| General information | | DisProt: | DP00544 | | Name: | Protein LLP | | Synonym(s): | LLPH_APLKU
Protein LAPS18-like
| | First appeared in release: | Release 3.8 (05/27/2008) | | UniProt: | B0FRH7 | | UniGene: | | | SwissProt: | LLPH_APLKU | | TrEMBL: | | | NCBI (GI): | 224493107 | | Source organism: | Aplysia kurodai (Kuroda's sea hare) | | Sequence length: | 120 | | Percent disordered: | 100% | | Homologues: | |
| Native sequence |
10 20 30 40 50 60
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MAKSIRSKHR RQMRNVKREH FAKKDLDRLK RLASKAQELD LDNVVTMKSA EEIKNKPSTS - 60
ASDADKGMEV DNTKKVFKKK TQQNEDGHYP QWMNQRAVKK QKVKVAKLKT KKKIGKKIKW - 120
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| Functional narrative |
Protein LLP was identified to be a transcription factor which induces the ApC/EBP expression required for long-term synaptic facilitation in Aplysis neurons. It is an activity-dependent transcriptional activator that is critically involved in long-term facilitation (LTF) and behavioral sensitization by inducing ApC/EBP expression. Acts as a transcriptional activator of C/EBP. Required for long-term synaptic facilitation at the sensory motor synapse. May function in noxious stimulus-facilitated memory formation.
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| Map of ordered and disordered regions |
Note: 'Mouse' over a region to see the start and stop residues. Click on a region to see detailed information.
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| Region 1 | | Type: | Disordered | | Name: | | | Location: | 1 - 120 | | Length: | 120 | | Region sequence: |
MAKSIRSKHRRQMRNVKREHFAKKDLDRLKRLASKAQELDLDNVVTMKSAEEIKNKPSTS
ASDADKGMEVDNTKKVFKKKTQQNEDGHYPQWMNQRAVKKQKVKVAKLKTKKKIGKKIKW
| | Modification type: | Native
| | PDB: | | | Structural/functional type: | Function arises from the disordered state
| | Functional classes: | | | Functional subclasses: | Transactivation (transcriptional activation)
Protein-DNA binding
| Detection methods:
- Circular dichroism (CD) spectroscopy, far-UV (298 K; pH: 3.8; protein (sample) 15 microM; pure water)
- Circular dichroism (CD) spectroscopy, near-UV (298 K; pH: 3.8; protein (sample) 15 microM; pure water; urea 8M or 0 M)
- Nuclear magnetic resonance (NMR) (298 K; pH: 3.8; D2O 10 %; protein (sample) 0.2 mM; pure water)
| References:
- Liu J, Song J. "A novel nucleolar transcriptional activator ApLLP for long-term memory formation is intrinsically unstructured but functionally active." Biochem Biophys Res Commun. 2008; 366(2): 585-91. PubMed: 18078811
| Comments:
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| References |
- Kim H, Lee SH, Han JH, Lee JA, Cheang YH, Chang DJ, Lee YS, Kaang BK. "A nucleolar protein ApLLP induces ApC/EBP expression required for long-term synaptic facilitation in aplysia neurons." Neuron. 2006; 49(5): 707-18. PubMed: 16504946
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