| General information | | DisProt: | DP00543 | | Name: | Cytochrome c oxidase copper chaperone | | Synonym(s): | COX17_HUMAN
Cox17
| | First appeared in release: | Release 3.8 (05/27/2008) | | UniProt: | Q14061 | | UniGene: | Hs.534383 | | SwissProt: | COX17_HUMAN | | TrEMBL: | | | NCBI (GI): | 2493873 | | Source organism: | Homo sapiens (Human) | | Sequence length: | 63 | | Percent disordered: | 27% | | Homologues: | |
| Native sequence |
10 20 30 40 50 60
| | | | | |
MPGLVDSNPA PPESQEKKPL KPCCACPETK KARDACIIEK GEEHCGHLIE AHKECMRALG - 60
FKI
|
| Functional narrative |
Human Cox17 is a key mitochondrial copper chaperone responsible of supplying copper ions, through the assistance of Sco1, Sco2 and Cox11, to cytochrome c oxidase (CcO), the terminal enzyme of the mitochondrial energy transducing respiratory chain. Copper chaperone for cytochrome c oxidase (COX). Binds two copper ions and deliver them to the Cu(A) site of COX.
|
| Map of ordered and disordered regions |
Note: 'Mouse' over a region to see the start and stop residues. Click on a region to see detailed information.
|
| Region 1 | | Type: | Disordered | | Name: | N-terminal tail | | Location: | 1 - 17 | | Length: | 17 | | Region sequence: |
MPGLVDSNPAPPESQEK | | Modification type: | Native
| | PDB: | | | Structural/functional type: | Relationship to function unknown
| | Functional classes: | Chaperones
| | Functional subclasses: | Metal binding
| Detection methods:
- Circular dichroism (CD) spectroscopy, far-UV (298 K; pH: 7.2; DTT; phosphate (buffer) 10 mM; protein (sample) 15 μM)
- Nuclear magnetic resonance (NMR) (298 K; pH: 7.2; 13C,15N labeled HCox17 0.5 mM; D2O 10 %; DTT 1 mM; phosphate (buffer) 50 mM)
| References:
- Banci L, Bertini I, Ciofi-Baffoni S, Janicka A, Martinelli M, Kozlowski H, Palumaa P. "A structural-dynamical characterization of human Cox17." J Biol Chem. 2008; 283(12): 7912-20. PubMed: 18093982
| Comments:
|
| References |
- Voronova A, Meyer-Klaucke W, Meyer T, Rompel A, Krebs B, Kazantseva J, Sillard R, Palumaa P. "Oxidative switches in functioning of mammalian copper chaperone Cox17." Biochem J. 2007; 408(1): 139-48. PubMed: 17672825
|
| If you have any comments or wish to provide additional references to this protein or its disordered region(s), please click here to e-mail us. |
Disprot-footer
|
