Annotation for this protein is in progress - please check future releases for more complete information


DP00581: Ras-related protein Ral-AFASTA viewXML view

General information
DisProt:DP00581
Name:Ras-related protein Ral-A
Synonym(s):RALA_HUMAN
First appeared in release:Release 4.5 (07/17/2008)
UniProt:P11233
UniGene:Hs.6906
SwissProt: RALA_HUMAN
TrEMBL:  
NCBI (GI): 131834
Source organism:Homo sapiens (Human)
Sequence length:206
Percent disordered:13%
Homologues: 


Native sequence

        10         20         30         40         50         60
         |          |          |          |          |          |
MAANKPKGQN SLALHKVIMV GSGGVGKSAL TLQFMYDEFV EDYEPTKADS YRKKVVLDGE - 60
EVQIDILDTA GQEDYAAIRD NYFRSGEGFL CVFSITEMES FAATADFREQ ILRVKEDENV - 120
PFLLVGNKSD LEDKRQVSVE EAKNRAEQWN VNYVETSAKT RANVDKVFFD LMREIRARKM - 180
EDSKEKNGKK KRKSLAKRIR ERCCIL

Region 1: 1-10 Region 3: 46-49 Region 2: 72-83

Map of ordered and disordered regions







Note: 'Mouse' over a region to see the start and stop residues. Click on a region to see detailed information.


Region 1
Type:Disordered
Name: 
Location:1 - 10
Length:10
Region sequence:

MAANKPKGQN

Modification type: Native
PDB: 1ZC3:A, 1UAD:A, 1ZC4:A, 2A78:A, 2A9K:A, 2BOV:A
Structural/functional type: Function arises via a disorder to order transition
Functional classes: Modification site
Functional subclasses: Protein-protein binding
Detection methods:
 
References:
There are no documents referencing this region.
Comments:
 



Region 2
Type:Disordered
Name:Switch II
Location:72 - 83
Length:12
Region sequence:

QEDYAAIRDNYF

Modification type: Native
PDB: 1ZC3:A, 1ZC4:A, 1UAD:A, 2A78:A, 2A9K:A, 2BOV:A
Structural/functional type: Function arises via a disorder to order transition
Functional classes: Modification site
Functional subclasses: Flexible linkers/spacers
Protein-protein binding
Detection methods:
 
References:
There are no documents referencing this region.
Comments:
 



Region 3
Type:Disordered
Name:Switch I
Location:46 - 49
Length:4
Region sequence:

TKAD

Modification type: Native
PDB: 1UAD:A, 1ZC3:A, 1ZC4:A, 2A78:A, 2A9K:A, 2BOV:A
Structural/functional type: Function arises via a disorder to order transition
Functional classes: Modification site
Functional subclasses: Protein-protein binding
Detection methods:
 
References:
There are no documents referencing this region.
Comments:
 



References

  1. Nicely NI, Kosak J, de Serrano V, Mattos C. "Crystal structures of Ral-GppNHp and Ral-GDP reveal two binding sites that are also present in Ras and Rap." Structure. 2004; 12(11): 2025-36. PubMed: 15530367



Comments


Residue 146 listed as Aspartic Acid(D) as listed by Nicely et. al. paper and not Glutamic Acid(E) as indicated in Swiss-Prot.


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