| General information | | DisProt: | DP00540 | | Name: | Dribble | | Synonym(s): | Q9VPU8_DROME
LD24634p
CG4258-PA
| | First appeared in release: | Release 3.7 (01/28/2008) | | UniProt: | Q9VPU8 | | UniGene: | Dm.2087 | | SwissProt: | Q9VPU8_DROME | | TrEMBL: | | | NCBI (GI): | 74870304 | | Source organism: | Drosophila melanogaster (Fruit fly) | | Sequence length: | 345 | | Percent disordered: | 100% | | Homologues: | |
| Native sequence |
10 20 30 40 50 60
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MSESEAEETK ISTEPVDNAW SMKIPAFRQE DNPHGMVEES SFATLFPKYR ERYLKEVWPL - 60
VEQCLAEHHL KAELDLMEGS MVVKTSRKTW DPYIIIKARD MIKLMARSVP FEQAKRVLQD - 120
DIGCDIIKIG NLVHKKEKFV KRRQRLIGPN GATLKSIELL TDCYVLVQGN TVSALGPYKG - 180
LQQVRDIVLE TMNNVHPIYN IKALMIKREL MKDPRLANED WSRFLPKFKN KNISKRKQPK - 240
VKKQKKEYTP FPPSQPESKV DKQLASGEYF LNQEQKQAKR NQERTEKQKE AAKRQDERRN - 300
KDFVPPTEES AASSRKKEDG SSSSKVDVKA LKAKLIKANK KARSS
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| Functional narrative |
Dribble (DBE) is an essential protein in Drosophila that belongs to the evolutionarily conserved Krr1p protein family. Proteins in this
family are localised in the cell nucleolus and are important for the processing of ribosomal RNAs.
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| Map of ordered and disordered regions |
Note: 'Mouse' over a region to see the start and stop residues. Click on a region to see detailed information.
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| Region 1 | | Type: | Disordered | | Name: | | | Location: | 1 - 345 | | Length: | 345 | | Region sequence: |
MSESEAEETKISTEPVDNAWSMKIPAFRQEDNPHGMVEESSFATLFPKYRERYLKEVWPL
VEQCLAEHHLKAELDLMEGSMVVKTSRKTWDPYIIIKARDMIKLMARSVPFEQAKRVLQD
DIGCDIIKIGNLVHKKEKFVKRRQRLIGPNGATLKSIELLTDCYVLVQGNTVSALGPYKG
LQQVRDIVLETMNNVHPIYNIKALMIKRELMKDPRLANEDWSRFLPKFKNKNISKRKQPK
VKKQKKEYTPFPPSQPESKVDKQLASGEYFLNQEQKQAKRNQERTEKQKEAAKRQDERRN
KDFVPPTEESAASSRKKEDGSSSSKVDVKALKAKLIKANKKARSS | | Modification type: | Native
| | PDB: | | | Structural/functional type: | Function arises from the disordered state
| | Functional classes: | | | Functional subclasses: | Protein-rRNA binding
| Detection methods:
- Sensitivity to proteolysis (295 K; )
- Circular dichroism (CD) spectroscopy, far-UV (pH: 7.4; K2HPO4 50 mM)
- Fluorescence, intrinsic (295 K; pH: 7.4; K2HPO4 50 mM)
- Size exclusion/gel filtration chromatography (pH: 7.4; K2HPO4 50 mM; NaCl 200 mM)
- Analytical ultracentrifugation (277 K; pH: 7.4; K2HPO4 50 mM; NaCl 200 mM)
| References:
- Yiu CP, Beavil RL, Chan HY. "Biophysical characterisation reveals structural disorder in the nucleolar protein, Dribble." Biochem Biophys Res Commun. 2006; 343(1): 311-8. PubMed: 16542639
| Comments:
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| References |
- Yiu CP, Beavil RL, Chan HY. "Biophysical characterisation reveals structural disorder in the nucleolar protein, Dribble." Biochem Biophys Res Commun. 2006; 343(1): 311-8. PubMed: 16542639
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