| General information | | DisProt: | DP00552 | | Name: | Sigma-E factor negative regulatory protein | | Synonym(s): | RSEA_ECOLI
RseA
| | First appeared in release: | Release 3.8 (05/27/2008) | | UniProt: | P0AFX7 | | UniGene: | | | SwissProt: | RSEA_ECOLI | | TrEMBL: | | | NCBI (GI): | 84028312 | | Source organism: | Escherichia coli | | Sequence length: | 216 | | Percent disordered: | 44% | | Homologues: | |
| Native sequence |
10 20 30 40 50 60
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MQKEQLSALM DGETLDSELL NELAHNPEMQ KTWESYHLIR DSMRGDTPEV LHFDISSRVM - 60
AAIEEEPVRQ PATLIPEAQP APHQWQKMPF WQKVRPWAAQ LTQMGVAACV SLAVIVGVQH - 120
YNGQSETSQQ PETPVFNTLP MMGKASPVSL GVPSEATANN GQQQQVQEQR RRINAMLQDY - 180
ELQRRLHSEQ LQFEQAQTQQ AAVQVPGIQT LGTQSQ
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| Functional narrative |
The bacterial envelope stress response is modulated by the binding of RseB to RseA. Various stress signals are transduced into the cytoplasmic compartment through the periplasmic membrane and thus activate the genes required for the defense or recovery of the cells against the stress. The periplasmic domain of RseA is cleaved by the activated DegS in stress conditions and the cytoplasmic domain of RseA is digested by RseP. This sequential digestion of RseA results in the release of sigmaE, which ultimately enhances the transcription of the gene involved in stress response. Negative regulator of rpoE.
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| Map of ordered and disordered regions |
Note: 'Mouse' over a region to see the start and stop residues. Click on a region to see detailed information.
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| Region 1 | | Type: | Disordered | | Name: | periplasmic domain | | Location: | 121 - 216 | | Length: | 96 | | Region sequence: |
YNGQSETSQQPETPVFNTLPMMGKASPVSLGVPSEATANNGQQQQVQEQRRRINAMLQDY
ELQRRLHSEQLQFEQAQTQQAAVQVPGIQTLGTQSQ | | Modification type: | Fragment
| | PDB: | | | Structural/functional type: | | | Functional classes: | Molecular assembly
| | Functional subclasses: | Regulation of proteolysis in vivo
Protein-protein binding
| Detection methods:
- Circular dichroism (CD) spectroscopy, far-UV
- Small-angle X-ray scattering (SAXS)
| References:
- Jin KS, Kim DY, Rho Y, Le VB, Kwon E, Kim KK, Ree M. "Solution structures of RseA and its complex with RseB." J Synchrotron Radiat. 2008; 15(3): 219-222. PubMed: 18421143
| Comments:
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