| General information | | DisProt: | DP00563 | | Name: | Bcl2 antagonist of cell death | | Synonym(s): | BAD_MOUSE
BAD
Bcl-2-binding component 6
Bcl-xL/Bcl-2-associated death promoter
| | First appeared in release: | Release 4.0 (06/23/2008) | | UniProt: | Q61337 | | UniGene: | Mm.4387 | | SwissProt: | BAD_MOUSE | | TrEMBL: | | | NCBI (GI): | 2493288 | | Source organism: | Mus musculus (Mouse) | | Sequence length: | 204 | | Percent disordered: | 100% | | Homologues: | |
| Native sequence |
10 20 30 40 50 60
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MGTPKQPSLA PAHALGLRKS DPGIRSLGSD AGGRRWRPAA QSMFQIPEFE PSEQEDASAT - 60
DRGLGPSLTE DQPGPYLAPG LLGSNIHQQG RAATNSHHGG AGAMETRSRH SSYPAGTEED - 120
EGMEEELSPF RGRSRSAPPN LWAAQRYGRE LRRMSDEFEG SFKGLPRPKS AGTATQMRQS - 180
AGWTRIIQSW WDRNLGKGGS TPSQ
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| Functional narrative |
BH3 protein which plays an important role in the initiation of apoptosis. Predicted to be disordered when not bound to one of its prosurvival proteins. Promotes cell death. Successfully competes for the binding to Bcl-X(L), Bcl-2 and Bcl-W, thereby affecting the level of heterodimerization of these proteins with BAX. Can reverse the death repressor activity of Bcl-X(L), but not that of Bcl-2. Appears to act as a link between growth factor receptor signaling and the apoptotic pathways.
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| Map of ordered and disordered regions |
Note: 'Mouse' over a region to see the start and stop residues. Click on a region to see detailed information.
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| Region 1 | | Type: | Disordered | | Name: | | | Location: | 1 - 204 | | Length: | 204 | | Region sequence: |
MGTPKQPSLAPAHALGLRKSDPGIRSLGSDAGGRRWRPAAQSMFQIPEFEPSEQEDASAT
DRGLGPSLTEDQPGPYLAPGLLGSNIHQQGRAATNSHHGGAGAMETRSRHSSYPAGTEED
EGMEEELSPFRGRSRSAPPNLWAAQRYGRELRRMSDEFEGSFKGLPRPKSAGTATQMRQS
AGWTRIIQSWWDRNLGKGGSTPSQ | | Modification type: | Native
| | PDB: | 2BZW:A | | Structural/functional type: | Function arises via a disorder to order transition
| | Functional classes: | Modification site
| | Functional subclasses: | Apoptosis Regulation
Protein-protein binding
| Detection methods:
| References:
There are no documents referencing this region. | Comments:
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| References |
- Hinds MG, Smits C, Fredericks-Short R, Risk JM, Bailey M, Huang DC, Day CL. "Bim, Bad and Bmf: intrinsically unstructured BH3-only proteins that undergo a localized conformational change upon binding to prosurvival Bcl-2 targets." Cell Death Differ. 2006. PubMed: 16645638
- Petros AM, Nettesheim DG, Wang Y, Olejniczak ET, Meadows RP, Mack J, Swift K, Matayoshi ED, Zhang H, Thompson CB, Fesik SW. "Rationale for Bcl-xL/Bad peptide complex formation from structure, mutagenesis, and biophysical studies." Protein Sci. 2000; 9(12): 2528-34. PubMed: 11206074
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