General information | DisProt: | DP00587 | Name: | RWD domain-containing protein 1 | Synonym(s): | RWDD1_MOUSE
IH1
DRG family-regulatory protein 2
| First appeared in release: | Release 4.9 (01/06/2009) | UniProt: | Q9CQK7 | UniGene: | Mm.28528 | SwissProt: | RWDD1_MOUSE | TrEMBL: | | NCBI (GI): | 34098700 | Source organism: | Mus musculus (Mouse) | Sequence length: | 243 | Percent disordered: | 100% | Homologues: | |
Native sequence |
10 20 30 40 50 60 | | | | | | MTDYGEEQRN ELEALESIYP DSFTVLSESP PSFTITVTSE AGENDETVQT TLKFTYSEKY - 60 PDETPLYEIF SQENLEDNDV SDILKLLALQ AEENLGMVMI FTLVTAVQEK LNEIVDQIKT - 120 RREEEKKQKE KEAEEAEKKL FHGTPVTIEN FLSWKAKFDA ELLEIKKKRM KEEEQAGKNK - 180 LSGKQLFETD HNLDTSDIQF LEDAGNNVEV DESLFQEMDD LELEDGEDDP DYNPVAPGSD - 240 SSD
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Functional narrative |
Rwdd1 is a thymus aging-related protein which contains an RWD domain at its N-terminus. Rwdd1 is expressed in both thymocytes and thymic epithelial cells and located primarily in the cytoplasm. Rwdd1 expression in thymus was decreased in aged and oxidatively stressed mice. Protects DRG2 from proteolytic degradation.
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Map of ordered and disordered regions |
Note: 'Mouse' over a region to see the start and stop residues. Click on a region to see detailed information.
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Region 1 | Type: | Disordered | Name: | | Location: | 1 - 243 | Length: | 243 | Region sequence: |
MTDYGEEQRNELEALESIYPDSFTVLSESPPSFTITVTSEAGENDETVQTTLKFTYSEKY PDETPLYEIFSQENLEDNDVSDILKLLALQAEENLGMVMIFTLVTAVQEKLNEIVDQIKT RREEEKKQKEKEAEEAEKKLFHGTPVTIENFLSWKAKFDAELLEIKKKRMKEEEQAGKNK LSGKQLFETDHNLDTSDIQFLEDAGNNVEVDESLFQEMDDLELEDGEDDPDYNPVAPGSD SSD | Modification type: | Native
| PDB: | | Structural/functional type: | | Functional classes: | | Functional subclasses: | | Detection methods:
- SDS-PAGE gel, Aberrant mobility on
- Sensitivity to proteolysis (295 K; pH: 8; Proteinas K from 1:100 to 1:6,000.; Tris-HCl 20 mM)
| References:
- Kang N, Chen D, Wang L, Duan L, Liu SR, Tang L, Liu QF, Cui LX, He W. "Rwdd1, a thymus aging related molecule, is a new member of the intrinsically unstructured protein family." Cell Mol Immunol. 2008; 5(5): 333-9. PubMed: 18954556
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