DP00540: DribbleFASTA viewXML view

General information
DisProt:DP00540
Name:Dribble
Synonym(s):Q9VPU8_DROME
LD24634p
CG4258-PA
First appeared in release:Release 3.7 (01/28/2008)
UniProt:Q9VPU8
UniGene:Dm.2087
SwissProt: Q9VPU8_DROME
TrEMBL:  
NCBI (GI): 74870304
Source organism:Drosophila melanogaster (Fruit fly)
Sequence length:345
Percent disordered:100%
Homologues: 


Native sequence

        10         20         30         40         50         60
         |          |          |          |          |          |
MSESEAEETK ISTEPVDNAW SMKIPAFRQE DNPHGMVEES SFATLFPKYR ERYLKEVWPL - 60
VEQCLAEHHL KAELDLMEGS MVVKTSRKTW DPYIIIKARD MIKLMARSVP FEQAKRVLQD - 120
DIGCDIIKIG NLVHKKEKFV KRRQRLIGPN GATLKSIELL TDCYVLVQGN TVSALGPYKG - 180
LQQVRDIVLE TMNNVHPIYN IKALMIKREL MKDPRLANED WSRFLPKFKN KNISKRKQPK - 240
VKKQKKEYTP FPPSQPESKV DKQLASGEYF LNQEQKQAKR NQERTEKQKE AAKRQDERRN - 300
KDFVPPTEES AASSRKKEDG SSSSKVDVKA LKAKLIKANK KARSS



Functional narrative    

Dribble (DBE) is an essential protein in Drosophila that belongs to the evolutionarily conserved Krr1p protein family. Proteins in this family are localised in the cell nucleolus and are important for the processing of ribosomal RNAs.

Region 1: 1-345

Map of ordered and disordered regions







Note: 'Mouse' over a region to see the start and stop residues. Click on a region to see detailed information.


Region 1
Type:Disordered
Name: 
Location:1 - 345
Length:345
Region sequence:

MSESEAEETKISTEPVDNAWSMKIPAFRQEDNPHGMVEESSFATLFPKYRERYLKEVWPL
VEQCLAEHHLKAELDLMEGSMVVKTSRKTWDPYIIIKARDMIKLMARSVPFEQAKRVLQD
DIGCDIIKIGNLVHKKEKFVKRRQRLIGPNGATLKSIELLTDCYVLVQGNTVSALGPYKG
LQQVRDIVLETMNNVHPIYNIKALMIKRELMKDPRLANEDWSRFLPKFKNKNISKRKQPK
VKKQKKEYTPFPPSQPESKVDKQLASGEYFLNQEQKQAKRNQERTEKQKEAAKRQDERRN
KDFVPPTEESAASSRKKEDGSSSSKVDVKALKAKLIKANKKARSS

Modification type: Native
PDB:  
Structural/functional type: Function arises from the disordered state
Functional classes:  
Functional subclasses: Protein-rRNA binding
Detection methods:
  1. Sensitivity to proteolysis (295 K; )

  2. Circular dichroism (CD) spectroscopy, far-UV (pH: 7.4; K2HPO4 50 mM)

  3. Fluorescence, intrinsic (295 K; pH: 7.4; K2HPO4 50 mM)

  4. Size exclusion/gel filtration chromatography (pH: 7.4; K2HPO4 50 mM; NaCl 200 mM)

  5. Analytical ultracentrifugation (277 K; pH: 7.4; K2HPO4 50 mM; NaCl 200 mM)

References:
  1. Yiu CP, Beavil RL, Chan HY. "Biophysical characterisation reveals structural disorder in the nucleolar protein, Dribble." Biochem Biophys Res Commun. 2006; 343(1): 311-8. PubMed: 16542639

Comments:
 



References

  1. Yiu CP, Beavil RL, Chan HY. "Biophysical characterisation reveals structural disorder in the nucleolar protein, Dribble." Biochem Biophys Res Commun. 2006; 343(1): 311-8. PubMed: 16542639


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