| General information | | DisProt: | DP00573_C003 | | Name: | Protein VP4 [cleavage product 3] | | Synonym(s): | POLG_FMDVO
Virion protein 4
P1A
cleavage product 3 of Genome polyprotein [Isoform Lab]
| | First appeared in release: | Release 5.4 (10/14/2010) | | UniProt: | P03305 | | UniGene: | | | SwissProt: | POLG_FMDVO | | TrEMBL: | | | NCBI (GI): | | | Source organism: | Foot-and-mouth disease virus | | Sequence length: | 85 | | Percent disordered: | 71% | | Homologues: | |
| Native sequence |
10 20 30 40 50 60
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GAGQSSPATG SQNQSGNTGS IINNYYMQQY QNSMDTQLGD NAISGGSNEG STDTTSTHTT - 60
NTQNNDWFSK LASSAFSGLF GALLA
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| Functional narrative |
Capsid proteins VP1, VP2, VP3 and VP4 form a closed capsid enclosing the viral positive strand RNA genome. VP4 lies on the inner surface of the protein shell formed by VP1, VP2 and VP3. All the three latter proteins contain a beta-sheet structure called beta-barrel jelly roll. Together they form an icosahedral capsid (T=3) composed of 60 copies of each VP1, VP2, and VP3, with a diameter of approximately 300 Angstroms. VP1 is situated at the 12 fivefold axes, whereas VP2 and VP3 are located at the quasi-sixfold axes. (UniProt) Virion protein 4 is cleavage product 3 of Genome polyprotein [Isoform Lab], comprising aa 202-286 of the polyprotein.
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| Map of ordered and disordered regions |
Note: 'Mouse' over a region to see the start and stop residues. Click on a region to see detailed information.
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| Region 1 | | Type: | Disordered - Extended | | Name: | N-terminal region | | Location: | 1 - 39 | | Length: | 39 | | Region sequence: |
GAGQSSPATGSQNQSGNTGSIINNYYMQQYQNSMDTQLG | | Modification type: | Native
| | PDB: | | | Structural/functional type: | Relationship to function unknown
| | Functional classes: | Unknown
| | Functional subclasses: | Unknown
| Detection methods:
- X-ray crystallography
| References:
- Acharya R, Fry E, Stuart D, Fox G, Rowlands D, Brown F. "The three-dimensional structure of foot-and-mouth disease virus at 2.9 A resolution." Nature. 1989; 337(6209): 709-16. PubMed: 2537470
| Comments:
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| Region 2 | | Type: | Disordered - Extended | | Name: | C-terminal region | | Location: | 65 - 85 | | Length: | 21 | | Region sequence: |
NDWFSKLASSAFSGLFGALLA | | Modification type: | Native
| | PDB: | | | Structural/functional type: | Relationship to function unknown
| | Functional classes: | Unknown
| | Functional subclasses: | Unknown
| Detection methods:
- X-ray crystallography
| References:
- Acharya R, Fry E, Stuart D, Fox G, Rowlands D, Brown F. "The three-dimensional structure of foot-and-mouth disease virus at 2.9 A resolution." Nature. 1989; 337(6209): 709-16. PubMed: 2537470
| Comments:
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| References |
- Acharya R, Fry E, Stuart D, Fox G, Rowlands D, Brown F. "The three-dimensional structure of foot-and-mouth disease virus at 2.9 A resolution." Nature. 1989; 337(6209): 709-16. PubMed: 2537470
- Cheung A, DeLamarter J, Weiss S, Küpper H. "Comparison of the major antigenic determinants of different serotypes of foot-and-mouth disease virus." J Virol. 1983; 48(2): 451-9. PubMed: 6194313
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| Comments |
Previous entry DP00573 has been split into polyprotein (DP00573) and cleavage products (DP00573_C0XX).
Acharya et al (1989) show that VP4 consists of disordered N- and C-terminal regions flanking a 'well-defined helix of three turns, a novel structure for a piconavirus VP4...'.
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