General information | DisProt: | DP00560_C007 | Name: | Viral genome-linked protein [cleavage product 7] | Synonym(s): | POLG_TUMVQ
VPg
cleavage product 7 of Genome polyprotein
| First appeared in release: | Release 4.0 (06/23/2008) | UniProt: | Q02597 | UniGene: | | SwissProt: | POLG_TUMVQ | TrEMBL: | | NCBI (GI): | 548557 | Source organism: | Turnip mosaic virus | Sequence length: | 192 | Percent disordered: | 100% | Homologues: | |
Native sequence |
10 20 30 40 50 60 | | | | | | AKGKKQRQKL KFRNARDNKM GREVYGDDDT IEHFFGDAYT KKGKSKGRTR GIGHKNRKFI - 60 NMYGFDPEDF SAVRFVDPLT GATLDDNPFT DITLVQKHFG DIRMDLLGED ELDSNEIRMN - 120 KTIQAYYMNN KTGKALKVDL TPHIPLKVCD LHATIAGFPE RENELRQTGK AQPINIDEVP - 180 RANNELVPVD HE
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Functional narrative |
Coat protein is involved in aphid transmission, cell-to-cell and systemis movement, encapsidation of the viral RNA and in the regulation of viral RNA amplification. Nuclear inclusion protein B is a RNA-dependent RNA polymerase that plays an essential role in the virus replication. Helper component proteinase is required for aphid transmission and also has proteolytic activity. Interacts with virions and aphid stylets. Acts as a suppressor of RNA-mediated gene silencing, also known as post-transcriptional gene silencing (PTGS), a mechanism of plant viral defense that limits the accumulation of viral RNAs. May have RNA-binding activity. Cytoplasmic inclusion protein has helicase activity. It may be involved in replication. Both 6K peptides are indispensable for virus replication. Nuclear inclusion protein A has RNA-binding and proteolytic activities. Viral genome-linked protein is cleavage product 7 of Genome polyprotein, comprising aa1924-2115 of the polyprotein.
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Map of ordered and disordered regions |
Note: 'Mouse' over a region to see the start and stop residues. Click on a region to see detailed information.
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Region 1 | Type: | Disordered | Name: | VPg | Location: | 1 - 192 | Length: | 192 | Region sequence: |
AKGKKQRQKLKFRNARDNKMGREVYGDDDTIEHFFGDAYTKKGKSKGRTRGIGHKNRKFI NMYGFDPEDFSAVRFVDPLTGATLDDNPFTDITLVQKHFGDIRMDLLGEDELDSNEIRMN KTIQAYYMNNKTGKALKVDLTPHIPLKVCDLHATIAGFPERENELRQTGKAQPINIDEVP RANNELVPVDHE | Modification type: | Native
| PDB: | | Structural/functional type: | Relationship to function unknown | Functional classes: | Unknown
| Functional subclasses: | Unknown
| Detection methods: | References:
- Grzela R, Szolajska E, Ebel C, Madern D, Favier A, Wojtal I, Zagorski W, Chroboczek J. "Virulence factor of potato virus Y, genome-attached terminal protein VPg, is a highly disordered protein." J Biol Chem. 2008; 283(1): 213-21. PubMed: 17971447
- Nicolas O, Laliberté JF. "The complete nucleotide sequence of turnip mosaic potyvirus RNA." J Gen Virol. 1992; 73(11): 2785-93. PubMed: 1431807
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Comments |
Previous entry DP00560 has been split into polyprotein (DP00560) and cleavage product (DP00560_C007).
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