| General information | | DisProt: | DP00584 | | Name: | Protein starmaker | | Synonym(s): | STM_DANRE
| | First appeared in release: | Release 4.7 (10/08/2008) | | UniProt: | A2VD23 | | UniGene: | Dr.79127 | | SwissProt: | STM_DANRE | | TrEMBL: | | | NCBI (GI): | 166223487 | | Source organism: | Danio rerio (Zebrafish)(Brachydanio rerio) | | Sequence length: | 613 | | Percent disordered: | 100% | | Homologues: | |
| Native sequence |
10 20 30 40 50 60
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MLSRTVFVPL ILAFVGVSIS APVSNNNGTD NDESAADQRH IFTVQFNVGT PAPADGDSVT - 60
TDGKDSAEKN EAPGDSSDTT EKPGTTDGKD SAEQHGVTTD GKDEAEQHGV TTDGQDSAEK - 120
RGEADGAPDK PDTQNGTDDT DSDQETDASH HKTGDSDENK DKPSAEDHTD GNHAGKDSTD - 180
SKESPDTTDK PEGPDSDSAP DGDSASAEKT DSDHSPDEDA NKSSTEADKD DTSDKDSSQT - 240
DEKHDSDASD KDEKHEDKDE KSDEKDSSKD SEDKSQEKSD KSDDGSNSEA DEQKESVESK - 300
DHDSDSQDSD SAEKKEKHDD KDQDSSDSAD SKDSDEDKDK DHSEQKDSED HEHKEKHTKD - 360
KEEHKDSDEG KDDEDKSKSD EHDKDESESK EASKSDESEQ EEKKDDKSDS DNSSRDSHSD - 420
SDSDSHSDSD SDSHSDSHSD SDSDSHSDSD SDSDSDSDSD SDSDSDSNSR DKDEKKDKSS - 480
ESRDEDSSDS DSKSNSESSE TAEEDTNDDK DSSVEKDKTD SSDSASVEAN DSDDEHDDDS - 540
KDATPSSEDH TAEKTDEDSH DVSDDDDDID AHDDEAGVEH GTDEASKPHQ EPDHHDDTTH - 600
GSDDGRKTSM PIS
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| Functional narrative |
Essential for the formation of otoliths in the inner ear of developing larvae and for the perception of gravity and acceleration. May be one of the organic components of the ortholiths.
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| Map of ordered and disordered regions |
Note: 'Mouse' over a region to see the start and stop residues. Click on a region to see detailed information.
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| Region 1 | | Type: | Disordered | | Name: | | | Location: | 1 - 613 | | Length: | 613 | | Region sequence: |
MLSRTVFVPLILAFVGVSISAPVSNNNGTDNDESAADQRHIFTVQFNVGTPAPADGDSVT
TDGKDSAEKNEAPGDSSDTTEKPGTTDGKDSAEQHGVTTDGKDEAEQHGVTTDGQDSAEK
RGEADGAPDKPDTQNGTDDTDSDQETDASHHKTGDSDENKDKPSAEDHTDGNHAGKDSTD
SKESPDTTDKPEGPDSDSAPDGDSASAEKTDSDHSPDEDANKSSTEADKDDTSDKDSSQT
DEKHDSDASDKDEKHEDKDEKSDEKDSSKDSEDKSQEKSDKSDDGSNSEADEQKESVESK
DHDSDSQDSDSAEKKEKHDDKDQDSSDSADSKDSDEDKDKDHSEQKDSEDHEHKEKHTKD
KEEHKDSDEGKDDEDKSKSDEHDKDESESKEASKSDESEQEEKKDDKSDSDNSSRDSHSD
SDSDSHSDSDSDSHSDSHSDSDSDSHSDSDSDSDSDSDSDSDSDSDSNSRDKDEKKDKSS
ESRDEDSSDSDSKSNSESSETAEEDTNDDKDSSVEKDKTDSSDSASVEANDSDDEHDDDS
KDATPSSEDHTAEKTDEDSHDVSDDDDDIDAHDDEAGVEHGTDEASKPHQEPDHHDDTTH
GSDDGRKTSMPIS | | Modification type: | Native
| | PDB: | | | Structural/functional type: | Function arises via a disorder to order transition
| | Functional classes: | Molecular assembly
| | Functional subclasses: | Phosphorylation
Substrate/ligand binding
Protein-protein binding
| Detection methods:
- SDS-PAGE gel, Aberrant mobility on
- Circular dichroism (CD) spectroscopy, far-UV
- Fluorescence polarization/anisotropy
| References:
There are no documents referencing this region. | Comments:
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| References |
- Kapłon TM, Rymarczyk G, Nocula-Ługowska M, Jakób M, Kochman M, Lisowski M, Szewczuk Z, Ozyhar A. "Starmaker exhibits properties of an intrinsically disordered protein." Biomacromolecules. 2008; 9(8): 2118-25. PubMed: 18636772
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