DP00586: Protease A inhibitor 3FASTA viewXML view

General information
DisProt:DP00586
Name:Protease A inhibitor 3
Synonym(s):IPA3_YEAST
Proteinase inhibitor I(A)3
Saccharopepsin inhibitor
Proteinase yscA-inhibitor
First appeared in release:Release 4.9 (01/06/2009)
UniProt:P01094
UniGene: 
SwissProt: IPA3_YEAST
TrEMBL:  
NCBI (GI): 124811
Source organism:Saccharomyces cerevisiae (Baker's yeast)
Sequence length:68
Percent disordered:100%
Homologues: 


Native sequence

        10         20         30         40         50         60
         |          |          |          |          |          |
MNTDQQKVSE IFQSSKEKLQ GDAKVVSDAF KKMASQDKDG KTTDADESEK HNYQEQYNKL - 60
KGAGHKKE



Functional narrative    

Specific and potent inhibitor for yeast aspartic protease A (yscA). The proteinase acts as a folding template stabilizing the helical conformation in the inhibitor, which results in the potent and specific blockage of the proteolytic activity.

Region 1: 1-68

Map of ordered and disordered regions







Note: 'Mouse' over a region to see the start and stop residues. Click on a region to see detailed information.


Region 1
Type:Disordered
Name: 
Location:1 - 68
Length:68
Region sequence:

MNTDQQKVSEIFQSSKEKLQGDAKVVSDAFKKMASQDKDGKTTDADESEKHNYQEQYNKL
KGAGHKKE

Modification type: Native
PDB:  
Structural/functional type: Function arises via a disorder to order transition
Functional classes:  
Functional subclasses: Regulation of proteolysis in vivo
Detection methods:
 
References:
  1. Green TB, Ganesh O, Perry K, Smith L, Phylip LH, Logan TM, Hagen SJ, Dunn BM, Edison AS. "IA3, an aspartic proteinase inhibitor from Saccharomyces cerevisiae, is intrinsically unstructured in solution." Biochemistry. 2004; 43(14): 4071-81. PubMed: 15065849

Comments:
 



References

  1. Phylip LH, Lees WE, Brownsey BG, Bur D, Dunn BM, Winther JR, Gustchina A, Li M, Copeland T, Wlodawer A, Kay J. "The potency and specificity of the interaction between the IA3 inhibitor and its target aspartic proteinase from Saccharomyces cerevisiae." J Biol Chem. 2001; 276(3): 2023-30. PubMed: 11042188


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