| General information | | DisProt: | DP00537 | | Name: | Septin-4 [Isoform 1 (PNUTL2a)] | | Synonym(s): | SEPT4_HUMAN
Peanut-like protein 2
Brain protein H5
Cell division control-related protein 2
hCDCREL-2
Bradeion beta
CE5B3 beta
Cerebral protein 7
| | First appeared in release: | Release 3.7 (01/28/2008) | | UniProt: | O43236-1 | | UniGene: | Hs.287518 | | SwissProt: | SEPT4_HUMAN | | TrEMBL: | | | NCBI (GI): | 3287733 | | Source organism: | Homo sapiens (Human) | | Sequence length: | 478 | | Percent disordered: | 25% | | Homologues: | |
| Native sequence |
10 20 30 40 50 60
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MDRSLGWQGN SVPEDRTEAG IKRFLEDTTD DGELSKFVKD FSGNASCHPP EAKTWASRPQ - 60
VPEPRPQAPD LYDDDLEFRP PSRPQSSDNQ QYFCAPAPLS PSARPRSPWG KLDPYDSSED - 120
DKEYVGFATL PNQVHRKSVK KGFDFTLMVA GESGLGKSTL VNSLFLTDLY RDRKLLGAEE - 180
RIMQTVEITK HAVDIEEKGV RLRLTIVDTP GFGDAVNNTE CWKPVAEYID QQFEQYFRDE - 240
SGLNRKNIQD NRVHCCLYFI SPFGHGLRPL DVEFMKALHQ RVNIVPILAK ADTLTPPEVD - 300
HKKRKIREEI EHFGIKIYQF PDCDSDEDED FKLQDQALKE SIPFAVIGSN TVVEARGRRV - 360
RGRLYPWGIV EVENPGHCDF VKLRTMLVRT HMQDLKDVTR ETHYENYRAQ CIQSMTRLVV - 420
KERNRNKLTR ESGTDFPIPA VPPGTDPETE KLIREKDEEL RRMQEMLHKI QKQMKENY
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| Functional narrative |
Septins are a conserved family of guanosine-5'-triphosphate (GTP)-binding proteins. In mammals they are involved in a variety of cellular processes, such as cytokinesis, exocytosis, and vesicle trafficking. SEPT4 has also been shown to be expressed in both human colorectal cancer and malignant melanoma, as well as being involved in neurodegenerative disorders. Filament-forming cytoskeletal GTPase. May play a role in cytokinesis Potential. May play a role in platelet secretion.
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| Map of ordered and disordered regions |
Note: 'Mouse' over a region to see the start and stop residues. Click on a region to see detailed information.
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| Region 1 | | Type: | Disordered | | Name: | | | Location: | 1 - 119 | | Length: | 119 | | Region sequence: |
MDRSLGWQGNSVPEDRTEAGIKRFLEDTTDDGELSKFVKDFSGNASCHPPEAKTWASRPQ
VPEPRPQAPDLYDDDLEFRPPSRPQSSDNQQYFCAPAPLSPSARPRSPWGKLDPYDSSE | | Modification type: | Native
| | PDB: | | | Structural/functional type: | | | Functional classes: | | | Functional subclasses: | | Detection methods:
- Dynamic light scattering
- Small-angle X-ray scattering (SAXS)
- Circular dichroism (CD) spectroscopy, far-UV
| References:
- Garcia W, de Araújo AP, Neto Mde O, Ballestero MR, Polikarpov I, Tanaka M, Tanaka T, Garratt RC. "Dissection of a human septin: definition and characterization of distinct domains within human SEPT4." Biochemistry. 2006; 45(46): 13918-31. PubMed: 17105210
| Comments:
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| References |
- Garcia W, de Araújo AP, Neto Mde O, Ballestero MR, Polikarpov I, Tanaka M, Tanaka T, Garratt RC. "Dissection of a human septin: definition and characterization of distinct domains within human SEPT4." Biochemistry. 2006; 45(46): 13918-31. PubMed: 17105210
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