DP00605: Dynein intermediate chain, cytosolic [Isoform 5a (J)]FASTA viewXML view

General information
DisProt:DP00605
Name:Dynein intermediate chain, cytosolic [Isoform 5a (J)]
Synonym(s):DYIN_DROME
DH IC
Cytoplasmic dynein intermediate chain
Protein short wing
First appeared in release:Release 5.1 (05/28/2010)
UniProt:Q24246
UniGene:Dm.20780
SwissProt: DYIN_DROME
TrEMBL:  
NCBI (GI): 32470613
Source organism:Drosophila melanogaster (Fruit Fly)
Sequence length:663
Percent disordered:4%
Homologues: 


Native sequence

        10         20         30         40         50         60
         |          |          |          |          |          |
MDRKAELERK KAKLAALREE KDRRRREKEI KDMEEAAGRI GGGAGIDKDQ RKDLDEMLSS - 60
LGVAPVSEVL SSLSSVNSMT SDNSNTQTPD ASLQATVNGQ SGGKKQPLNL SVYNVQATNI - 120
PPKETLVYTK QTQTTSTGGG NGDVLSCHSS PLSGYMEDWW RPRKAHATDY YDEYNLNPGL - 180
EWEDEFTDDE ESSLQNLGNG FTSKLPPGYL THGLPTVKDV APAITPLEIK KETEVKKEVN - 240
ELSEEQKQMI ILSENFQRFV VRAGRVIERA LSENVDIYTD YIGGGDSEEA NDERSHARLS - 300
LNRVFYDERW SKNRCITSMD WSTHFPELVV GSYHNNEESP NEPDGVVMVW NTKFKKSTPE - 360
DVFHCQSAVM STCFAKFNPN LILGGTYSGQ IVLWDNRVQK RTPIQRTPLS AAAHTHPVYC - 420
LQMVGTQNAH NVISISSDGK LCSWSLDMLS QPQDTLELQQ RQSKAIAITS MAFPANEINS - 480
LVMGSEDGYV YSASRHGLRS GVNEVYERHL GPITGISTHY NQLSPDFGHL FLTSSIDWTI - 540
KLWSLKDTKP LYSFEDNSDY VMDVAWSPVH PALFAAVDGS GRLDLWNLNQ DTEVPTASIV - 600
VAGAPALNRV SWTPSGLHVC IGDEAGKLYV YDVAENLAQP SRDEWSRFNT HLSEIKMNQS - 660
DEV



Functional narrative    

Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. The intermediate chains mediate the help dynein bind to dynactin 150 kDa component.

Region 1: 109-135

Map of ordered and disordered regions







Note: 'Mouse' over a region to see the start and stop residues. Click on a region to see detailed information.


Region 1
Type:Disordered
Name: 
Location:109 - 135
Length:27
Region sequence:

NLSVYNVQATNIPPKETLVYTKQTQTT

Modification type: Fragment
PDB: 3FM7:C
Structural/functional type: Function arises via a disorder to order transition
Functional classes: Molecular assembly
Functional subclasses: Protein-protein binding
Detection methods:
  1. Sensitivity to proteolysis

  2. X-ray crystallography (277.15 K; pH: 6.5; 16% PEG 8K; calcium acetate 200 mM; sodium cacodylate 100 mM)
References:
  1. Hall J, Karplus PA, Barbar E. "Multivalency in the assembly of intrinsically disordered dynein intermediate chain." J Biol Chem. 2009; 284(48): 33115-21. PubMed: 19759397
Comments:
PDB 3FM7 is the wild-type complex of IC/LC Tctex1/LC8. Related PDB 3GLW is a constructed complex of IC/LC8/LC8.

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