| General information | | DisProt: | DP00535 | | Name: | Synaptopodin 2 variant | | Synonym(s): | A7UMX5_MELGA
Fesselin
| | First appeared in release: | Release 3.7 (01/28/2008) | | UniProt: | A7UMX5 | | UniGene: | Mga.4801 | | SwissProt: | A7UMX5_MELGA | | TrEMBL: | | | NCBI (GI): | 156186198 | | Source organism: | Meleagris gallopavo (Common turkey) | | Sequence length: | 996 | | Percent disordered: | 100% | | Homologues: | |
| Native sequence |
10 20 30 40 50 60
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MIQSAAPSIP RVEVILDCSD REKEAPKSLA ERGCVDSQVE GGQSEAPPSL PSFAISSEGT - 60
EQGEDNQHSE KDHRPLKHRA RHARLRRSES LSEKQVKEAK SKCKSIALLL TAAPNPNSKG - 120
VLMFKKRRQR ARKYTLVSYG TGELERDEDE GEEGEVEEGD KENTFEVSLL ATSESEIDED - 180
FFSDIDNDKK IVTFDWDSGL LEVEKKTKSG DEMQTLPETT GKGALMFARR RQRMDQITAE - 240
QEEMKARTAH AEEQREVTVS ENFQKVSSSA YQTKEEEMLR QQPCISKSYA DVSQNDGKIV - 300
QQNGFGVAPD TSLSFQSSEA QKAASLNRTA KPFPFGVQNR AAAPFSPTRN VTSPLSDLPA - 360
PPPYCSISPP PEALYRPLSA PAASKAAPIL WSHTEPTERI ASRDERIAVP AKRTGILQEA - 420
KRRSTSKPMF SFKEAPKVSP NPALLSLVHN AEGKKGSGAG FESGPEEDYL SLGAEACNFM - 480
QSQASKQKAP PPTAPKPSLK VSPAAGTPVS PVWSPAVASN KAPSFPAPAS PQAAYPAPLK - 540
SPQYPHSPSA NPPNTLNLSG PFKGPQATLA SPNHPAKTPT TPSAGETKPF EMPPEMRGKG - 600
AQLFARRHSR MEKYVVDSET VQANMARASS PTPSLPASWK YSSNVRAPPP VAYNPIHSPS - 660
YPPAATKPFP KSTAATKNTK RKPKKGLNAL DIMKHQPYQL DASLFTFQPP SNKESLGIKQ - 720
IPKLPTSKQA TSLRLPGSAS PTNVRASSVY SVPAYSSQPS FQSNASTPVN ESYTPTGYSA - 780
FSKPESTTSS LFTAPRPKFS AKKAGVIAQE RSSGRSLSLP GKPSFISRAT SPTSPLIFQP - 840
APDYFSKPDT AADKPGKRLT PWEAAAKSPL GLVDEAFRPQ NMQESIAANV VSAAHRKTLP - 900
EPPDEWKQKV SYEPPGPSAS LALLGGKQPG VTSARKSSLS VSNATTQAGS QQQYAYCSQR - 960
SQTDPDIMSM DSRSDYGLST ADSNYNPQPR GWRRPT
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| Functional narrative |
Fesselin is a member of the synaptopodin family of proteins. It may organize actin filaments in smooth muscle cells.
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| Map of ordered and disordered regions |
Note: 'Mouse' over a region to see the start and stop residues. Click on a region to see detailed information.
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| Region 1 | | Type: | Disordered | | Name: | | | Location: | 1 - 996 | | Length: | 996 | | Region sequence: |
MIQSAAPSIPRVEVILDCSDREKEAPKSLAERGCVDSQVEGGQSEAPPSLPSFAISSEGT
EQGEDNQHSEKDHRPLKHRARHARLRRSESLSEKQVKEAKSKCKSIALLLTAAPNPNSKG
VLMFKKRRQRARKYTLVSYGTGELERDEDEGEEGEVEEGDKENTFEVSLLATSESEIDED
FFSDIDNDKKIVTFDWDSGLLEVEKKTKSGDEMQTLPETTGKGALMFARRRQRMDQITAE
QEEMKARTAHAEEQREVTVSENFQKVSSSAYQTKEEEMLRQQPCISKSYADVSQNDGKIV
QQNGFGVAPDTSLSFQSSEAQKAASLNRTAKPFPFGVQNRAAAPFSPTRNVTSPLSDLPA
PPPYCSISPPPEALYRPLSAPAASKAAPILWSHTEPTERIASRDERIAVPAKRTGILQEA
KRRSTSKPMFSFKEAPKVSPNPALLSLVHNAEGKKGSGAGFESGPEEDYLSLGAEACNFM
QSQASKQKAPPPTAPKPSLKVSPAAGTPVSPVWSPAVASNKAPSFPAPASPQAAYPAPLK
SPQYPHSPSANPPNTLNLSGPFKGPQATLASPNHPAKTPTTPSAGETKPFEMPPEMRGKG
AQLFARRHSRMEKYVVDSETVQANMARASSPTPSLPASWKYSSNVRAPPPVAYNPIHSPS
YPPAATKPFPKSTAATKNTKRKPKKGLNALDIMKHQPYQLDASLFTFQPPSNKESLGIKQ
IPKLPTSKQATSLRLPGSASPTNVRASSVYSVPAYSSQPSFQSNASTPVNESYTPTGYSA
FSKPESTTSSLFTAPRPKFSAKKAGVIAQERSSGRSLSLPGKPSFISRATSPTSPLIFQP
APDYFSKPDTAADKPGKRLTPWEAAAKSPLGLVDEAFRPQNMQESIAANVVSAAHRKTLP
EPPDEWKQKVSYEPPGPSASLALLGGKQPGVTSARKSSLSVSNATTQAGSQQQYAYCSQR
SQTDPDIMSMDSRSDYGLSTADSNYNPQPRGWRRPT | | Modification type: | Native
| | PDB: | | | Structural/functional type: | Function arises from the disordered state
| | Functional classes: | | | Functional subclasses: | | Detection methods:
- Circular dichroism (CD) spectroscopy, far-UV
- Fluorescence, intrinsic
- Size exclusion/gel filtration chromatography
- Static light scattering
| References:
- Khaymina SS, Kenney JM, Schroeter MM, Chalovich JM. "Fesselin is a natively unfolded protein." J Proteome Res. 2007; 6(9): 3648-54. PubMed: 17676886
| Comments:
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| References |
- Khaymina SS, Kenney JM, Schroeter MM, Chalovich JM. "Fesselin is a natively unfolded protein." J Proteome Res. 2007; 6(9): 3648-54. PubMed: 17676886
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