| General information | | DisProt: | DP00566 | | Name: | Hemagglutinin | | Synonym(s): | HEMA_I84A2
Hemagglutinin HA1 chain [cleavage product 1]
Hemagglutinin HA2 chain [cleavage product 2]
| | First appeared in release: | Release 4.1 (07/10/2008) | | UniProt: | P13102 | | UniGene: | | | SwissProt: | HEMA_I84A2 | | TrEMBL: | | | NCBI (GI): | 122923 | | Source organism: | Influenza A virus | | Sequence length: | 566 | | Percent disordered: | 6% | | Homologues: | |
| Native sequence |
10 20 30 40 50 60
| | | | | |
MDIRPIIISL LISTCVQADR ICVGYLSTNS TEKVDTLLEN DVPVTSSIDL VETNHTGTYC - 60
SLDGISPVHL GDCSFEGWIV GNPACTSNFG IREWSYLIED PSAPHGLCYP GELDNNGELR - 120
HLFSGIRSFS RTELIAPTSW GEVNDGATSA CRDNTGTNSF YRNLVWFVKK GNSYPVISRT - 180
YNNTTGRDVL VMWGLHHPVS TDETKSLYVN SDPYTLVSTS SWSKKYKLET GVRPGYNGQR - 240
SWMKIYWVLM HPGESITFES NGGLLAPRYG YIIEEYGKGR IFQSPIRIAR CNTRCQTSVG - 300
GINTNKTFQN IERNALGNCP KYIKSGQLKL ATGLRNVPAI SNRGLFGAIA GFIEGGWPGL - 360
INGWYGFQHQ NEQGVGIAAD KESTQKAIDQ ITTKINNIID KMNGNYDSIR GEFSQVEQRI - 420
NMLADRIDDA VTDVWSYNAK LLVLLENDKT LDMHDANVRN LHEQVRRTLK ANAIDEGNGC - 480
FELLHKCNDS CMDTIRNGTY NHAEYAEESK LKRQEIEGIK LKSEDNVYKA LSIYSCIASS - 540
VVLVGLILAF IMWACSSGNC RFNVCI
|
| Functional narrative |
Binds to sialic acid-containing receptors on the cell surface, bringing about the attachment of the virus particle to the cell. Plays a major role in the determination of host range restriction and virulence. Class I viral fusion protein. Responsible for penetration of the virus into the cell cytoplasm by mediating the fusion of the membrane of the endocytosed virus particle with the endosomal membrane. Low pH in endosomes induce an irreversible conformational change in HA2, releasing the fusion hydrophobic peptide. Several trimers are required to form a competent fusion pore.
|
| Map of ordered and disordered regions |
Note: 'Mouse' over a region to see the start and stop residues. Click on a region to see detailed information.
|
| Region 1 | | Type: | Disordered | | Name: | | | Location: | 171 - 175 | | Length: | 5 | | Region sequence: |
GNSYP | | Modification type: | Native
| | PDB: | 1HTM:A | | Structural/functional type: | Function arises via a disorder to order transition
| | Functional classes: | Modification site
| | Functional subclasses: | Disordered region is not essential for protein function
| Detection methods:
| References:
- Bullough PA, Hughson FM, Skehel JJ, Wiley DC. "Structure of influenza haemagglutinin at the pH of membrane fusion." Nature. 1994; 371(6492): 37-43. PubMed: 8072525
| Comments:
|
| Region 2 | | Type: | Disordered | | Name: | | | Location: | 141 - 175 | | Length: | 35 | | Region sequence: |
GEVNDGATSACRDNTGTNSFYRNLVWFVKKGNSYP | | Modification type: | Native
| | PDB: | 1HTM:A | | Structural/functional type: | Function arises via a disorder to order transition
| | Functional classes: | Modification site
| | Functional subclasses: | Flexible linkers/spacers
| Detection methods:
| References:
- Bullough PA, Hughson FM, Skehel JJ, Wiley DC. "Structure of influenza haemagglutinin at the pH of membrane fusion." Nature. 1994; 371(6492): 37-43. PubMed: 8072525
| Comments:
|
| References |
- Chambers TM, Yamnikova S, Kawaoka Y, Lvov DK, Webster RG. "Antigenic and molecular characterization of subtype H13 hemagglutinin of influenza virus." Virology. 1989; 172(1): 180-8. PubMed: 2773315
|
| Comments |
Disorder is found in the Hemagglutinin HA1 chain (residues 19 - 342). A separate entry may be required for this cleavage product.
|
| If you have any comments or wish to provide additional references to this protein or its disordered region(s), please click here to e-mail us. |
Disprot-footer
|
