Annotation for this protein is in progress - please check future releases for more complete information


DP00568: Paired box 6FASTA viewXML view

General information
DisProt:DP00568
Name:Paired box 6
Synonym(s):Q66SS1_HUMAN
Paired box gene 6 isoform a
First appeared in release:Release 4.1 (07/10/2008)
UniProt:Q66SS1
UniGene:Hs.270303
SwissProt: Q66SS1_HUMAN
TrEMBL:  
NCBI (GI): 4505615
Source organism:Homo sapiens (Human)
Sequence length:422
Percent disordered:4%
Homologues: 


Native sequence

        10         20         30         40         50         60
         |          |          |          |          |          |
MQNSHSGVNQ LGGVFVNGRP LPDSTRQKIV ELAHSGARPC DISRILQVSN GCVSKILGRY - 60
YETGSIRPRA IGGSKPRVAT PEVVSKIAQY KRECPSIFAW EIRDRLLSEG VCTNDNIPSV - 120
SSINRVLRNL ASEKQQMGAD GMYDKLRMLN GQTGSWGTRP GWYPGTSVPG QPTQDGCQQQ - 180
EGGGENTNSI SSNGEDSDEA QMRLQLKRKL QRNRTSFTQE QIEALEKEFE RTHYPDVFAR - 240
ERLAAKIDLP EARIQVWFSN RRAKWRREEK LRNQRRQASN TPSHIPISSS FSTSVYQPIP - 300
QPTTPVSSFT SGSMLGRTDT ALTNTYSALP PMPSFTMANN LPMQPPVPSQ TSSYSCMLPT - 360
SPSVNGRSYD TYTPPHMQTH MNSQPMGTSG TTSTGLISPG VSVPVQVPGS EPDMSQYWPR - 420
LQ

Region 1: 64-79

Map of ordered and disordered regions







Note: 'Mouse' over a region to see the start and stop residues. Click on a region to see detailed information.


Region 1
Type:Disordered
Name: 
Location:64 - 79
Length:16
Region sequence:

GSIRPRAIGGSKPRVA

Modification type: Native
PDB:  
Structural/functional type: Function arises via a disorder to order transition
Functional classes: Modification site
Molecular assembly
Functional subclasses: Flexible linkers/spacers
Protein-DNA binding
Protein-protein binding
Detection methods:
 
References:
  1. Xu HE, Rould MA, Xu W, Epstein JA, Maas RL, Pabo CO. "Crystal structure of the human Pax6 paired domain-DNA complex reveals specific roles for the linker region and carboxy-terminal subdomain in DNA binding." Genes Dev. 1999; 13(10): 1263-75. PubMed: 10346815
Comments:
 



References

  1. Xu HE, Rould MA, Xu W, Epstein JA, Maas RL, Pabo CO. "Crystal structure of the human Pax6 paired domain-DNA complex reveals specific roles for the linker region and carboxy-terminal subdomain in DNA binding." Genes Dev. 1999; 13(10): 1263-75. PubMed: 10346815



Comments


Additional UniGene IDs: Hs.502235, Hs.611376


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