, Wang AH, Liang PH. "Mechanism of product chain length determination and the role of a flexible loop in Escherichia coli undecaprenyl-pyrophosphate synthase catalysis." J Biol Chem. 2001; 276(50): 47474-82. PubMed: 11581264
| Comments:
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