| General information | | DisProt: | DP00549 | | Name: | Zinc finger protein 593 | | Synonym(s): | ZN593_HUMAN
ZNF593
Zinc finger protein T86
| | First appeared in release: | Release 6.00 (07/01/2012) | | UniProt: | O00488 | | UniGene: | Hs.477273 | | SwissProt: | ZN593_HUMAN | | TrEMBL: | | | NCBI (GI): | 254763379 | | Source organism: | Homo sapiens (Human) | | Sequence length: | 134 | | Percent disordered: | 75% | | Homologues: | |
| Native sequence |
10 20 30 40 50 60
| | | | | |
MGRSRRTGAH RAHSLARQMK AKRRRPDLDE IHRELRPQGS ARPQPDPNAE FDPDLPGGGL - 60
HRCLACARYF IDSTNLKTHF RSKDHKKRLK QLSVEPYSQE EAERAAGMGS YVPPRRLAVP - 120
TEVSTEVPEM DTST
|
| Functional narrative |
Negatively modulates the DNA binding activity of Oct-2 and therefore its transcriptional regulatory activity. Could act either by binding to DNA octamer or by interacting with Oct-2. May also be a modulator of other octamer-binding proteins.
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| Map of ordered and disordered regions |
Note: 'Mouse' over a region to see the start and stop residues. Click on a region to see detailed information.
|
| Region 1 | | Type: | Disordered | | Name: | N-terminal | | Location: | 1 - 60 | | Length: | 60 | | Region sequence: |
MGRSRRTGAHRAHSLARQMKAKRRRPDLDEIHRELRPQGSARPQPDPNAEFDPDLPGGGL
| | Modification type: | Complex
| | PDB: | 1ZR9:A | | Structural/functional type: | Function arises from the disordered state
| | Functional classes: | Molecular recognition effectors
| | Functional subclasses: | Substrate/ligand binding
| Detection methods:
- Nuclear magnetic resonance (NMR) (298 K; pH: 6; 90% H2O, 10% D2O (solvent system); Bis Tris 10 mM; DTT 2 mM; NaCl 100 mM; ZNF593 protein (in presence of Zn2+) 0.6 mM)
| References:
- Hayes PL, Lytle BL, Volkman BF, Peterson FC. "The solution structure of ZNF593 from Homo sapiens reveals a zinc finger in a predominately unstructured protein." Protein Sci. 2008; 17(3): 571-6. PubMed: 18287285
| Comments:
|
| Region 2 | | Type: | Ordered | | Name: | Zinc-finger motif | | Location: | 61 - 93 | | Length: | 33 | | Region sequence: |
HRCLACARYFIDSTNLKTHFRSKDHKKRLKQLS | | Modification type: | Complex
| | PDB: | 1ZR9:A | | Structural/functional type: | Function arises from the ordered state
| | Functional classes: | Molecular recognition effectors
| | Functional subclasses: | Substrate/ligand binding
| Detection methods:
- Nuclear magnetic resonance (NMR) (298 K; 90% H2O, 10% D2O (solvent system); Bis Tris 10 mM; DTT 2 mM; NaCl 100 mM; ZNF593 protein (in presence of Zn2+) 0.6 mM)
| References:
- Hayes PL, Lytle BL, Volkman BF, Peterson FC. "The solution structure of ZNF593 from Homo sapiens reveals a zinc finger in a predominately unstructured protein." Protein Sci. 2008; 17(3): 571-6. PubMed: 18287285
| Comments:Region 2 contains the four residues involved in binding zinc ion: aa C63, C66, H79 and H85.
|
| Region 3 | | Type: | Disordered | | Name: | C-terminal | | Location: | 94 - 134 | | Length: | 41 | | Region sequence: |
VEPYSQEEAERAAGMGSYVPPRRLAVPTEVSTEVPEMDTST | | Modification type: | Complex
| | PDB: | 1ZR9:A | | Structural/functional type: | Function arises from the disordered state
| | Functional classes: | Molecular recognition effectors
| | Functional subclasses: | Substrate/ligand binding
| Detection methods:
- Nuclear magnetic resonance (NMR) (298 K; pH: 6; 90% H2O, 10% D2O (solvent system); Bis Tris 10 mM; DTT 2 mM; NaCl 100 mM; ZNF593 protein (in presence of Zn2+) 0.6 mM)
| References:
- Hayes PL, Lytle BL, Volkman BF, Peterson FC. "The solution structure of ZNF593 from Homo sapiens reveals a zinc finger in a predominately unstructured protein." Protein Sci. 2008; 17(3): 571-6. PubMed: 18287285
| Comments:
|
| References |
- Hayes PL, Lytle BL, Volkman BF, Peterson FC. "The solution structure of ZNF593 from Homo sapiens reveals a zinc finger in a predominately unstructured protein." Protein Sci. 2008; 17(3): 571-6. PubMed: 18287285
|
| Comments |
AV sent 10/1/2012 (PMID 18287285)
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| If you have any comments or wish to provide additional references to this protein or its disordered region(s), please click here to e-mail us. |
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